Eteroplasia ossificante progressiva: una nuova mutazione del gene GNAS1 e rassegna della letteratura

Progressive osseous heteroplasia (PHO) is a recently described genetic disorder of mesenchymal differentiation characterized by dermal ossification during infancy and by progressive heterotopic ossification of cutaneous, subcutaneous and deep connective tissues during childhood. We report a case of progressive osseous heteroplasia resulting from a de novo mutation in the GNAS1 gene with only the mutations of the GNAS1 gene reported so far in progressive osseous heteroplasia. This new mutation helps extend the genotype-phenotype correlation further.