Focus
I depositi intestinali degli anticorpi anti-transglutaminasi
Intestinal deposits of anti-transglutaminase antibodies
L. De Leo, I. Korponai-Szabo, M. Mäki, G. Di Leo, S. Martelossi, V. Villanacci, T. Not, A. Ventura
Marzo 2016 - pagg. 159 -176
Abstract
The serum anti-transglutaminase antibodies are the immunological markers for coeliac
disease diagnosis. These autoantibodies are synthesized by B-lymphocytes at the intestinal
level and their presence in the form of intestinal deposits is a constant feature in the
different clinical entities in which coeliac disease is classified: classical, silent, and potential.
These intestinal autoantibodies are the first gluten dependent inflammatory markers
and they appear before both the intestinal damage and the serum anti-transglutaminase
antibodies. The anti-transglutaminase deposits should be looked for to confirm or
exclude the diagnosis of coeliac disease when the clinical and immunological features
are incomplete or in asymptomatic at risk patients.
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Bibliografia
1. Green PH, Cellier C. Celiac diease. N Engl
J Med 2007;357(17):1731-43.
2. Husby S, Koletzko S, Korponay-Szabó IR,
et al.; ESPGHAN Working Group on Coeliac
Disease Diagnosis; ESPGHAN Gastroenterology
Committee; European Society for
Pediatric Gastroenterology, Hepatology, and
Nutrition. European Society for Pediatric
Gastroenterology, Hepatology, and Nutrition
guidelines for the diagnosis of coeliac disease.
J Pediatr Gastroenterol Nutr 2012;54
(1):136-60.
3. Marzari R, Sblattero D, Florian F, et al.
Molecular dissection of the tissue transglutaminase
antibody response in celiac disease. J
Immunol 2001;166(6):4170-6.
4. Salmi TT, Collin P, Järvinen O, et al. Immunoglobulin
A autoantibodies against transglutaminase
2 in the small intestinal mucosa
predict forthcoming coeliac disease. Aliment
Pharmacol Ther 2006;24(3):541-52.
5. Tosco A, Salavati V, Auricchio R, et al. Natural
history of potwential celiac disease in
children. Clin Gastroenterol Hepatol 2011;
9(4):320-5;quiz e36.
6. Salmi TT, Hervonen K, Laurila K, et al.
Small bowell transglutaminase 2-specific IgA
deposits in dermatitis herpetiformis. Acta
Derm Venereol 2014;94(4):393-7.
7. Hadjivassiliou M, Mäki M, Sanders DS,
Williamson CA, et al. Autoantibody targeting
of brain and intestinal transglutaminase in
gluten ataxia. Neurology 2006;66(3):373-7.
8. Quaglia S, De Leo L, Ziberna F, et al. Intestinal-
mucosa anti-transglutaminase antibody
assays to test for genetic gluten intolerance.
Cell Mol Immunol 2014;11(6):617-20.
9. Maglio M, Florian F, Vecchiet M, et al.
Majority of children with type 1 diabetes produce
and deposit anti-tissue transglutaminase
antibodies in the small intestine. Diabetes
2009;58(7):1578-84.
10. Del Leo, Ziberna F, Vatta S, et al. Intestinal
anti-transglutaminase antibodies to discover
genetic gluten intolerance. JPGN 2014;
58:60 (47th ESPGHAN meeting, Jerusalem
2014).
11. Not T, Ziberna F, Vatta S, et al. Cryptic
genetic gluten intolernace revealed by intestinal
antitransglutaminase antibodies and
response to gluten free diet. Gut 2011;60:
1487.
Corrispondenza: deleo.luigina@libero.it