Problemi correnti
L’epatopatia della malattia celiaca: uno spettro
di lesioni con una comune patogenesi?
CELIAC DISEASE AND THE LIVER
Silvia Caprai, Giuseppe Maggiore
Clinica Pediatrica II, Dipartimento di Pediatria, Azienda Ospedaliero-Universitaria Pisana
Giugno 2010 - pagg. 383 -386
Abstract
A wide spectrum of liver injuries in children and adults may be related to celiac disease
(CD) and in particular: 1) a mild parenchymal damage characterized by absence of clinical
sign or symptom of a chronic liver disease and by non-specific histological changes
reversible on a gluten-free diet; 2) a chronic inflammatory liver injury of autoimmune mechanism,
including autoimmune hepatitis, primary sclerosing cholangitis and primary biliary
cirrhosis, which may lead to fibrosis and cirrhosis, generally unaffected by gluten withdrawal
and necessitating an immunosuppressive treatment; 3) a severe liver failure potentially
treatable by a gluten-free diet. Such different types of liver injuries may represent
a spectrum of a same disorder where individual factors, such as genetic predisposition, precocity
and duration of exposure to gluten may influence the reversibility of liver damage.
A rigorous cross-checking for an asymptomatic liver damage in CD individuals and, conversely,
for CD in any cryptogenic liver disorder including end-stage liver failure is recommended.
Classificazione MeSH
Bibliografia
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Corrispondenza: g.maggiore@clp.med.unipi.it