Ricerca
La sindrome mononucleosica: revisione di 107 casi
Infectious mononucleosis: a review of 107 cases
Cecilia Geraci1, mauro Pocecco2
1Clinica Pediatrica, IRCCS Pediatrico Burlo Garofolo, Trieste
2UO di Pediatria, Ospedale Bufalini, Cesena
Ottobre 2012 - pagg. 521 -523
Abstract
Childhood infectious mononucleosis is a benign and self-limited disease. Complications
are rare but not unremarkable: 3 out of 107 patients experienced haematological complications
(1 autoimmune haemolytic anaemia and 2 autoimmune thrombocytopenia), 2 of
which required specific treatment (blood transfusion and IvIg respectively). Steroid treatment
was reserved to patients with respiratory obstruction or prolonged fever with poor
general condition and symptomatic effect was observed in all of the treated cases within
24 hours. The risk/benefit ratio of steroid treatment was justified by the brief period of
therapy (4 days) and the dose (1 mg/kg of prednisone or 0.1 mg/kg of betamethasone).
Parole chiave
Classificazione MeSH
Bibliografia
1. Kliegman R, Stanton B, St. Geme J, et al.
Nelson Textbook of Pediatrics, 19th Edition
2011.
2. Tanaka M, Kamijo T, Koike K, et al. Specific
autoantibodies to platelet glycoproteins in
Epstein-Barr virus-associated immune thrombocytopenia.
Int J Hematol 2003;78:168-
70.
3. Candy B, Hotopf M. Steroids for symptom
control in infectious mononucleosis. Cochrane
Database Syst Rev 2006;(3):CD004402.
4. Luzuriaga K, Sullivan JL. Infectious mononucleosis.
N Engl J Med 2010;362:1993-2000.
5. Collins M, Fleisher G, Kreisberg J, Fager
S. Role of steroids in the treatment of infectious
mononucleosis in the ambulatory college
student. J Am Coll Health 1984;33:101-5.
6. Thompson SK, Doerr TD, Hengerer AS.
Infectious mononucleosis and cor ticosteroids:
management practices and outcomes.
Arch Otolaryngol Head Neck Surg 2005;131:
900-4.
Corrispondenza: mpocecco@ausl-cesena.emr.it
