Osteomielite multifocale ricorrente e biopsia ossea: la difficoltà di sentirsi sicuri nell’'inusuale

We report the case of an 11 years old child with recurrent joint pain associated with fever and multifocal bone involvement, which developed in the course of a couple of years. X-rays showed a significant periosteal reaction, allowing the diagnosis of recurrent multifocal osteomyelitis (CRMO). Two bone biopsies were performed to rule out a malignanc. The second biopsy was performed at a time when the clinical diagnosis was reasonably sure. The diagnostic challenges and therapeutic issues of this condition are discussed.