Aggiornamento
Nuovi patogeni respiratori
NEW RESPIRATORY PATHOGENS
Massimiliano Don1, Mario Canciani2
1UOC di Pediatria, Presidio Ospedaliero “Sant’Antonio”, San Daniele del Friuli, Udine
2Servizio di Allergo-Pneumologia Pediatrica, Clinica Pediatrica, DPMSC, Universitŕ di Udine
Giugno 2010 - pagg. 363 -370
Abstract
Acute respiratory infections represent the most common disease during childhood in both
developing and developed countries and although the majority of these infections are limited
to the upper respiratory tract, lower respiratory tract infections are the main cause
of morbidity, mortality and hospitalization in infancy all over the world. The etiology of respiratory
infections often remains unknown, thus suggesting that unknown respiratory
pathogens have existed for a long time, even though the negative findings and the variability
in agent-specific incidence rates also depend on methodological differences of the
published studies. Determining the etiology of these diseases is a problem in the pediatric
age, because obtaining adequate samples for the microbiological detection is not often simple
and many diagnostic tests are not always sensitive enough to identify the etiological
agent. Recent progress in epidemiological research and in molecular biology, as the introduction
of polymerase chain reaction performed on samples from the upper respiratory
tract in which viruses and atypical bacteria are not commensal, has enabled the quick recognition
and identification of many respiratory emerging pathogens. The present review
firstly introduces some of the new recent respiratory pathogens, then focuses on three individual
“emerging” and “new” viral and bacterial microorganisms, such as Simkania negevensis,
human metapneumovirus and human bocavirus.
Parole chiave
Classificazione MeSH
Bibliografia
1. Zar HJ, Mulholland K. Global burden of Pediatric Respiratory Illness and the implications for management and prevention. Ped Pulmonol 2003;36:457-61.
2. Monto AS. Epidemiology of viral respiratory infections. Am J Med 2002;112(suppl 6A): 4S-12S.
3. Williams BG, Gouws E, Baschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infect Dis 2002;2:25-32.
4. Glezen WP, Loda FA, Clyde WA, et al. Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice. J Pediatr 1971;78:397-406.
5. Jennings LC, Anderson TP, Werno AM, Beynon KA, Murdoch DR. Viral etiology of acute respiratory tract infections in children presenting to hospital: role of polymerase chain reaction and demostration of multiple infections. Pediatr Infect Dis J 2004;23:1003-7.
6. British Thoracic Society of Standards of Care Committee BTS Guidelines for the management of community acquired pneumonia in childhood. Thorax 2002;57:1-24.
7. Louie JK, Hacker JK, Gonzales R, et al. Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season. Clin Infect Dis 2005;41:822-8.
8. Arnold JC, Singh KK, Spector SA, Sawyer MH. Human bocavirus: prevalence and clinical spectrum at a children’s hospital. Clin Infect Dis 2006;43:283-8.
9. Fredericks DN, Relman DA. Sequence-based identification of microbial pathogens: a reconsideration of Koch’s postulates. Clin Microbiol Rev 1996;9:18-33.
10. Duchin JS, Koster FT, Peters CJ, et al. Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The Hantavirus Study Group. N Engl J Med 1994;330:949-55.
11. Selvey LA, Wells RM, McCormack JG, et al. Infection of humans and horses by a newly described morbillivirus. Med J Aust 1995;162: 642-5.
12. Centers for Disease Control and Prevention (CDC). Update: outbreak of Nipah virus- Malaysia and Singapore, 1999. MMWR Morb Mortal Wkly Rep 1999;48:335-7.
13. Tyrrel DA, Bynoe ML. Cultivation of a novel type of common-cold virus in organ cultures. BMJ 1965;5448:1467-70.
14. Tsang KW, Ho PL, Ooi GC, et al. A cluster of cases of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003;348:1977- 85.
15. El-Sahly HM, Atmar RL, Glezen WP, Greenberg SB. Spectrum of clinical illness in hospitalised patients with “Common Cold” virus infection. Clin Infect Dis 2000;31:96-100.
16. Vabret A, Mourez T, Gouarin S, Petitjean J, Freymuth F. An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin Infect Dis 2003;36:985-9.
