Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
Login Abbonamenti Pubblicazioni Carrello Registrazione Perché registrarsi? Contatti

Neonatologia

Osservazione nel neonato a rischio di sepsi precoce

Observation on the newborn at risk of early-onset sepsis: the approach of the Emilia-Romagna Region (Italy)

A. Berardi, C. Spada, M. Ciccia, M Capretti, G. Brusa, F. Sandri, E. Balestri, L. Rocca, L. Gambini, M. Azzalli, V. Rizzo, G. Piccinini, E. Vaccina, L. Lucaccioni

Giugno 2019 - pagg. 370 -376

Abstract
The approach to the newborn at risk of early-onset sepsis is a challenge. In the past the approach was mainly based on laboratory tests, which were poorly predictive and might cause repeated blood samples and unnecessary antibiotic therapies, with possible long-term side effects. The medicalisation of asymptomatic newborns also interferes with breastfeeding. Recent experiences carried out in the Friuli Venezia Giulia and Emilia-Romagna Regions (Italy) have suggested that a less invasive approach is useful. This approach is mainly based on careful and repeated clinical observations of asymptomatic full-term or late preterm infants at standard intervals, regardless of risk factors. Moreover, it is useful for a timely diagnosis, does not separate mothers from their neonates and consequently does not interfere with the development of the nascent intestinal microbiota and breastfeeding.
Contenuto riservato

Per leggere l'articolo completo è necessario effettuare il login.

Non sei ancora registrato? Registrati

Bibliografia

1. Schrag SJ, Farley MM, Petit S, et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics 2016;138(6): e20162013. 2. Berardi A, Baroni L, Bacchi Reggiani ML, et al.; GBS Prevention Working Group Emilia- Romagna. The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population- based study. J Matern Fetal Neonatal Med 2016;29(19):3126-31. 3. Centers for Disease Control and Prevention. Active Bacterial Core surveillance (ABCs) Report Emerging Infections Program Network Group B Streptococcus. 2014. 4. Berardi A, Lugli L, Rossi C, et al; GBS Prevention Working Group, Emilia-Romagna. Impact of perinatal practices for early-onset group B Streptococcal disease prevention. Pediatr Infect Dis J 2013;32:e265-71. 5. Puopolo KM, Benitz WE, Zaoutis TE; AAP Committee on Fetus and Newborn; AAP Committee on Infectious Diseases. Management of neonates born at ≤ 34 6/7 weeks’ gestation with suspected or proven early-onset bacterial sepsis. Pediatrics 2018;142:e2018-96. 6. Puopolo KM, Benitz WE, Zaoutis TE; AAP Committee on Fetus and Newborn; AAP Committee on Infectious Diseases. Management of neonates born at ≥ 35 0/7 weeks’ gestation with suspected or proven early-onset bacterial sepsis. Pediatrics 2018;142:e2018-94. 7. Benitz WE. Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clin Perinatol 2010;37(2):421-38. 8. Benitz WE, Wynn JL, Polin RA. Reappraisal of guidelines for management of neonates with suspected early-onset sepsis. J Pediatr 2015;166(4):1070-4. 9. Verani JR, McGee L, Schrag SJ. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centres for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease-revised guidelines from CDC, 2010. MMWR Recomm Rep 2010;59(RR-10):1-36. 10. Hooven TA, Randis TM, Polin RA. What’s the harm? Risks and benefits of evolving rule- out sepsis practices. J Perinatol 2018;38 (6):614-22. 11. van Herk W, Stocker M, van Rossum AM. Recognising early onset neonatal sepsis: an essential step in appropriate antimicrobial use. J Infect 2016;72 Suppl:S77-82. 12. Ficara M, Pietrella E, Spada C, et al. Changes of intestinal microbiota in early life. J Matern Fetal Neonatal Med 2018, Sep 10:1- 8 [Epub ahead of print]. 13. Corvaglia L, Tonti G, Martini S, et al. Influence of intrapartum antibiotic prophylaxis for group B Streptococcus on gut microbiota in the first month of life. J Pediatr Gastroenterol Nutr 2016;62(2):304-8. 14. Randis TM, Polin RA, Saade G. Chorioamnionitis: time for a new approach. Curr Opin Pediatr 2017;29(2):159-64. 15. Cantoni L, Ronfani L, Da Riol R, Demarini S; Perinatal Study Group of the Region Friuli Venezia Giulia. Physical examination instead of laboratory tests for most infants born to mothers colonized with group B streptococcus: support for the Centers for Disease Control and Prevention’s 2010 recommendations. J Pediatr 2013;163(2):568-73. 16. Berardi A, Buffagni AM, Rossi C, et al. Serial physical examinations, a simple and reliable tool for managing neonates at risk for early-onset sepsis. World J Clin Pediatr 2016;5(4):358-64. 17. Berardi A, Fornaciari S, Rossi C, et al. Safety of physical examination alone for managing well-appearing neonates ≥ 35 weeks’ gestation at risk for early-onset sepsis. J Matern Fetal Neonatal Med 2015;28(10):1123-7. 18. Illuzzi JL, Bracken MB. Duration of intrapartum prophylaxis for neonatal group B streptococcal disease: a systematic review. Obstet Gynecol 2006;108(5):1254-65. 19. Bloom SL, Cox SM, Bawdon RE, Gilstrap LC. Ampicillin for neonatal group B streptococcal prophylaxis: how rapidly can bactericidal concentrations be achieved? Am J Obstet Gynecol 1996;175(4 Pt 1):974-6. 20. Barber EL, Zhao G, Buhimschi IA, Illuzzi JL. Duration of intrapartum prophylaxis and concentration of penicillin G in fetal serum at delivery. Obstet Gynecol 2008;112(2 Pt 1):265-70. 21. Berardi A, Rossi C, Biasini A, et al. Efficacy of intrapartum chemoprophylaxis less than 4 hours duration. J Matern Fetal Neonatal Med 2011;24(4):619-25. 22. Berardi A, Pietrangiolillo Z, Bacchi Reggiani ML, et al. Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates. Arch Dis Child Fetal Neonatal Ed 2018; 103(2):F152-6. 23. Fairlie T, Zell ER, Schrag S. Effectiveness of intrapartum antibiotic prophylaxis for prevention of early-onset group B streptococcal disease. Obstet Gynecol 2013;121(3):570-7. 24. Committee on Obstetric Practice. Committee Opinion No. 712: Intrapartum Management of Intraamniotic Infection. Obstet Gynecol 2017;130(2):e95-e101. 25. Kuzniewicz MW, Puopolo KM, Fischer A, et al. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr 2017;171(4):365-71. 26. Berardi A, Guidotti I, Vellani G, et al. La gestione del nato a rischio di infezione precoce. Medico e Bambino 2013;32(8):507-13. 27. Berardi A, Lugli L, Rossi C, et al. Neonatal bacterial meningitis. Minerva Pediatr 2010;62(3 Suppl 1):51-4. 28. Berardi A, Cattelani C, Creti R, et al. Group B streptococcal infections in the newborn infant and the potential value of maternal vaccination. Expert Rev Anti Infect Ther 2015;13(11):1387-99. 29. Berardi A, Ficara M, Pietrella E. Stewardship antimicrobica nel neonato e nel piccolo lattante. Perché e come praticarla. Medico e Bambino 2017;36(8):493-501.

Corrispondenza: aberardi@unimore.it