Problemi correnti
Il fruttosio prima del divezzamento: quali i motivi per evitarne l’assunzione?
Fructose before weaning: why avoid taking it?
Raffaele Iorio, Maria Giovanna Puoti, Fabrizia Chiatto, Giancarlo Parenti, Maria Immacolata Spagnuolo
Dipartimento di Scienze Mediche Traslazionali, Sezione di Pediatria, Università “Federico II”, Napoli
Maggio 2013 - pagg. 289 -294
Abstract
In the last few decades there has been a considerable increase in fructose and sweeteners
consumption. At the same time, there has been an increase in childhood obesity and an
ever more evident correlation between high fructose intake and obesity risk. Fructose, sucrose
and sorbitol are toxic sugars for patients with Hereditary Fructose Intolerance (HFI),
a rare disease in which early exposure to these carbohydrates can cause severe reactions,
which are potentially lethal. The promotion of “fructose-free” diet before weaning
could be a preventive measure for both childhood obesity and serious reactions due to
early exposure to fructose in infants with HFI. On the other hand, it is not documented that
an early introduction of fructose before weaning provides nutritional benefits for infants.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Contenuto riservato
Per leggere l'articolo completo è necessario effettuare il login.
Non sei ancora registrato? Registrati
Bibliografia
gh-
fructose syrup and crystalline fructose.
Am J Clin Nutr 1993;58:733S-736S.
2. Mayes PA. Intermediary metabolism of
fructose. Am J Clin Nutr 1993;58:754S-765S.
3. Bouteldja N, Timson DJ. The biochemical
basis of hereditary fructose intolerance. J
Inherit Metab Dis 2010;33:105-12.
4. Aller EE, Abete I, Astrup A, Martinez JA,
van Baak MA. Starches, sugars and obesity.
Nutrients 2011;3:341-69.
5. Tappy L, Lê KA. Metabolic effects of fructose
and the worldwide increase in obesity.
Physiol Rev 2010;90:23-46.
6. Hu FB, Malik VS. Sugar-sweetened beverages
and risk of obesity and type 2 diabetes:
epidemiologic evidence. Physiol Behav 2010;
100:47-54.
7. Malik VS, Popkin BM, Bray GA, Després
JP, Hu FB. Sugar sweetened beverages, obesity,
type 2 diabetes mellitus, and cardiovascular
disease risk. Circulation 2010;121:1356-
64.
8. Vos MB, Lavine JE. Dietary fructose in nonalcoholic
fatty liver disease. Hepatology 2013
Feb 6 [Epub ahead of print].
9. Pollock NK, Bundy V, Kanto W, et al. Greater
fructose consumption is associated with
cardiometabolic risk markers and visceral adiposity in adolescents. J Nutr 2012;142:251-7.
10. Maier IB, Stricker L, Ozel Y, Wagnerberger
S, Bischoff SC, Bergheim I. A low fructose
diet in the treatment of pediatric obesity: a pilot
study. Pediatr Int 2011;53:303-8.
11. World Health Organization. Global Data
Bank on Breastfeeding and Complementary
Feeding. Geneva, 1996 (WHO/NUT/96.1).
12. Section on Breastfeeding. Breastfeeding
and the use of human milk. Pediatrics 2012;
129:e827-41.
13. Koletzko B, Baker S, Cleghorn G, et al.
Global standard for the composition of infant
formula: recommendations of an ESPGHAN
coordinated international expert group. J Pediatr
Gastroenterol Nutr 2005;41:584-99.
14. Department of Nutrition for Health and
Development World Health Organization.
Complementary feeding. Family foods for
breasged children. World Health Organization,
2000.
15. Committee on Nutrition American Academy
of Pediatrics: The use and misuse of
fruit juice in pediatrics. Pediatrics 2001;107:
1210-3.
16. US Food and Drug Administration.
http://www.fda.gov/Food/ResourcesFor
You/HealthEducators/ucm089629.htm. Page
Last Updated: 10/25/2011.
17. Stettler N, Bhatia J, Parish A, Stallings VA.
Feeding healthy infants, children, and adolescents.
In: Kliegman RM, Behrman RE, Jenson
HB, Stanton BF. Nelson Textbook of Pediatrics.
19th ed. Philadelphia, Pa: Saunders
Elsevier, 2011: chap 42.
18. Marriott BP, Cole N, Lee E. National estimates
of dietary fructose intake increate from
1977 to 2004 in the United States. J Nutr 2009;
139:1228S-1235S.
19. Qi Q, Chu AY, Kang JH, et al. Sugar-sweetened
beverages and genetic risk of obesity. N
Engl J Med 2012;367:1387-96.
