Problemi correnti
Profilassi antibiotica nei bambini con RVU
ANTIBIOTIC PROPHYLAXIS IN CHILDREN WITH VESICOURETHERAL REFLUX
MARCO PENNESI
Clinica Pediatrica, IRCCS “Burlo Garofolo”, Trieste
Dicembre 2000 - pagg. 638 -641
Abstract
Vesicouretheral reflux (VUR) is the most frequent congenital anomaly of the urinary tract
and reflux nephropathy is the most common cause of chronic renal insufficiency in children
and young people. There is consensus on conservative treatment (antibiotic prophylaxis) of
VUR, but we still lack conclusive evidence of its efficacy in preventing reflux nephropathy.
Moreover, recent studies stress the importance of VUR-associated renal dysplasia as the
main cause of chronic renal insufficiency. This should prompt a thorough re-evaluation of
this topic.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
1. Piepsz A, Tamminen-Mobius T, Reiners C.
Five-year study of medical or surgical treatment
in children with severe vesico-uretheral
reflux dimercaptosuccinic acid findings.
International Reflux Study Group in Europe.
Eur J Pediatr 1998;157:753-8.
2. Smellie JM, Tamminen-Mobius T, Olbing H, et al. Five-year study of medical or surgical treatment in children with severe reflux: radiological renal findings. The International Reflux Study in Children. Ped Nephrol 1992; 6:223-30.
3. Jodal U, Hansson S, Hjalmas K. Medical or surgical management in children with vesico- uretheric reflux? Acta Paediatr 1999; 88:53-61.
4. Birmingham Reflux Study Group. Prospective trial of operative versus non-operative treatment of severe vesicouretheric reflux in children: five years’ observation. Br Med J 1987; 295:237-41.
5. Hodson J, Kincaid-Smith P. Reflux Nephropathy. Milano: Masson ed, 979:7.
6. Ransley PG, Risdon RA. Reflux nephropathy: effects of antimicrobial therapy on the evolution of the early pyelonephritic scar. Kidney Int 1981;20:733-42.
7. Friedland GW. Long-term effects of urinary tract infections. The need for a controlled trial. Radiology 1977;134:263-4.
8. Aperia A. Broberger O, Ericsson NO. Effect of vesicouretheral reflux on renal function in children with recurrent urinary tract infections. Kidney Int 1976;9:418-23.
9. Wolfish N. Prevalence of hypertension in children with primary vesicouretheral reflux. J Pediatr 1993;123:559-63.
10. Sreenarasimhaiah S, Hellerstein S. Urinary tract infections per se do not cause endstage kidney disease. Pediatr Nephrol 1998; 12:210-2.
11. Report on management of renal failure in children in Europe, XXIII, 1992. Nephrol Dial Transpl 1994;S1:26-40.
12. Craig JC, Irwing LM, Knight JF, et al. Does treatment of vesicouretheric reflux in childhood prevent End-Stage Renal Disease attributable to reflux nephropathy? Pediatrics 2000;106:1236-41.
13. Verrier Jones K. Vesico-uretheric reflux: a perspective on management. Pediatr Nephrol 1996;10:795-7.
14. Assael BM, Marra G. Congenital reflux nephropaty: a follow-up of 108 cases diagnosed perinatally. British J Urol 1998;82:252-7.
15. Ransley PG, Smellie J, Normand I. The characteristics of primary vesico-uretheric reflux in male and in female infants with pre-natal hydronephrosis. Br J Urol 1997;80:319-7.
16. Wennerstrom M, Hansson S, Jodal U. Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr 2000;136:30-4.
17. Georgaki P. Long term immagining data in children with vesicouretheral reflux without antibiotic prophylaxis. Atti del Congresso Int Ped Nephrol Ass 1998:137.
