Farmacoriflessioni
Antistaminici e allattamento al seno
ANTIHISTAMINES AND BREASTFEEDING
Riccardo Davanzo, Chiara Oretti, Laura Rubert, Ippolita Roncoroni
1Neonatologia e Terapia Intensiva Neonatale, IRCCS “Burlo Garofolo”, Trieste
2Scuola di Specializzazione in Pediatria, Universitŕ di Trieste
3Pediatra di famiglia, Pavia
Marzo 2010 - pagg. 179 -184
Abstract
The safety profile of antihistamines during breastfeeding is largely variable. New second
generation antihistamines are preferable because of reduced side effects on the central nervous
system and heart. Among old first generation antihistamines, hydroxyzine, diphenhydramine
and promethazine could be regarded as a first choice during breastfeeding.
Parole chiave
Classificazione MeSH
Bibliografia
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2. Shank JJ, Olney SC, Lin FL, et al. Recurrent postpartum anaphylaxis with breast-feeding. Obstet Gynecol 2009;114:415-6.
3. Einarson A, Portnoi G, Koren G. Update on mother risk. Seven years of questions and answers. Canadian Fam Physician 2002;48:1301-4.
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6. Hanrahan JP, Choo PW, Carlson W, Greineder D, Faich GA, Platt R. Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. Ann Epidemiol 1995;5:201-9.
7. Ten Eick AP, Blumer JL, Reed MD. Safety of antihistamines in children. Drug Saf 2001;24: 119-47.
8. Pratt WR. Allergic diseases in pregnancy and breast feeding. Ann Allergy 1981;47:355- 60.
9. Solhaug V, Roland PD. Use of antihistaminics during pregnancy and breast feeding. Tidsskr Nor Laegeforen 2004;124:1390-1.
10. Schatz M. H1 antihistamines in pregnancy and lactation. Clin Allergy Immunol 2002;17: 421-36.
11. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol 1993;168:1393-9.
12. American Academy of Paediatrics. Committee on Drugs. The transfer of Drugs and Other Chemicals into Human Milk. Pediatrics 2001;108:776-89.
13. WHO-UNICEF. Department of Child and Adolescent Health and Development. Breastfeeding and Maternal Medication. Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. UNICEF/ WHO. Geneva, 2002.
14. AIFA. Guida all’uso dei farmaci. Edizione N° 5, 2008.
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17. Royal College of Paediatricians and Child Health. Medicine for Children. RCPCH Publications Ltd.
18. Hale W. Medication and Mother Milk. 13th Edition. Hale Publishing, Amarillo (TX), 2008.
19. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation, 8th Ed. Lippincot, Williams and Wilkins, 2008.
20. http://toxnet.nlm.nih.gov/index.html
21. Messinis IE, Souvatzoglou A, Fais N. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest 1985;8:143-6.
22. Wortsman J, Soler NG, Hirschowitz J. Cyproheptadine in the management of the galactorrhea- amenorrhea syndrome. Ann Intern Med 1979;90:923-5.
23. Kok TH, Taitz LS, Bennett MJ, et al. Drowsiness due to clemastine transmitted in breast milk. Lancet 1982;1:914-5.
24. Khan A, Blim D. Phenothiazines and SIDS. Pediatrics 1982;70:75-8.
25. McKelvey GM, Post EJ, Jeffery HE, Wood AK. Sedation with promethazine profoundly affects spontaneous airway protection in sleeping neonatal piglets. Clin Exp Pharmacol Physiol 1999;26:920-6.
26. Findlay JW, Butz RF, Sailstad JM, Warren JT, Welch RM. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol 1984;18:901-6.
27. Mitchell JL. Use of cough and cold preparations during breastfeeding. J Hum Lact 1999;15:347-9.
28. Powell RJ, Du Toit GL, Siddique N, et al. British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy 2007;37:631-50.
29. Hilbert J, Radwanski E, Affrime MB, et al. Excretion of loratadine in human breast milk. J Clin Pharmacol 1988;28:234-9.
30. Boccazzi A, Pugni L, Cesuti R. Oxatomide in the treatment of atopic dermatitis. Minerva Pediatr 2001;53:265-9.
31. Dani C, Martelli E, Bertini G, et al. Pharmacokinetics of oxatomide in preterm infants. Drugs Exp Clin Res 2002;28:207-10.
32. Lucas BD jr, Purdy CY, Scarim SK, et al. Terfenadine pharmacokinetics in breast milk in lactating women. Clin Pharmacol Ther 1995;57:398-402.
33. Ghaeli P, Kaufman MB. Oral antihistamines/ decongestants and breastfeeding. J Hum Lact 1993;9:261-2.
34. Leimgruber A. Treatment of asthma and rhinitis during pregnancy and breast feeding. Rev Med Suisse 2007;3:1044-6,1048-9.
