Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Farmacoriflessioni

Il midazolam in soluzione transmucosa orale

Oromucosal midazolam

Federico Marchetti1, Giovanna Rametta2, Paolo Ricciardelli3

1UOC di Pediatria e Neonatologia, 2Servizio di Farmacia Ospedaliera, AUSL di Ravenna
3Neurologia Pediatrica, Ospedale di Faenza

Maggio 2013 - pagg. 313 -317

Abstract
Oromucosal midazolam (Buccolam) has been recently approved also in Italy for the treatment of paediatric patients (aged 3 months to <18 years) with Dravet and Panayiotopoulos syndrome and with previous acute, prolonged, convulsive seizures (> 5 minutes). Oromucosal midazolam was at least as effective as rectal diazepam in clinical trials in children with prolonged, acute, convulsive seizures and as effective as intravenous diazepam in the treatment of seizures and was generally well tolerated. It has several advantages over rectal diazepam, the previous gold standard of treatment, such as a more convenient and socially acceptable administration route.
Parole chiave
Clinical trials Convulsioni crisi convulsive Licensed use Midazolam oromucosal midazolam per via oromucosal Oromucosal midazolam Seizures studi clinici uso autorizzato
Suggerite dall'AI
Benzodiazepine Benzodiazepines Midazolam
Classificazione MeSH
Therapeutics Drug Therapy Drug Administration Routes Administration, Oral Administration, Buccal
Chemical Actions and Uses Pharmacologic Actions Therapeutic Uses Central Nervous System Agents Anticonvulsants (34)
Heterocyclic Compounds Heterocyclic Compounds, Fused-Ring Heterocyclic Compounds, 2-Ring Benzazepines Benzodiazepines Benzodiazepinones
Dravet Syndrome (4)
Heterocyclic Compounds Heterocyclic Compounds, Fused-Ring Heterocyclic Compounds, 2-Ring Benzazepines Benzodiazepines Midazolam (13)
Pathological Conditions, Signs and Symptoms Signs and Symptoms Neurologic Manifestations Seizures (76)
Pathological Conditions, Signs and Symptoms Signs and Symptoms Neurologic Manifestations Seizures Status Epilepticus (11)
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Convulsioni e gastroenterite: un caso che insegna
Del Bono C, Ciambrelli F, Rocca A, Pierantoni L, G · 2022
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Nisticò D, Marchetti F, Badina L, Barbi E, Cozzi G · 2023
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RI Pagine elettroniche
Un caso di convulsione protratta
R. Giorgi, A. Lorusso, Z. Cannioto, E. Barbi · 2005
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· 2026
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Bibliografia
1. Appleton R, Macleod S, Martland T. Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. Cochrane Database Syst Rev 2008;(3):CD001905. doi: 10.1002/14651858. CD001905.pub2. 2. McMullan J, Sasson C, Pancioli A, Silbergleit R. Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis. Acad Emerg Med 2010;17(6):575-82. 3. Bassan H, Barzilay M, Shinnar S, Shorer Z, Matoth I, Gross-Tsur V. Prolonged febrile seizures, clinical characteristics, and acute management. Epilepsia 2013 Apr 3. doi: 10.1111/ epi.12164 [Epub ahead of print]. 4. Capovilla G, Vecchi M, Beccaria F, Sartori S, Minicucci F, Vigevano F. Trattamento dello stato di male epilettico nel bambino. Raccomandazioni della Lega Italiana contro l’Epilessia. http://www.lice.it/pdf/sec_pediatrico. pdf. 5. Covanis A. Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis. Pediatrics 2006;118(4):e1237-43. 6. Lee D, Gladwell D, Batty AJ, Brereton N, Tate E. The Cost Effectiveness of Licensed Oromucosal midazolam (Buccolam) for the Treatment of Children Experiencing Acute Epileptic Seizures: An Approach When Trial Evidence is Limited. Paediatr Drugs 2013; 15(2):151-62. 7. Anderson M. Benzodiazepines for prolonged seizures. Arch Dis Child Educ Pract Ed 2010;95(6):183-9.

Corrispondenza: federico.marchetti@ausl.ra.it