17. van der Hoek L, Pyrc K, Jebbink MF, et al. Identification of a new human coronavirus. Nat Med 2004;10:368-73.
18. Woo PC, Lau SK, Chu CM, et al. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol 2005;79:884- 95.
19. Ungchusak K, Auewarakul P, Dowell SF, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 2005;352:333-40.
20. Grose C, Chokephaibulkit K. Avian influenza virus infection of children in Vietnam and Thailand. Pediatr Infect Dis J 2004;23:793- 4.
21. Baden LR, Drazen JM, Kritek PA, Curfman GD, Morrissey S, Campion EW. H1N1 influenza A disease-information for health professionals. N Engl J Med 2009;360:2666-7.
22. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009;360:2605-15.
23. Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med 2009;361: 680-9.
24. Chowell G, Bertozzi SM, Colchero MA, et al. Severe respiratory disease concurrent with the circulation of H1N1 influenza. N Engl J Med 2009;361:674-9.
25. www.ministerosalute.it.
26. Don M, Canciani M. Nuovi patogeni delle infezioni respiratorie infantili e loro ruolo nella malattia asmatica. Asma & Allergia 2009;25: 5-15.
27. van den Hoogen BG, de Jong JC, Groen J, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 2001;7:719-24.
28. Crowe JE. Human metapneumovirus as a major cause of human respiratory tract disease. Pediatr Infect Dis J 2004;23:S215-21.
29. van den Hoogen BG, Osterhaus DM, Fouchier RA. Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 2004;23(1 Suppl):S25-32.
30. Principi N, Bosis S, Esposito S. Human metapneumovirus in paediatric patients. Clin Microbiol Infect 2006;12:301-8.
31. Boivin G, De Serres G, Côté S, et al. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis 2003;9:634- 40.
32. Maggi F, Pifferi M, Vatteroni M, et al. Human metapneumovirus associated with respiratory tract infections in a 3-year study of nasal swabs from infants in Italy. J Clin Microbiol 2003;41:2987-91.
33. Ebihara T, Endo R, Kikuta H, et al. Seroprevalence of human metapneumovirus in Japan. J Med Virol 2003;70:281-3.
34. Leung J, Esper F, Weibel C, Kahn JS. Seroepidemiology of human metapneumovirus (hMPV) on the basis of a novel enzyme-linked immunosorbent assay utilizing hMPV fusion protein expressed in recombinant vesicular stomatitis virus. J Clin Microbiol 2005;43: 1213-9.
35. Alto WA. Human metapneumovirus: a newly described respiratory tract pathogen. J Am Board Fam Pract 2004;17:466-9.
36. Williams JV, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 2004;350:443-50.
37. Dřllner H, Risnes K, Radtke A, Nordbř SA. Outbreak of human metapneumovirus infection in norwegian children. Pediatr Infect Dis J 2004;23:436-40.
38. Don M, Fasoli L, Paldanius M, et al. Aetiology of community-acquired pneumonia: serological results of a paediatric survey. Scand J Infect Dis 2005;37:806-12.
39. Don M, Korppi M, Valent F, Vainionpaa R, Canciani M. Human metapneumovirus pneumonia in children: results of an Italian study and mini-review. Scand J Infect Dis 2008;40: 821-6.
40. Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA 2005;102:12891-6.
41. Allander T, Jartti T, Gupta S, et al. Human bocavirus and acute wheezing in children. Clin Infect Dis 2007;44:904-10.
42. Kantola K, Hedman L, Allander T, et al. Serodiagnosis of human bocavirus infection. Clin Infect Dis 2008;46:540-6.
43. Söderlund-Venermo M, Lahtinen A, Jartti T, et al. Clinical Assessment and Improved Diagnosis of Bocavirus-induced Wheezing in Children, Finland. Emerg Infect Dis 2009;15: 1423-30.
44. Allander T. Human bocavirus. J Clin Virol 2008;41:29-33.
45. Kesebir D, Vazquez M, Weibel C, et al. Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. J Infect Dis 2006; 194:1276-82.
