Farmacoriflessioni
Cautele sull’uso dei FANS nei bambini
CAUTION ON THE USE OF NSAIDS IN CHILDREN: RECOMMENDATIONS BY THE PAEDIATRIC WORKING GROUP OF AIFA (ITALIAN DRUG AGENCY)
Working Group Pediatrico dell’AIFA
Dicembre 2010 - pagg. 654 -656
Abstract
In the last few years, reports on adverse drug reactions (ADRs) to NSAIDs in paediatric
age, especially to ibuprofen and ketoprofen, have remarkably increased. As to the most
prescribed ibuprofen, reports (rash, rectal haemorrhage and acute kidney insufficiency)
on ADRs have reached 1.7/100,000 paediatric boxes in 2010. Among such ADRs are
6 cases of acute kidney insufficiency (interstitial nephritis). Therefore, the Paediatric
Working Group of AIFA gives the following recommendations: do not use antipyretics to
treat fever alone, but to treat fever and malaise; choose either paracetamol or ibuprofen,
do not use them combined; avoid to use ibuprofen in chickenpox and in dehydration;
calculate drug dosage in relation to weight and not to age. There is no published
study that has demonstrated the efficacy of NSAIDs in reducing the duration of the
symptomatology of respiratory infections; thus, their use, with a presumed curative purpose,
is highly advised against in respiratory infections.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
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Corrispondenza: f.rocchi@aifa.gov.it