Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Problemi correnti

Il fruttosio prima del divezzamento: quali i motivi per evitarne l’assunzione?

Fructose before weaning: why avoid taking it?

Raffaele Iorio, Maria Giovanna Puoti, Fabrizia Chiatto, Giancarlo Parenti, Maria Immacolata Spagnuolo

Dipartimento di Scienze Mediche Traslazionali, Sezione di Pediatria, Università “Federico II”, Napoli

Maggio 2013 - pagg. 289 -294

Abstract
In the last few decades there has been a considerable increase in fructose and sweeteners consumption. At the same time, there has been an increase in childhood obesity and an ever more evident correlation between high fructose intake and obesity risk. Fructose, sucrose and sorbitol are toxic sugars for patients with Hereditary Fructose Intolerance (HFI), a rare disease in which early exposure to these carbohydrates can cause severe reactions, which are potentially lethal. The promotion of “fructose-free” diet before weaning could be a preventive measure for both childhood obesity and serious reactions due to early exposure to fructose in infants with HFI. On the other hand, it is not documented that an early introduction of fructose before weaning provides nutritional benefits for infants.
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Bibliografia
gh- fructose syrup and crystalline fructose. Am J Clin Nutr 1993;58:733S-736S. 2. Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr 1993;58:754S-765S. 3. Bouteldja N, Timson DJ. The biochemical basis of hereditary fructose intolerance. J Inherit Metab Dis 2010;33:105-12. 4. Aller EE, Abete I, Astrup A, Martinez JA, van Baak MA. Starches, sugars and obesity. Nutrients 2011;3:341-69. 5. Tappy L, Lê KA. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 2010;90:23-46. 6. Hu FB, Malik VS. Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence. Physiol Behav 2010; 100:47-54. 7. Malik VS, Popkin BM, Bray GA, Després JP, Hu FB. Sugar sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation 2010;121:1356- 64. 8. Vos MB, Lavine JE. Dietary fructose in nonalcoholic fatty liver disease. Hepatology 2013 Feb 6 [Epub ahead of print]. 9. Pollock NK, Bundy V, Kanto W, et al. Greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescents. J Nutr 2012;142:251-7. 10. Maier IB, Stricker L, Ozel Y, Wagnerberger S, Bischoff SC, Bergheim I. A low fructose diet in the treatment of pediatric obesity: a pilot study. Pediatr Int 2011;53:303-8. 11. World Health Organization. Global Data Bank on Breastfeeding and Complementary Feeding. Geneva, 1996 (WHO/NUT/96.1). 12. Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics 2012; 129:e827-41. 13. Koletzko B, Baker S, Cleghorn G, et al. Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group. J Pediatr Gastroenterol Nutr 2005;41:584-99. 14. Department of Nutrition for Health and Development World Health Organization. Complementary feeding. Family foods for breasged children. World Health Organization, 2000. 15. Committee on Nutrition American Academy of Pediatrics: The use and misuse of fruit juice in pediatrics. Pediatrics 2001;107: 1210-3. 16. US Food and Drug Administration. http://www.fda.gov/Food/ResourcesFor You/HealthEducators/ucm089629.htm. Page Last Updated: 10/25/2011. 17. Stettler N, Bhatia J, Parish A, Stallings VA. Feeding healthy infants, children, and adolescents. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: Saunders Elsevier, 2011: chap 42. 18. Marriott BP, Cole N, Lee E. National estimates of dietary fructose intake increate from 1977 to 2004 in the United States. J Nutr 2009; 139:1228S-1235S. 19. Qi Q, Chu AY, Kang JH, et al. Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med 2012;367:1387-96. 20. Aeberli I, Kaspar M, Zimmermann MB. Dietary intake and physical activity of normal weight and overweight 6 to 14 year old Swiss children. Swiss Med Wkly 2007;137:424-30. 21. Maier IB, Stricker L, Ozel Y, Wagnerberger S, Bischoff SC, Bergheim I. A low fructose diet in the treatment of pediatric obesity: a pilot study. Pediatr Int 2011;53:303-8. 22. McGuire S. Institute of Medicine (IOM) Early Childhood Obesity Prevention Policies. Washington, DC: The National Academies Press; 2011. Adv Nutr 2012;3:56-7. 23. Thompson AL, Bentley ME. The critical period of infant feeding for the development of early disparities in obesity. Soc Sci Med 2012 Dec 17. pii: S0277-9536(12)00814-3. doi: 10.1016/j.socscimed.2012.12.007[Epub ahead of print]. 24. Greco L, Morini G. Lo sviluppo del gusto nel bambino. Medico e Bambino 2010;29:509- 13. 25. Mennella JA, Jagnow CP, Beauchamp GK. Prenatal and postnatal flavor learning by human infants. Pediatrics 2001;107:E88. 26. Mennella JA, Lukasewycz LD, Castor SM, Beauchamp GK. The timing and duration of a sensitive period in human flavor learning: a randomized trial. Am J Clin Nutr 2011;93:1019- 24. 27. Liem DG, Mennella JA. Sweet and sour preferences during childhood: role of early experiences. Dev Psychobiol 2002;41:388-95. 28. Froesch ER, Wolf HP, Bitsch H, Prader A, Labhart A. Hereditary fructose intolerance: an inborn defect of hepatic fructose-1-phosphate splitting aldolase. Am J Med 1963;34: 151-67. 29. Santer R, Rischewski J, von Weihe M, et al. The spectrum of aldolase B (ALDO B) mutations and the prevalence of hereditary fructose intolerance in Central Europe. Hum Mutat 2005;25:594. 30. Woods HF, Eggleston LV, Krebs H. The cause of hepatic accumulation of fructose-1- phosphate on fructose loading. Biochem J 1970;119:501-10 31. Ali M, Rellos P, Cox TM. Hereditary fructose intolerance. J Med Genet 1998;35:353-65. 32. Odievre M, Gentil C, Gautier M, Alagille D. Hereditary fructose intolerance in childhood: diagnosis, management and course in 55 patients. Am J Child 1978;132:605-8. 33. Mock DM, Perman JA, Thaler MM, Morris RC Jr. Chronic fructose intoxication after infancy in children with hereditary fructose intolerance: a cause of growth retardation. N Engl J Med 1983;309:764-70. 34. Chambers RA, Pratt RTC. Idiosyncrasy to fructose. Lancet 1956;ii:340. 35. Baerlocher K, Gitzelmann R, Steinmann B, Gitzelmann-Cumarasamy N. Hereditary fructose intolerance in early childhood: a major diagnostic challenge. Survey of 20 symptomatic cases. Helv Paediatr Acta 1978;33:465-87. 36. Cornblath M, Rosenthal IM, Reisner SH, Wybregt SH, Crane RK. Hereditary fructose intolerance. N Engl J Med 1963;269:1271-8. 37. Oberhaensli RD, Rajagopalan B, Taylor DJ, et al. Study of hereditary fructose intolerance by use of (31)P magnetic resonance spectroscopy. Lancet 1987;11:931-4. 38. Scriver CR, Beaudet AL, Sly WS, Valle D. The Metabolic and Molecular Bases of Inherited Disease, 8th ed. Part 4: Carbohydrates; Chapter 23; Disorder of fructose metabolism. New York: McGraw-Hill, 2001:914-20. 39. Ministero della Salute. Decreto 7 febbraio 2003. GU Serie Generale, n. 43 del 21 febbraio 2003. 40. Cox TM. Iatrogenic deaths in hereditary fructose intolerance. Arch Dis Child 1993;69: 413-5. 41. Cox TM. The genetic consequences of our sweet tooth. Nat Rev 2002;3:7-13. 42. EMEA, Reflection Paper: formulations of choice for the paediatric population, 28 Luglio 2006. www.emea.europa.eu. 43. Harrison D, Beggs S, Stevens B. Sucrose for procedural pain management in infants. Pediatrics 2012;130:918-25.

Corrispondenza: riorio@unina.it