Problemi speciali
Convulsioni in corso di gastroenterite lieve
CONVULSIONS WITH MILD GASTROENTERITIS
Giovanni Crichiutti, Ivona Poskurica, Alberto Orioles
Clinica Pediatrica, DPMSC, Azienda Ospedaliero-Universitaria di Udine
Marzo 2010 - pagg. 165 -169
Abstract
Convulsions with mild gastroenteritis (CWG) in small children have been frequently reported
in the Japanese medical literature since 1982 but only recently mentioned in western
countries. Although the diagnosis is one of exclusion, some peculiar clinical features suggest
a common pathophysiological mechanism, albeit unknown. Nevertheless its benign
clinical evolution without treatment renders knowledge of this association worthwhile for
paediatricians. Three cases that seem particularly significant of this clinical entity are presented
and the relevant literature is briefly reviewed.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
1. Ushijima H, Bosu K, Abe T, Shinozaki T.
Suspected rotavirus encephalitis. Arch Dis
Child 1986;61:692-4.
2. Shihara T, Watanabe M, Honma A, et al. Rotavirus associated acute encephalitis/ encephalopathy and concurrent cerebellitis: Report of two cases. Brain Dev 2007;29: 670-3.
3. Goldwater PN, Krowland K, Power R, et al. Rotavirus encephalopathy: Pathogenesis reviewed. J Paediatr Child Health 2001;37: 206-9.
4. Natsume J, Naiki M, Yokotsuka T, et al. Transient splenial lesions in children with “benign convulsions with gastroenteritis”. Brain Dev 2007;29:519-21.
5. Di Fazio MP, Broun L, Freedman S, Hickey P. Rotavirus-induced seizures in childhood. J Child Neurol 2007;22:1367-70.
6. Uemura N, Okumura A, Negoro T, Watanabe K. Clinical features of benign convulsions with mild gastroenteritis. Brain Dev 2002;24:745-9.
7. Lynch M, Lee B, Azimi P, et al. Rotavirus and CNS symptoms: Cause or concomitant? Clin Infect Dis 2001;33:932-8.
8. Komori H, Wada M, Eto M, Oki H, Aida K, Fujimoto T. Benign convulsions with mild gastroenteritis: a report of 10 recent cases detailing clinical varieties. Brain Dev 1995; 17:344-7.
9. Kawano G, Oshige K, Syutou S, et al. Benign infantile convulsions associated with mild gastroenteritis: A retrospective study of 39 cases including virological tests and efficacy of anticonvulsants. Brain Dev 2007;29: 617-22.
10. Abe T, Kobayashi M, Araki K, et al. Infantile convulsions with mild gastroenteritis. Brain Dev 2000;22:301-6.
11. Narchi H. Benign afebrile cluster convulsions with gastroenteritis: an observational study. BMC Pediatrics 2004;4:2.
12. Ben-Ami T, Sinai L, Granot E. Afebrile seizures and rotavirus gastroenteritis: an infrequently recognized association. Clin Pediatr (Phila) 2007;46:178-80.
13. Chalouhi C, Bernerias C, Abadie V. Afebrile seizures in gastroenteritis: a Japanese peculiarity. Arch Pediatr 2006;13:266-8.
14. Maruyama K, Okumura A, Sofu A, Ishihara N, Watanabe K. Ictal EEG in patients with convulsions with mild gastroenteritis. Brain Dev 2007;29:43-6.
15. Isik U, Caliskan M. Reversible EEG changes during rotavirus gastroenteritis. Brain Dev 2008;30:73-6.
16. Imai K, Otani K, Yanagihara K, et al. Ictal Video-EEG recording of three par tial seizures in a patient with the benign infantile convulsions associated with mild gastroenteritis. Epilepsia 1999;40:1455-8.
17. Specchio N, Vigevano F. The spectrum of benign infantile seizures. Epilepsy Res 2006; S70:156-7.
18. Enoki H, Yokota T, Nagasaki R, et al. Single- dose chloral hydrate for benign convulsions with mild gastroenteritis. Epilepsia 2007;48:1026-8.
19. Hattori H, Yaano T, Hayashi K, et al. Effectiveness of lidocaine infusion for status epilepticus in childhood: A retrospective multi- institutional study in Japan. Brain Dev 2008;30:504-12.
20. Iturriza-Gòmara M, Auchterlonie A, Zaw W, Molyneaux P, Desselberger U, Gray J. Rotavirus gastroenteritis and CNS infection: Characterization of the VP7 and VP4 genes of Rotavirus strains isolated from paired fecal and cerebrospinal fluid samples from a child with CNS disease. J Clin Microbiol 2002;40: 4797-9.
21. Sugata K, Taniguchi K, Yui A, et al. Analysis of Rotavirus antigenemia and extraintestinal manifestations in children with Rotavirus gastroenteritis. Pediatrics 2008;122:392-7.
22. Mossel EC, Ramig RF. A lymphatic mechanism of Rotavirus extraintestinal spread in the neonatal mouse. J Virol 2003;77:12352-6.
23. Wong V. Acute gastroenteritis-related encephalopathy. J Child Neurol 2001;16:906-10.
24. Wei-Ling Lee, Hian-Tat Ong. Afebrile seizures associated with minor infections: comparisons with febrile seizures and unprovoked seizures. Pediatr Neurol 2004;31:157- 64.
