Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Antipiretici e convulsioni febbrili: qualcosa di nuovo?

ANTIPIRETICS AND FEBRILE SEIZURES: ANYTHING NEW?

Gianluca Tornese1, Jenny Bua1, Giovanni Simeone2, Federico Marchetti1

1Clinica Pediatrica, IRCCS “Burlo Garofolo”, Trieste
2Pediatra di famiglia, Mesagne (Brindisi)

Dicembre 2009 - pagg. 657 -660

Abstract
The degree of temperature reached during a febrile episode has been considered the main condition of risk for the onset of febrile seizures for many years. In theory, the administration of antipyretics, lowering the body temperature, could prevent convulsions and their recurrence: however, this axiom has never been confirmed. The evidence on the issue of antipyretics and febrile seizures, based on the results of five RCT, requires uniform behaviour according to recommendations contained in the guidelines: the systematic use of antipyretics does not prevent the onset or the recurrence of febrile seizures.
Parole chiave
antipiretici Antipyretics Convulsione febbrile Febbre Febrile convulsion Fever Prevention Treatment
Suggerite dall'AI
Acetaminophen Convulsioni febbrili Febrile seizures Ibuprofen Ibuprofene Paracetamolo
Classificazione MeSH
Organic Chemicals Amines Aniline Compounds Anilides Acetanilides Acetaminophen (25)
Chemical Actions and Uses Pharmacologic Actions Physiological Effects of Drugs Antipyretics (16)
Pathological Conditions, Signs and Symptoms Signs and Symptoms Body Temperature Changes Fever (95)
Organic Chemicals Carboxylic Acids Acids, Carbocyclic Phenylpropionates Ibuprofen (14)
Health Care Quality, Access, and Evaluation Quality of Health Care Health Care Evaluation Mechanisms Epidemiologic Study Characteristics Clinical Studies as Topic Clinical Trials as Topic
Pathological Conditions, Signs and Symptoms Pathologic Processes Disease Attributes Recurrence (99)
Health Care Facilities Workforce and Services Health Services Preventive Health Services Secondary Prevention (9)
Pathological Conditions, Signs and Symptoms Signs and Symptoms Neurologic Manifestations Seizures Seizures, Febrile (41)
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RI Digest
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· 2006
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EL Appunti di Terapia
La mancata risposta della febbre agli antipiretici è indicativa di una malattia severa?
V. Murgia, F. Marchetti · 2013
Antipyretics, Acetaminophen, Fever
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F. Damassa, L. Mambelli, F. Marchetti · 2019
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RI Pagine elettroniche
Chi ha paura della febbre?
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Bibliografia
1. Rantala H, Tarkka R, Uhari M. Systematic review of the role of prostaglandin and their synthetase inhibitors with respect to febrile seizures. Epilepsy Res 2001;46:251-7.
2. Costa P, Marchetti F. Le convulsioni febbrili. Medico e Bambino 2005;24:227-34.
3. Schnaiderman D, Lahat E, Sheefer T, Aladjem M. Antipyretic effectiveness of acetaminophen in febrile seizures: ongoing prophylaxis versus sporadic usage. Eur J Pediatr 1993;152:747-9.
4. Uhari M, Rantala H, Vainionpää L, Kurttila R. Effects of acetaminophen and of low intermittent doses and diazepam on prevention of recurrences of febbrile seizures. J Pediatr 1995;126:991-5.
5. Van Stuijvenberg M, Derksen-Lubsen G, Steyerberg EW, Habbema JD, Moll HA. Randomized, controlled trial of ibuprofen syrup administered during febbrile illnesses to prevent febrile recurrences. Pediatrics 1998;102: 1-7.
6. Van Esch A, Steyerberg EW, Moll HA, et al. A study of the efficacy of antipyretic drugs in the prevention of febrile seizure recurrence. Ambulatory Child Health 2000;6: 19-26.
7. El-Radhi AS, Barry W. Do antipyretics prevent febrile convulsions? Arch Dis Child 2003; 88:641-2.
8. Strengell T, Uhari M, Tarkka R, et al. Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trial. Arch Pediatr Adolesc Med 2009;163:799-804.
9. Clinical Knowledge Summaries-NHS. Febrile seizures. Ultimo aggiornamento: June
2008. http://www.cks.nhs.uk/febrile_seizure# 322556001, ultimo accesso 23 settembre 2009.
10. De Martino M, Principi N. Gestione del segno/ sintomo febbre in pediatria: linee guida della Società Italiana di Pediatria. Min Pediatr 2008;60:489-501.
11. Mastrangelo M, Romeo A, Vigevano F. Recommendations for the management of “febrile seizures”: Ad Hoc Task Force of LICE Guidelines Commission. Epilepsia 2009;50 (Suppl 1):2-6.
12. Steering Committee on Quality Improvement and Management, Subcommitee on Febrile serizures. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics 2008;121:1281-6.
13. Impicciatore P, Nannini S, Pandolfini C, Bonati M. Mother’s knowledge of, attitudes toward, and management of fever in preschool children in Italy. Prev Med 1998;27:268-73.
14. Betz MG, Grunfeld AF. “Fever phobia” in the emergency department: a survey of children’s caregivers. Eur J Emerg Med 2006;13: 129-33.
15. Purssell E. Parental fever phobia and its evolutionary correlates. J Clin Nurs 2009;18: 210-8.
16. Rupe A, Alhers-Schmidt CR, Wittler R. A comparison of perceptions of fever and fever phobia by ethnicity. Clin Pediatr (Phila) 2009 May 15. [Epub ahead of print]

Corrispondenza: tornese@burlo.trieste.it