Focus
Screening e malattia celiaca
CELIAC DISEASE AND SCREENING
T. Not
Settembre 2005 - pagg. 449 -455
Abstract
From the clinical and the epidemiological point of view, celiac disease may represent an
appropriate disease model to apply a population based screening strategy. In the literature,
the use of human tTG antibodies is described as an efficient screening strategy both in
high risk groups and in family case finding series. However, population based screening
is still a matter of debate, since it is yet not clear which is the most appropriate age when
performing the screening and which motivations to offer to those subjects positive at the
screening but still asymptomatic. It has been suggested to first identify subjects at risk by
neonatal determination of HLA DQ2/DQ8 and to follow them up with periodical sierological
tTG tests in order to identify early celiac patients.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
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6. Mustalahti K, Lohiniemi S, Collin P, et al. Gluten-free diet and quality of life in patients with screen-detected celiac disease. Eff Clin Pract 2002;5:105-13.
2. Hin H, Bird G, Fisher P, Mahy N, Jewell D. Coeliac disease in primary care: case finding study. BMJ 1999;318:164-7.
3. Ventura A, Facchini S, Amantidu S, et al. Searching for celiac disease in pediatric general practice. Clin Pediatr 2001;40:575-7.
4. Young EH, Wareham NJ. Screening for coeliac disease: what evidence is required before population programmes could be considered. Arch Dis Child 2004;89:499- 501.
5. Hoffenberg EJ, MacKenzie T, Barriga KJ, et al. A prospective study of the incidence of childhood celiac disease. J Pediatr 2003; 143:308-14.
6. Mustalahti K, Lohiniemi S, Collin P, et al. Gluten-free diet and quality of life in patients with screen-detected celiac disease. Eff Clin Pract 2002;5:105-13.