Problemi correnti
Il deficit di vitamina K nel neonato
VITAMIN K DEFICIENCY IN NEWBORNS
SERGIO DE MARINI
Divisione di Neonatologia e TIN, IRCCS “Burlo Garofolo”, Trieste
Novembre 2003 - pagg. 586 -587
Abstract
Classical haemorragic disease of the newborn (first week of life) can be effectively prevented
by oral or parenteral vitamin K supplementation. Late haemorragic disease of the newborn
(2-12 weeks of life) is a rare but severe disease, presenting as intracranial haemorrhage in
50-80% of cases. It occurs in exclusively breastfed infants with inadequate vitamin K prophylaxis,
and in infants with malabsorption syndromes. Late haemorragic disease of the newborn
can be effectively prevented by a single intramuscular dose at birth. An alternative regimen
may be a daily oral vitamin K supplementation for 13 weeks. The American Academy of Pediatrics
recommends a single intramuscular dose of vitamin K at birth.
Suggerite dall'AI
Classificazione MeSH
Bibliografia
1. Golding J, et al. Childhood cancer, intramuscular
vitamin K, and petidine given during labour.
BMJ 1992;305:341-6.
2. Klebanoff MA, Read JS, Mills JL, et al. The risk of childhood cancer after neonatal exposure to vitamin K. N Engl J Med 1993; 329:905-8.
3. Ross JA, Davies SM. Vitamin K prophylaxis and childhood cancer. Med Pediatr Oncol 2000;34:434-7.
4. Loughnan P, Chant KM, Elliott E, et al. The frequency of late onset haemorrhagic disease in Australia with different method of prophylaxis, 1993-1997. An update. J Paediatr Child Health 1999;35:A8.
5. Cornelissen M, Von Kries R, Loughnan P, Schubiger G. Prevention of vitamin K deficiency bleeding: efficacy of different multiple oral dose schedules of vitamin K. Eur J Pediatr 1997;156:126-30.
6. Wariyar U, Hilton S, Pagan J, et al. Six years’ experience of prophylactic oral vitamin K. Arch Dis Child Fetal Neonatal Ed 2000;82:F64-F68.
7. Von Kries R, Hachmeister A, Goebel U. Oral mixed micellar vitamin K for prevention of late vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 2003;88:F109.
8. Pereira SP, Shearer MJ, Williams R, Mieli- Vergani G. Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 2003;88:F113.
9. Von Kries R. Oral versus intramuscular phytomenadione: safety and efficacy compared. Drug Saf 1999;21:1-6.
10. Brousson MA, Klein MC. Controversies surrounding the administration of vitamin K to newborns: a review. CMAJ 1996;154:307-15.
11. American Academy of Pediatrics. Controversies concerning vitamin K and the Newborn. Pediatrics 2003;112:191-2.
2. Klebanoff MA, Read JS, Mills JL, et al. The risk of childhood cancer after neonatal exposure to vitamin K. N Engl J Med 1993; 329:905-8.
3. Ross JA, Davies SM. Vitamin K prophylaxis and childhood cancer. Med Pediatr Oncol 2000;34:434-7.
4. Loughnan P, Chant KM, Elliott E, et al. The frequency of late onset haemorrhagic disease in Australia with different method of prophylaxis, 1993-1997. An update. J Paediatr Child Health 1999;35:A8.
5. Cornelissen M, Von Kries R, Loughnan P, Schubiger G. Prevention of vitamin K deficiency bleeding: efficacy of different multiple oral dose schedules of vitamin K. Eur J Pediatr 1997;156:126-30.
6. Wariyar U, Hilton S, Pagan J, et al. Six years’ experience of prophylactic oral vitamin K. Arch Dis Child Fetal Neonatal Ed 2000;82:F64-F68.
7. Von Kries R, Hachmeister A, Goebel U. Oral mixed micellar vitamin K for prevention of late vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 2003;88:F109.
8. Pereira SP, Shearer MJ, Williams R, Mieli- Vergani G. Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 2003;88:F113.
9. Von Kries R. Oral versus intramuscular phytomenadione: safety and efficacy compared. Drug Saf 1999;21:1-6.
10. Brousson MA, Klein MC. Controversies surrounding the administration of vitamin K to newborns: a review. CMAJ 1996;154:307-15.
11. American Academy of Pediatrics. Controversies concerning vitamin K and the Newborn. Pediatrics 2003;112:191-2.