Problemi correnti
Vaccino anti-morbillo-parotite-rosolia e allergia all’uovo
Finalmente una svolta epocale
MEASLES-MUMPS-RUBELLA VACCINE AND EGG ALLERGY: AN EPOCHAL TURNING-POINT
Irene Berti, Giorgio Longo
Clinica Pediatrica, IRCCS “Burlo Garofolo”, Trieste
Gennaio 2010 - pagg. 36 -40
Abstract
Since measles and mumps components used in measles-mumps-rubella (MMR) vaccine
are grown in cultures of fibroblast from chick embryos, the safety of administering MMR
vaccine to patients allergic to eggs has been debated for long time. Finally international
recommendations and Italian guide line clearly state that MMR vaccine do not contain significant
amounts of egg cross-reacting proteins and so there are no risks for patients allergic
to eggs. Furthermore, children with egg allergy are at low risk of allergic reaction
to MMR, even if they have a history of severe anaphylaxis to egg ingestion: they can be
vaccinated regularly, without previous skin test with the vaccine and the procedure does
not need to be done in a hospital.
Classificazione MeSH
Bibliografia
controindicazioni alle vaccinazioni. Roma: Istituto
Superiore di Sanità, 2009. (Rapporti ISTISAN
09/13) http://www.iss.it/binary/publ/
cont/09_ 13_web.pdf
2. Cerecedo Carballo I, Dieguez Pastor MC, Bartolomè Zavala B, Sanchez Cano M, de la Hoz Caballer B. Safety of measles-mumps-rubella vaccine (MMR) in patients allergic to eggs. Allergol Immunopathol 2007;35:105-9.
3. Khakoo GA, Lack G. Guidelines for measles vaccination in egg-allergic children. Clin Exp Allergy 2000;30:288-293.
4. Khakoo GA, Lack G. Recommendations for using MMR vaccine in children allergic to eggs. BMJ 2000;320:929-32.
5. Department of Health. Health Protection Agency. Immunisation against infectious disease
2006. “The Green Book”. Update 2008. http://www.dh.gov.uk/en/Publichealth/Heal thprotection/Immunisation/Greenbook/ DH_4097254.
6. Circolare Ministero della Salute, Pompa Maria Grazia, DGPREV.V/19483/P/I.4.c.a.9. 25 agosto 2005.
7. Galassi C, De Sario M, Biggeri A, et al. Changes in prevalence of asthma and allergies among children and adolescents in Italy: 1994-
2002. Pediatrics 2006;117:34-42.
8. James JM, Burks AW, Roberson PK, Sampson HA. Safe administration of the measles vaccine to children allergic to eggs. N Engl J Med 1995;332:1262-6.
9. Kwittken PL, Rosen S, Sweinberg SK. MMR vaccine and neomycin allergy. AJDC 1993;147: 128-9.
10. Sakaguchi M, Nakayama T, Inouye S. Food allergy to gelatin in children with systemic immediate- type reactions, including anaphylaxis, to vaccine. J All Clin Immunol 1996;98:1058-61.
11. Kamin W, Staubach P, Klär-Hlawatsch B, Erdnüss F, Knuf M. Anaphylaxis after vaccination due to hypersensitivity to gelatine. Klin Padiatr 2006;218:92-4.
12. James JM, Zeiger RS, Lester MR, Fasano MB, Gern JE, Mansfield LE. Safe administration of influenza vaccine to patients with egg allergy. J Pediatr 1998;133:624-8.
13. Bonifazi F, Jutel M, Bilò MB, Birnbaum J, Muller U, Bucher C. Prevention and treatment of Hymenoptera venom allergy. Allergy 2005;60:1459-70.
14. Red Book 2006. Immunizzazione attiva. Reazioni allergiche all’uovo o ad antigeni a esso legati. p. 37.
15. Departement of Health and Human Service Center for Disease Control and Prevention CDC. 13/3/2008 http://www.cdc.gov/vaccines/ pubs/ vis/ downloads/vis-mmr.pdf.
16. Erlewyn-Lajeunesse M. Recommendations for the administration of influenza vaccine in children allergic to eggs. BMJ 2009;339: b3680.
