Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Insufficienza epatica acuta, un’evenienza rara... ma non troppo

Acute liver failure, a rare occurrence… but not too rare

Carlo Ripoli, Anna Paola Pinna, Maria Furno, Daniela Congiu, Sara Pusceddu, Maria Laura Fenu

Clinica Pediatrica I, Ospedale San Giovanni di Dio, Cagliari

Ottobre 2012 - pagg. 515 -517

Abstract
Acute liver failure is a rare and complex disease that may present with a worsening course and needs a rational diagnostic and therapeutic intervention, in order to avoid most dangerous complications such as encephalopathy and metabolic changes, which may quickly lead to exitus. Often the only treatment is liver transplantation that can be performed if negative prognosis signs are recognised with appropriate timing and if the patient is promptly sent to an appropriate centre. The paper presents two cases that had similar diagnosis, but different treatment and prognosis.

Bibliografia

1. Lee WM, Squires RH Jr, Nyberg SL, Doo E, Hoofnagle JH. Acute Liver Failure: summary of a workshop. Hepatology 2008;47:1401-15. 2. Narkewicz MR, Dell Olio D, Karpen SJ, et al.; Pediatric Acute Liver Failure Study Group. Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement. J Pediatr 2009;155: 801-6. 3. Squires RH Jr, Shneider BL, Bucuvalas J, et al. Acute liver failure in children: the first 348 patients in the Pediatric Acute Liver Failure Study Group. J Pediatr 2006;148:652-8. 4. Mousaki M, Ng VL. Acute liver failure in children. Pediatr Emerg Med 2010;11:198-206. 5. Durand P, Debray D, Mandel R, et al. Acute liver failure in infancy: a 14-year experience of a pediatric liver transplantation center. J Pediatr 2001;139:871-6. 6. Dhawan A, Cheeseman P, Mieli-Vergani G. Approaches to acute liver failure in children. Pediatr Transplant 2004;8:584-8. 7. Lu BR, Gralla J, Liu E, Dobyns EL, Narkewicz MR, Sokol RJ. Evaluation of a scoring system for assessing prognosis in pediatric acute liver failure. Clin Gastroenterol Hepatol 2008;6:1140-5.

Corrispondenza: annapaola_pinna@yahoo.it