Farmacoriflessioni
Gli inibitori del TNF alfa nella cura delle malattie infiammatorie croniche: luci e ombre
TNF alpha inhibitors for chronic inflammatory disorders: lights and shadows
Giulia Gortani, Stefano Martelossi, Loredana Lepore
Clinica Pediatrica, IRCCS Pediatrico “Burlo Garofolo”, Trieste
Maggio 2012 - pagg. 314 -321
Abstract
The present article descibes the use of TNF inhibitors in paediatrics, with special focus on etanercept,
infliximab and adalimumab. Their molecular structure and mechanism of action are
accurately described. Licensed and sperimental applications are discussed, with particular
reference to rheumatic and gastroenterological field. Side effects in the short and long term
are referred and the cost-effectiveness of anti-TNF drugs is taken into account. The article will
show how etanercept in rheumatology and infliximab in gastroenterology have given new
hope to patients with inflammatory diseases refractory to other treatments
Parole chiave
Classificazione MeSH
Bibliografia
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Corrispondenza: ggortani@hotmail.com