20. Aeberli I, Kaspar M, Zimmermann MB.
Dietary intake and physical activity of normal
weight and overweight 6 to 14 year old Swiss
children. Swiss Med Wkly 2007;137:424-30.
21. Maier IB, Stricker L, Ozel Y, Wagnerberger
S, Bischoff SC, Bergheim I. A low fructose
diet in the treatment of pediatric obesity: a pilot
study. Pediatr Int 2011;53:303-8.
22. McGuire S. Institute of Medicine (IOM)
Early Childhood Obesity Prevention Policies.
Washington, DC: The National Academies
Press; 2011. Adv Nutr 2012;3:56-7.
23. Thompson AL, Bentley ME. The critical
period of infant feeding for the development
of early disparities in obesity. Soc Sci Med
2012 Dec 17. pii: S0277-9536(12)00814-3. doi:
10.1016/j.socscimed.2012.12.007[Epub ahead
of print].
24. Greco L, Morini G. Lo sviluppo del gusto
nel bambino. Medico e Bambino 2010;29:509-
13.
25. Mennella JA, Jagnow CP, Beauchamp GK.
Prenatal and postnatal flavor learning by human
infants. Pediatrics 2001;107:E88.
26. Mennella JA, Lukasewycz LD, Castor SM,
Beauchamp GK. The timing and duration of a
sensitive period in human flavor learning: a
randomized trial. Am J Clin Nutr 2011;93:1019-
24.
27. Liem DG, Mennella JA. Sweet and sour
preferences during childhood: role of early experiences.
Dev Psychobiol 2002;41:388-95.
28. Froesch ER, Wolf HP, Bitsch H, Prader A,
Labhart A. Hereditary fructose intolerance:
an inborn defect of hepatic fructose-1-phosphate
splitting aldolase. Am J Med 1963;34:
151-67.
29. Santer R, Rischewski J, von Weihe M, et
al. The spectrum of aldolase B (ALDO B) mutations
and the prevalence of hereditary fructose
intolerance in Central Europe. Hum Mutat
2005;25:594.
30. Woods HF, Eggleston LV, Krebs H. The
cause of hepatic accumulation of fructose-1-
phosphate on fructose loading. Biochem J
1970;119:501-10
31. Ali M, Rellos P, Cox TM. Hereditary fructose
intolerance. J Med Genet 1998;35:353-65.
32. Odievre M, Gentil C, Gautier M, Alagille D.
Hereditary fructose intolerance in childhood:
diagnosis, management and course in 55 patients.
Am J Child 1978;132:605-8.
33. Mock DM, Perman JA, Thaler MM, Morris
RC Jr. Chronic fructose intoxication after
infancy in children with hereditary fructose
intolerance: a cause of growth retardation. N
Engl J Med 1983;309:764-70.
34. Chambers RA, Pratt RTC. Idiosyncrasy to
fructose. Lancet 1956;ii:340.
35. Baerlocher K, Gitzelmann R, Steinmann B,
Gitzelmann-Cumarasamy N. Hereditary fructose
intolerance in early childhood: a major
diagnostic challenge. Survey of 20 symptomatic
cases. Helv Paediatr Acta 1978;33:465-87.
36. Cornblath M, Rosenthal IM, Reisner SH,
Wybregt SH, Crane RK. Hereditary fructose
intolerance. N Engl J Med 1963;269:1271-8.
37. Oberhaensli RD, Rajagopalan B, Taylor
DJ, et al. Study of hereditary fructose intolerance
by use of (31)P magnetic resonance
spectroscopy. Lancet 1987;11:931-4.
38. Scriver CR, Beaudet AL, Sly WS, Valle D.
The Metabolic and Molecular Bases of Inherited
Disease, 8th ed. Part 4: Carbohydrates;
Chapter 23; Disorder of fructose metabolism.
New York: McGraw-Hill, 2001:914-20.
39. Ministero della Salute. Decreto 7 febbraio
2003. GU Serie Generale, n. 43 del 21 febbraio
2003.
40. Cox TM. Iatrogenic deaths in hereditary
fructose intolerance. Arch Dis Child 1993;69:
413-5.
41. Cox TM. The genetic consequences of our
sweet tooth. Nat Rev 2002;3:7-13.
42. EMEA, Reflection Paper: formulations of
choice for the paediatric population, 28 Luglio
2006. www.emea.europa.eu.
43. Harrison D, Beggs S, Stevens B. Sucrose
for procedural pain management in infants.
Pediatrics 2012;130:918-25.
Corrispondenza: riorio@unina.it