25. Iyadurai S, Troester M, Harmala J, Bodensteiner J. Benign afebrile seizures in acute gastroenteritis: is rotavirus the culprit? J Child Neurol 2007;22:887-90.
26. Sakai Y, Kira R, Torisu H, et al. Benign convulsion with mild gastroenteritis and benign familial infantile seizure. Epilepsy Res 2006;68:269-71.
27. Zerr DM, Blume HK, Berg AT, et al. Non febrile illness seizures: A unique seizure category? Epilepsia 2005;46:952-5.
2. Shihara T, Watanabe M, Honma A, et al. Rotavirus associated acute encephalitis/ encephalopathy and concurrent cerebellitis: Report of two cases. Brain Dev 2007;29: 670-3.
3. Goldwater PN, Krowland K, Power R, et al. Rotavirus encephalopathy: Pathogenesis reviewed. J Paediatr Child Health 2001;37: 206-9.
4. Natsume J, Naiki M, Yokotsuka T, et al. Transient splenial lesions in children with “benign convulsions with gastroenteritis”. Brain Dev 2007;29:519-21.
5. Di Fazio MP, Broun L, Freedman S, Hickey P. Rotavirus-induced seizures in childhood. J Child Neurol 2007;22:1367-70.
6. Uemura N, Okumura A, Negoro T, Watanabe K. Clinical features of benign convulsions with mild gastroenteritis. Brain Dev 2002;24:745-9.
7. Lynch M, Lee B, Azimi P, et al. Rotavirus and CNS symptoms: Cause or concomitant? Clin Infect Dis 2001;33:932-8.
8. Komori H, Wada M, Eto M, Oki H, Aida K, Fujimoto T. Benign convulsions with mild gastroenteritis: a report of 10 recent cases detailing clinical varieties. Brain Dev 1995; 17:344-7.
9. Kawano G, Oshige K, Syutou S, et al. Benign infantile convulsions associated with mild gastroenteritis: A retrospective study of 39 cases including virological tests and efficacy of anticonvulsants. Brain Dev 2007;29: 617-22.
10. Abe T, Kobayashi M, Araki K, et al. Infantile convulsions with mild gastroenteritis. Brain Dev 2000;22:301-6.
11. Narchi H. Benign afebrile cluster convulsions with gastroenteritis: an observational study. BMC Pediatrics 2004;4:2.
12. Ben-Ami T, Sinai L, Granot E. Afebrile seizures and rotavirus gastroenteritis: an infrequently recognized association. Clin Pediatr (Phila) 2007;46:178-80.
13. Chalouhi C, Bernerias C, Abadie V. Afebrile seizures in gastroenteritis: a Japanese peculiarity. Arch Pediatr 2006;13:266-8.
14. Maruyama K, Okumura A, Sofu A, Ishihara N, Watanabe K. Ictal EEG in patients with convulsions with mild gastroenteritis. Brain Dev 2007;29:43-6.
15. Isik U, Caliskan M. Reversible EEG changes during rotavirus gastroenteritis. Brain Dev 2008;30:73-6.
16. Imai K, Otani K, Yanagihara K, et al. Ictal Video-EEG recording of three par tial seizures in a patient with the benign infantile convulsions associated with mild gastroenteritis. Epilepsia 1999;40:1455-8.
17. Specchio N, Vigevano F. The spectrum of benign infantile seizures. Epilepsy Res 2006; S70:156-7.
18. Enoki H, Yokota T, Nagasaki R, et al. Single- dose chloral hydrate for benign convulsions with mild gastroenteritis. Epilepsia 2007;48:1026-8.
19. Hattori H, Yaano T, Hayashi K, et al. Effectiveness of lidocaine infusion for status epilepticus in childhood: A retrospective multi- institutional study in Japan. Brain Dev 2008;30:504-12.
20. Iturriza-Gòmara M, Auchterlonie A, Zaw W, Molyneaux P, Desselberger U, Gray J. Rotavirus gastroenteritis and CNS infection: Characterization of the VP7 and VP4 genes of Rotavirus strains isolated from paired fecal and cerebrospinal fluid samples from a child with CNS disease. J Clin Microbiol 2002;40: 4797-9.
21. Sugata K, Taniguchi K, Yui A, et al. Analysis of Rotavirus antigenemia and extraintestinal manifestations in children with Rotavirus gastroenteritis. Pediatrics 2008;122:392-7.
22. Mossel EC, Ramig RF. A lymphatic mechanism of Rotavirus extraintestinal spread in the neonatal mouse. J Virol 2003;77:12352-6.
23. Wong V. Acute gastroenteritis-related encephalopathy. J Child Neurol 2001;16:906-10.
24. Wei-Ling Lee, Hian-Tat Ong. Afebrile seizures associated with minor infections: comparisons with febrile seizures and unprovoked seizures. Pediatr Neurol 2004;31:157- 64.
25. Iyadurai S, Troester M, Harmala J, Bodensteiner J. Benign afebrile seizures in acute gastroenteritis: is rotavirus the culprit? J Child Neurol 2007;22:887-90.
26. Sakai Y, Kira R, Torisu H, et al. Benign convulsion with mild gastroenteritis and benign familial infantile seizure. Epilepsy Res 2006;68:269-71.
27. Zerr DM, Blume HK, Berg AT, et al. Non febrile illness seizures: A unique seizure category? Epilepsia 2005;46:952-5.
Corrispondenza: crichiutti.giovanni@aoud.sanita.fvg.it