46. Brieu N, Gay B, Segondy M, Foulongne V. Electron microscopy observation of human bocavirus (HBoV) in nasopharyngeal samples from HBoV-infected children. J Clin Microbiol 2007;45:3419-20.
47. Fry AM, Lu X, Chittaganpitch M, et al. Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand. J Infect Dis 2007; 195:1038-45.
48. Endo R, Ishiguro N, Kikuta H, et al. Seroepidemiology of human bocavirus in Hokkaido prefecture, Japan. J Clin Microbiol 2007;45: 3218-23.
49. Kahn JS, Kesebir D, Cotmore SF et al. Seroepidemiology of Human Bocavirus Defined Using Recombinant Virus-Like Particles. J Infect Dis 2008;198:41-50.
50. Lin F, Guan W, Cheng F, Yang N, Pintel D, Qiu J. ELISAs using human bocavirus VP2 virus- like particles for detection of antibodies against HBoV. J Virol Methods 2008;149:110-7.
51. Vallet C, Pons-Catalano C, Mandelcwajg A, et al. Human bocavirus: a cause of severe asthma exacerbation in children. J Pediatr 2009; 155:286-8.
52. Vicente D, Cilla G, Montes M, Pérez-Yarza EG, Pérez-Trallero E. Human bocavirus, a respiratory and enteric virus. Emerg Infect Dis 2007;13:636-7.
53. Don M, Sorelund-Venermo M, Valent F, et al. Serologically verified human bocavirus pneumonia in children. Pediatr Pulmonol 2010;45:120-6.
54. Korppi M. Mixed viral-bacterial aetiology of community-acquired pneumonia in children. APMIS 2002;110:515-22.
55. Kahane S, Everett KD, Kimmel N, Friedman MG. Simkania negevensis strain ZT: growth, antigenic and genome characteristics. Int J Syst Bacteriol 1999;49:815-20.
56. Friedman MG, Dvoskin B, Kahane S. Infections with the Chlamydia-like microorganism Simkania negevensis, a possible emerging pathogen. Microb Infect 2003;5:1013-21.
57. Kahane S, Kimmel N, Friedman MG. The growth cycle of Simkania negevensis. Microbiol 2002;148:735-42.
58. Kahane S, Friedman MG. Antibiotic sensitivity in vitro of Simkania negevensis. In: Saikku P (Ed). Proceedings of the Fourth Meeting of the European Society for Chlamydia research. Bologna: Editrice Esculapio, 2000:397.
59. Kahane S, Greenberg D, Friedman MG, Haikin H, Dagan R. High prevalence of “Simkania Z”, a novel Chlamydia-like bacterium, in infants with acute bronchiolitis. J Infect Dis 1998;177:1425-9.
60. Greenberg D, Banerji A, Friedman MG, Chiu CH, Kahane S. High rate of Simkania negevensis among Canadian Inuit infants hospitalized with lower respiratory tract infections. Scand J Infect Dis 2003;35:506-8.
61. Korppi M, Paldanius M, Hyvärinen A, Nevalainen A. Simkania negevensis and newly diagnosed asthma: a case-control study in 1- to 6-year-old children. Respirology 2006;11: 80-3.
62. Quinn TC, Gaydos CA. In vitro infection and pathogenesis of Chlamydia pneumoniae in endovascular cells. Am Heart J 1999;138: S507-11.
63. Fasoli L, Paldanius M, Don M, et al. Simkania negevensis in community-acquired pneumonia in Italian children. Scand J Infect Dis 2008;40:269-72.
64. Kumar S, Kahlhoff SA, Gelling M, et al. Infection with Simkania negevensis in Brooklin, New York. Pediatr Infect Dis J 2005;24:989-92.
65. Nascimento-Carvalho CM, Cardoso MR, Paldanius M, et al. Simkania negevensis infection among Brazilian children hospitalized with community-acquired pneumonia. J Infect 2009;58:250-3.
66. Gaynor AM, Nissen MD, Whiley DM, et al. Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathog 2007;3:e64.
67. Allander T, Andreasson K, Gupta S, et al. Identification of a third human polyomavirus. J Virol 2007;81:4130-6.
Corrispondenza: max.don@libero.it