Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Lo screening della microangiopatia diabetica

SCREENING OF DIABETIC ANGIOPATHY: A PAEDIATRIC PROBLEM

FRANCESCO CHIARELLI, DANIELA TROTTA

Clinica Pediatrica, Università di Chieti

Gennaio 2002 - pagg. 37 -40

Abstract
Retinopathy and glomerulopathy are among the most severe complications of type 1 diabetes. Retinopathy is relatively common in early onset diabetes. The best screening method for diabetic retinopathy is stereoscopic color fundus photography. Microalbuminuria, as defined by urinary escretion of albumin in 2 out of 3 24-hours urine samples, is the best screening method for the screening of early stages of diabetic nephropathy. It should be accompanied by periodical blood pressure control. If the onset of diabetes is prepuberal, both screening should be started not later than 5 years from the onset, and anyway when the patient is 11 years old, then it should be repeated every year. If the onset of diabetes is after puberty has started, the screening is recommended 2 years after onset, then every year. Abnormal screening findings should always prompt a revision of the case-management strategy.
Bibliografia
1. Clarke BF. Screening for complications in adolescence and beyond. In Kelnar C (ed). Diabetes mellitus in children and adolescence. London: Chapman & Hall, 1994, pp 539- 51.
2. Danne T, Kordonouri O, Hövener G, Weber B. Diabetic angiopathy in children. Diabetic Med 1997;14:1012-25.
3. Sochett E, Daneman D. Early diabetes-related complications in children and adolescents with type 1 diabetes. Endocrinol Metab Clin North Am 1999;28:865-882.
4. Early Treatment Diabetic Retinopathy Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographsan extension of the modified Airlie-House classification. ETDRS Report 10. Ophtalmology 1991;98:786-806.
5. Danne T, Kordonouri O, Casani A, Chiarelli F. Diabetic retinopathy in children and adolescents. Diab Nutr Metab 1999; 12: 136-144.
6. ISPAD Consensus Guidelines 2000. Vascular complications, 2000, pp 95-101.
7. Casani A, Bangstad H-J, Chiarelli F. Detection and management of diabetic glomerulopathy in children and adolescents with insulin- dependent diabetes mellitus: need for improved knowledge and better care. J Pediatr Endocrinol Metab 2000;13:467-74.
8. Chiarelli F, Casani A, Tumini S, Kordonouri O, Danne T. Diabetic nephropathy in children and adolescents. Diab Nutr Metab 1999; 144-152.
9. Couper JJ, Clarke CF, Byrne GC, et al. Progression of borderline increase in albuminuria in adolescents with insulin-dependent diabetes. Diabetic Med 1997;14:766-71.
10. Chiarelli F, Casani A, Verrotti A, Morgese G, Pinelli L. Diabetic nephropathy in children and adolescents: a critical review with particolar reference to angiotensin-converting enzyme inhibitors. Acta Paediatr Suppl 1998;425: 42-5.
11. Ritz E, Rychlik I, Schomig M, Wagner J. Blood pressure in diabetic nephropathy-current controversies. J Intern Med 2001;249: 215-23.
12. Caramori ML, Fioretto P, Mauer M. The need for early predictors of diabetic nephropathy risk. Diabetes 2000;49:1399-408.