17. Lack G. Food allergy. N Engl J Med 2008; 359:1252-60.
18. Bierman CW, Chapiro GG, Pierson WE, Taylor JW, Foy HM, Fox JP. Safety of influenza vaccination in allergic children. J Infect Dis 1977;136:S652-5.
19. Red Book 2009. Allergic reactions to eggrelated antigens. Pag. 48-9.
20. Chaloupka I, Schuler A, Marschall M, Meier-Ewert H. Comparative analysis of six European influenza vaccines. Eur J Clin Microbiol Dis 1996;15:121-7.
21. Rank MA, Li JT. Clinical pearls for preventing, diagnosing, and treating seasonal and 2009 H1N1 influenza infection in patients with asthma. J Allergy Clin Immunol 2009;124: 1123-6.
2. Cerecedo Carballo I, Dieguez Pastor MC, Bartolomè Zavala B, Sanchez Cano M, de la Hoz Caballer B. Safety of measles-mumps-rubella vaccine (MMR) in patients allergic to eggs. Allergol Immunopathol 2007;35:105-9.
3. Khakoo GA, Lack G. Guidelines for measles vaccination in egg-allergic children. Clin Exp Allergy 2000;30:288-293.
4. Khakoo GA, Lack G. Recommendations for using MMR vaccine in children allergic to eggs. BMJ 2000;320:929-32.
5. Department of Health. Health Protection Agency. Immunisation against infectious disease
2006. “The Green Book”. Update 2008. http://www.dh.gov.uk/en/Publichealth/Heal thprotection/Immunisation/Greenbook/ DH_4097254.
6. Circolare Ministero della Salute, Pompa Maria Grazia, DGPREV.V/19483/P/I.4.c.a.9. 25 agosto 2005.
7. Galassi C, De Sario M, Biggeri A, et al. Changes in prevalence of asthma and allergies among children and adolescents in Italy: 1994-
2002. Pediatrics 2006;117:34-42.
8. James JM, Burks AW, Roberson PK, Sampson HA. Safe administration of the measles vaccine to children allergic to eggs. N Engl J Med 1995;332:1262-6.
9. Kwittken PL, Rosen S, Sweinberg SK. MMR vaccine and neomycin allergy. AJDC 1993;147: 128-9.
10. Sakaguchi M, Nakayama T, Inouye S. Food allergy to gelatin in children with systemic immediate- type reactions, including anaphylaxis, to vaccine. J All Clin Immunol 1996;98:1058-61.
11. Kamin W, Staubach P, Klär-Hlawatsch B, Erdnüss F, Knuf M. Anaphylaxis after vaccination due to hypersensitivity to gelatine. Klin Padiatr 2006;218:92-4.
12. James JM, Zeiger RS, Lester MR, Fasano MB, Gern JE, Mansfield LE. Safe administration of influenza vaccine to patients with egg allergy. J Pediatr 1998;133:624-8.
13. Bonifazi F, Jutel M, Bilò MB, Birnbaum J, Muller U, Bucher C. Prevention and treatment of Hymenoptera venom allergy. Allergy 2005;60:1459-70.
14. Red Book 2006. Immunizzazione attiva. Reazioni allergiche all’uovo o ad antigeni a esso legati. p. 37.
15. Departement of Health and Human Service Center for Disease Control and Prevention CDC. 13/3/2008 http://www.cdc.gov/vaccines/ pubs/ vis/ downloads/vis-mmr.pdf.
16. Erlewyn-Lajeunesse M. Recommendations for the administration of influenza vaccine in children allergic to eggs. BMJ 2009;339: b3680.
17. Lack G. Food allergy. N Engl J Med 2008; 359:1252-60.
18. Bierman CW, Chapiro GG, Pierson WE, Taylor JW, Foy HM, Fox JP. Safety of influenza vaccination in allergic children. J Infect Dis 1977;136:S652-5.
19. Red Book 2009. Allergic reactions to eggrelated antigens. Pag. 48-9.
20. Chaloupka I, Schuler A, Marschall M, Meier-Ewert H. Comparative analysis of six European influenza vaccines. Eur J Clin Microbiol Dis 1996;15:121-7.
21. Rank MA, Li JT. Clinical pearls for preventing, diagnosing, and treating seasonal and 2009 H1N1 influenza infection in patients with asthma. J Allergy Clin Immunol 2009;124: 1123-6.
Corrispondenza: berti@burlo.trieste.it