Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Farmacoriflessioni

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Farmaci e gravidanza

DRUGS AND PREGNANCY

RENATA BORTOLUS1,2, PIERPAOLO MASTROIACOVO2

1ULSS 4 “Alto Vicentino”, Vicenza
2International Centre on Birth Defects, Roma

Dicembre 2005 - pagg. 659 -665

Abstract
Drug use among women of childbearing age and during early pregnancy is common. Pregnant women may require drugs because of an ongoing medical condition, may take them prior to the confirmation of pregnancy, or may use over-the-counter drugs. Approximately 30 human teratogenic drugs have been identified until now. Estimations indicate that less than 1% of birth defects are attributable to drugs, which, however, represents an avoidable part of congenital malformations. When treating a pregnant woman is therefore necessary for doctors to find and give reliable information not only on risks but also on safety of drugs in pregnancy. The role of the pediatrician is discussed.
Parole chiave
Drugs Farmaci Gravidanza Malformations malformazioni Pregnancy Teratogenicità Teratogenicity
Suggerite dall'AI
Birth defects Malformazioni congenite Talidomide Thalidomide
Classificazione MeSH
Congenital, Hereditary, and Neonatal Diseases and Abnormalities Congenital Abnormalities Abnormalities, Drug-Induced (11)
Chemically-Induced Disorders Drug-Related Side Effects and Adverse Reactions (116)
Reproductive and Urinary Physiological Phenomena Reproductive Physiological Phenomena Reproduction Pregnancy (44)
Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Prenatal Injuries Prenatal Exposure Delayed Effects (34)
Pharmaceutical Preparations Prescription Drugs
Organic Chemicals Hydrocarbons Hydrocarbons, Cyclic Hydrocarbons, Alicyclic Cycloparaffins Cyclohexanes
Chemical Actions and Uses Toxic Actions Noxae Teratogens (9)
Organic Chemicals Carboxylic Acids Acids, Carbocyclic Phthalic Acids Phthalimides Thalidomide (16)
Leggi anche
EL Appunti di Terapia
Le benzodiazepine in gravidanza danneggiano il feto ?
G. Bartolozzi · 1999
Teratogens, Abnormalities, Drug-Induced, Prenatal Exposure Delayed Effects
EL Il punto su
Position statement sull’uso di farmaci da parte della donna che allatta al seno
Ministero della Salute · 2018
Prescription Drugs/Pharmaceutical Preparations, Drug-Related Side Effects and Adverse Reactions
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Bibliografia
1. CINECA. Consorzio Interuniversitario. Progetto ARNO. Donne e Farmaci. Rapporto 2003, Volume VII. Bologna: CENTAURO Editore.
2. Einarson A, Maltepe C, Navioz Y, Kennedy D, Tan MP, Koren G. The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study. Br J Obstet Gynaecol 2004;111:940-3.
3. AAVV. Farmaci e gravidanza. La valutazione del rischio teratogeno basata su prove di efficacia. Agenzia Italiana del Farmaco. Ministero della Salute, Istituto Poligrafico e Zecca dello Stato, Roma 2005.
4. Koren G, Pastuszak A. Prevention of unnecessary pregnancy terminations by counselling women on drug, chemical and radiation exposure during the first trimester. Teratology 1990;41:657-61.
5. Koren G, Bologa G, Long D, et al. Perception of teratogenic risk by pregnant women exposed to drugs and chemicals during the first trimester. Am J Obstet Gynecol 1989; 160:1190-4.
6. Sanz E, Gòmez-Lòpez T, Martinez-Quintas MJ. Perception of teratogenic risk of common medicines. Eur J Obstet Gynecol Reprod Biol 2001;95:127-31.
7. Trasler JM, Doerksen T. Teratogen update: paternal exposures-reproductive risks. Teratology 1999;60:161-72.

Corrispondenza: icbd@icbd.org