Aggiornamento monografico
La borreliosi di Lyme in età pediatrica: individuata un’area endemica in Sicilia
LYME DISEASE IN CHILDHOOD: DATA FROM AN ENDEMIC AREA IN SICILY
D.C. SALPIETRO, S. BRIUGLIA, M.V. MERLINO, F. FULIA, K. MUNAF̉, G. MUSCOLINO, G. BISIGNANO*
Dipartimento di Scienze Pediatriche, Cattedra di Terapia Pediatrica;
Dipartimento Farmacobiologico, Cattedra di Microbiologia, Università di Messina
Ottobre 2002 - pagg. 495 -501
Abstract
In Italy, Lyme disease is endemic in a few geographical areas (the Carsic highlands in Venezia-
Giulia, inner Liguria). The Authors identified a new endemic area in the Messina province
(Nebrodi mountains). From 1989 to 2001, 91 cases of Lyme disease have been described,
74 of them in the paediatric age. In 31 cases the clinical features have included the
skin only, in 15 the skin and the joints, in 38 the joints only; in 7 cases neurological signs were
the only manifestation. Antibiotics are indicated by the oral or parenteral route, depending
on the clinical features. Immunisation has been recently proposed but it is not recommended
in the paediatric age.
Parole chiave
Classificazione MeSH
Bibliografia
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5. Dennis DT, Wormser GP, Dattwyler RJ, et al. Practice guidelines for the Treatment of Lyme Disease. Clinical Infectious Disease 2000; 31:1-14.
6. Gerber MA, Zalneraitis EL. Childhood neurologic disorders and Lyme disease during pregnancy. Pediatr Neurol 1994;11(1):41-3.
7. Masuzawa T, Takada N, Kudeken M, et al. Borrelia sinica sp. Nov., a Lyme disease-related Borrelia species isolated in China. Int J Syst Evol Microbiol 2001;51(pt5):1817-24.
8. Salpietro DC, Bisignano G, Stelitano A, et al. Sieroprevalenza di anticorpi anti-Borrelia burgdorferi in madri e neonati provenienti da un’area a rischio. Rivista Italiana di Pediatria 1996;22/S-2:145.
9. Salpietro DC, Calcagno G, Cocuzza D, et al. Pediatric neuroborreliosis in Sicily (Italy): clinical and therapeutical considerations on three cases reports. European Journal of clinical Microbiology & Infectious disease. In press.
10. Salpietro DC, Minciullo PL, Merlino MV, et al. A case of Parry-Romberg syndrome with antibodies to Borrelia in an endemic area for Lyme disease. American Journal of Medical Genetics. In press.
11. Silver HM. Lyme disease during pregnancy. Inf Dis Clin N Am 1997;1:93-7.
12. Mc Donald AB. Gestational Lyme borreliosis. Implications for the fetus. Rheum Dis Clin N Am 1989;15(4):657-77.
13. Cimmino MA, et al. L’artrite di Lyme, RMP
492. Reumatologia 1994;53:7-29.
14. Wang P, et al. Contribution of HLA alleles in the regulation of antibody production in Lyme disease. Front Biosci 2001;16:B10-6.
15. Harjacek M. Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis. J Rheum 2000;27(2):497-503.
16. Brown JP, et al. Dual role of interleukin-10 in Murine Lyme disease: regulation of arthritis severity and host defense. Infect Immun 1999; 67(10):5142-50.
17. Brown CR, et al. Experimental Lyme arthritis in the absence of interleukin-4 or gamma interferon. Infect Immun 1999;67(7):3329-33.
18. Infectious Society of America. Clinical Infectious Diseases 2000;31:1-14.
2. Barberi I, Bisignano G, Di Bella MR, et al. Trattamento con azitromicina in un caso di artrite di Lyme. Convegno Nazionale di Antibioticoterapia in età pediatrica. Milano, 1993.
3. Caruso G, Ciarrochi S, Ciceroni L, et al. Isolation and characterization of Borrelia burgdorferi Sensu Lato Strains in an Area of Italy where Lyme Borreliosis Is Endemic. Journal of Clinical Microbiology 2001;39:2254-60.
4. Ciarrocchi S, Ciceroni L. Lyme disease in Italy, 1983-1996. Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Roma. Microbiologica 1998;21:407-18.
5. Dennis DT, Wormser GP, Dattwyler RJ, et al. Practice guidelines for the Treatment of Lyme Disease. Clinical Infectious Disease 2000; 31:1-14.
6. Gerber MA, Zalneraitis EL. Childhood neurologic disorders and Lyme disease during pregnancy. Pediatr Neurol 1994;11(1):41-3.
7. Masuzawa T, Takada N, Kudeken M, et al. Borrelia sinica sp. Nov., a Lyme disease-related Borrelia species isolated in China. Int J Syst Evol Microbiol 2001;51(pt5):1817-24.
8. Salpietro DC, Bisignano G, Stelitano A, et al. Sieroprevalenza di anticorpi anti-Borrelia burgdorferi in madri e neonati provenienti da un’area a rischio. Rivista Italiana di Pediatria 1996;22/S-2:145.
9. Salpietro DC, Calcagno G, Cocuzza D, et al. Pediatric neuroborreliosis in Sicily (Italy): clinical and therapeutical considerations on three cases reports. European Journal of clinical Microbiology & Infectious disease. In press.
10. Salpietro DC, Minciullo PL, Merlino MV, et al. A case of Parry-Romberg syndrome with antibodies to Borrelia in an endemic area for Lyme disease. American Journal of Medical Genetics. In press.
11. Silver HM. Lyme disease during pregnancy. Inf Dis Clin N Am 1997;1:93-7.
12. Mc Donald AB. Gestational Lyme borreliosis. Implications for the fetus. Rheum Dis Clin N Am 1989;15(4):657-77.
13. Cimmino MA, et al. L’artrite di Lyme, RMP
492. Reumatologia 1994;53:7-29.
14. Wang P, et al. Contribution of HLA alleles in the regulation of antibody production in Lyme disease. Front Biosci 2001;16:B10-6.
15. Harjacek M. Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis. J Rheum 2000;27(2):497-503.
16. Brown JP, et al. Dual role of interleukin-10 in Murine Lyme disease: regulation of arthritis severity and host defense. Infect Immun 1999; 67(10):5142-50.
17. Brown CR, et al. Experimental Lyme arthritis in the absence of interleukin-4 or gamma interferon. Infect Immun 1999;67(7):3329-33.
18. Infectious Society of America. Clinical Infectious Diseases 2000;31:1-14.