18. Stark H. The management of urinary tract infections. Pediatr Nephrol 1999; 13:365.
19. Bollgren I. Antibacterial prophylaxis in children with urinary tract infections. Acta Paediatr 1999;88:48-52.
20. Garin EH. Primary vesicouretheral reflux: review of current concepts. Pediatr Nephrol 1998;12:249-56.
21. Verrier Jones K. Vesico-uretheric reflux: a medical perspective on management. Pediatr Nephrol 1996;10:795-7.
22. Dick PT, Feldman W. Routine diagnostic imagining for childhood urinary tract infections: A systematic overview. J Pediatr 1996; 128:15-22.
23. Greenfield SP. Vesicouretheral reflux: pratical aspect of evaluation and management. Pediatr Nephrol 1996;10:789-94.
2. Smellie JM, Tamminen-Mobius T, Olbing H, et al. Five-year study of medical or surgical treatment in children with severe reflux: radiological renal findings. The International Reflux Study in Children. Ped Nephrol 1992; 6:223-30.
3. Jodal U, Hansson S, Hjalmas K. Medical or surgical management in children with vesico- uretheric reflux? Acta Paediatr 1999; 88:53-61.
4. Birmingham Reflux Study Group. Prospective trial of operative versus non-operative treatment of severe vesicouretheric reflux in children: five years’ observation. Br Med J 1987; 295:237-41.
5. Hodson J, Kincaid-Smith P. Reflux Nephropathy. Milano: Masson ed, 979:7.
6. Ransley PG, Risdon RA. Reflux nephropathy: effects of antimicrobial therapy on the evolution of the early pyelonephritic scar. Kidney Int 1981;20:733-42.
7. Friedland GW. Long-term effects of urinary tract infections. The need for a controlled trial. Radiology 1977;134:263-4.
8. Aperia A. Broberger O, Ericsson NO. Effect of vesicouretheral reflux on renal function in children with recurrent urinary tract infections. Kidney Int 1976;9:418-23.
9. Wolfish N. Prevalence of hypertension in children with primary vesicouretheral reflux. J Pediatr 1993;123:559-63.
10. Sreenarasimhaiah S, Hellerstein S. Urinary tract infections per se do not cause endstage kidney disease. Pediatr Nephrol 1998; 12:210-2.
11. Report on management of renal failure in children in Europe, XXIII, 1992. Nephrol Dial Transpl 1994;S1:26-40.
12. Craig JC, Irwing LM, Knight JF, et al. Does treatment of vesicouretheric reflux in childhood prevent End-Stage Renal Disease attributable to reflux nephropathy? Pediatrics 2000;106:1236-41.
13. Verrier Jones K. Vesico-uretheric reflux: a perspective on management. Pediatr Nephrol 1996;10:795-7.
14. Assael BM, Marra G. Congenital reflux nephropaty: a follow-up of 108 cases diagnosed perinatally. British J Urol 1998;82:252-7.
15. Ransley PG, Smellie J, Normand I. The characteristics of primary vesico-uretheric reflux in male and in female infants with pre-natal hydronephrosis. Br J Urol 1997;80:319-7.
16. Wennerstrom M, Hansson S, Jodal U. Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr 2000;136:30-4.
17. Georgaki P. Long term immagining data in children with vesicouretheral reflux without antibiotic prophylaxis. Atti del Congresso Int Ped Nephrol Ass 1998:137.
18. Stark H. The management of urinary tract infections. Pediatr Nephrol 1999; 13:365.
19. Bollgren I. Antibacterial prophylaxis in children with urinary tract infections. Acta Paediatr 1999;88:48-52.
20. Garin EH. Primary vesicouretheral reflux: review of current concepts. Pediatr Nephrol 1998;12:249-56.
21. Verrier Jones K. Vesico-uretheric reflux: a medical perspective on management. Pediatr Nephrol 1996;10:795-7.
22. Dick PT, Feldman W. Routine diagnostic imagining for childhood urinary tract infections: A systematic overview. J Pediatr 1996; 128:15-22.
23. Greenfield SP. Vesicouretheral reflux: pratical aspect of evaluation and management. Pediatr Nephrol 1996;10:789-94.