35. Spencer JP, Gonzales LJ, Barnhart DJ. Medication in the breastfeeding mother. Am Fam Physician 2001;64:119-26.
2. Shank JJ, Olney SC, Lin FL, et al. Recurrent postpartum anaphylaxis with breast-feeding. Obstet Gynecol 2009;114:415-6.
3. Einarson A, Portnoi G, Koren G. Update on mother risk. Seven years of questions and answers. Canadian Fam Physician 2002;48:1301-4.
4. Hardman JG, Limbird LE, Gilman AG (Eds). Goodman and Gilman’s. The Pharmacological Basis of Therapeutics. 11th Edition. McGraw Hill, 2006.
5. Zechnich AD, Hedges JR, Eiselt-Proteau D, Haxby D. Possible interactions with terfenadine or astemizole. West J Med 1994;160:321-5.
6. Hanrahan JP, Choo PW, Carlson W, Greineder D, Faich GA, Platt R. Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. Ann Epidemiol 1995;5:201-9.
7. Ten Eick AP, Blumer JL, Reed MD. Safety of antihistamines in children. Drug Saf 2001;24: 119-47.
8. Pratt WR. Allergic diseases in pregnancy and breast feeding. Ann Allergy 1981;47:355- 60.
9. Solhaug V, Roland PD. Use of antihistaminics during pregnancy and breast feeding. Tidsskr Nor Laegeforen 2004;124:1390-1.
10. Schatz M. H1 antihistamines in pregnancy and lactation. Clin Allergy Immunol 2002;17: 421-36.
11. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol 1993;168:1393-9.
12. American Academy of Paediatrics. Committee on Drugs. The transfer of Drugs and Other Chemicals into Human Milk. Pediatrics 2001;108:776-89.
13. WHO-UNICEF. Department of Child and Adolescent Health and Development. Breastfeeding and Maternal Medication. Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. UNICEF/ WHO. Geneva, 2002.
14. AIFA. Guida all’uso dei farmaci. Edizione N° 5, 2008.
15. British National Formulary (BNF) 55, March 2008.
16. Ministero della Salute. Direzione Generale della valutazione dei Medicinali e della Farmacovigilanza. Guida all’uso dei farmaci per i bambini. Roma, 2003.
17. Royal College of Paediatricians and Child Health. Medicine for Children. RCPCH Publications Ltd.
18. Hale W. Medication and Mother Milk. 13th Edition. Hale Publishing, Amarillo (TX), 2008.
19. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation, 8th Ed. Lippincot, Williams and Wilkins, 2008.
20. http://toxnet.nlm.nih.gov/index.html
21. Messinis IE, Souvatzoglou A, Fais N. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest 1985;8:143-6.
22. Wortsman J, Soler NG, Hirschowitz J. Cyproheptadine in the management of the galactorrhea- amenorrhea syndrome. Ann Intern Med 1979;90:923-5.
23. Kok TH, Taitz LS, Bennett MJ, et al. Drowsiness due to clemastine transmitted in breast milk. Lancet 1982;1:914-5.
24. Khan A, Blim D. Phenothiazines and SIDS. Pediatrics 1982;70:75-8.
25. McKelvey GM, Post EJ, Jeffery HE, Wood AK. Sedation with promethazine profoundly affects spontaneous airway protection in sleeping neonatal piglets. Clin Exp Pharmacol Physiol 1999;26:920-6.
26. Findlay JW, Butz RF, Sailstad JM, Warren JT, Welch RM. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol 1984;18:901-6.
27. Mitchell JL. Use of cough and cold preparations during breastfeeding. J Hum Lact 1999;15:347-9.
28. Powell RJ, Du Toit GL, Siddique N, et al. British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy 2007;37:631-50.
29. Hilbert J, Radwanski E, Affrime MB, et al. Excretion of loratadine in human breast milk. J Clin Pharmacol 1988;28:234-9.
30. Boccazzi A, Pugni L, Cesuti R. Oxatomide in the treatment of atopic dermatitis. Minerva Pediatr 2001;53:265-9.
31. Dani C, Martelli E, Bertini G, et al. Pharmacokinetics of oxatomide in preterm infants. Drugs Exp Clin Res 2002;28:207-10.
32. Lucas BD jr, Purdy CY, Scarim SK, et al. Terfenadine pharmacokinetics in breast milk in lactating women. Clin Pharmacol Ther 1995;57:398-402.
33. Ghaeli P, Kaufman MB. Oral antihistamines/ decongestants and breastfeeding. J Hum Lact 1993;9:261-2.
34. Leimgruber A. Treatment of asthma and rhinitis during pregnancy and breast feeding. Rev Med Suisse 2007;3:1044-6,1048-9.
35. Spencer JP, Gonzales LJ, Barnhart DJ. Medication in the breastfeeding mother. Am Fam Physician 2001;64:119-26.
Corrispondenza: davanzor@burlo.trieste.it