Aggiornamento
Piastrine che scendono, piastrine che salgono: quando preoccuparsi?
Platelet count changes in children: how to manage?
Emilia Parodi1, Giulia Ansaldi2, Carlotta Botto2, Mirella Davitto2, Anna Mondino2, Cristina Olivieri2, Ugo Ramenghi2
1SC di Pediatria e Neonatologia, Ospedale Ordine Mauriziano, Torino
2Dipartimento di Scienze della Sanità Pubblica e Pediatriche, Università di Torino
Dicembre 2013 - pagg. 629 -634
Abstract
Thrombocytopenia and thrombocytosis are defined by a decreased or an elevated
platelet count, respectively. Changes in the platelet number are frequently observed during
childhood. This article aims at quickly examining the main causes of thrombocytopenia
and thrombocytosis in children in order to help the paediatricians with their diagnosis
and management.
Parole chiave
Classificazione MeSH
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Bibliografia
1. Kuhne T, Buchanan GR, Zimmerman S, et
al. A prospective comparative study of 2540 infants
and children with newly diagnosed idiopathic
thrombocytopenic purpura (ITP) from
the Intercontinental Childhood ITP Study
Group. J Pediatr 2003;143:605-8.
2. Kühne T, Berchtold W, Michaels LA, et al.
Newly diagnosed immune thrombocytopenia
in children and adults: a comparative prospective
observational registry of the Intercontinental
Cooperative Immune Thrombocytopenia
Study Group. Haematologica 2011;96:
1831-7.
3. Guidelines for the investigation and management
of idiopathic thrombocytopenic purpura
in adults, children and in pregnancy. Br J
Haematol 2003;120:574-96.
4. De Mattia D, Del Principe D, Del Vecchio
GC, et al. Acute childhood idiopathic thrombocytopenic
purpura: AIEOP consensus
guidelines for diagnosis and treatment. Associazione
Italiana di Ematologia e Oncologia
Pediatrica. Haematologica 2000;85:420-4.
5. Neunert C, Lim W, Crowther M, Cohen A,
Solberg L Jr, Crowther MA. The American Society
of Hematology 2011 evidence-based
practice guideline for immune thrombocytopenia.
Blood 2011;117:4190-207.
6. Balduini CL, Pecci A, Noris P. Diagnosis and
management of inherited thrombocytopenias.
Semin Thromb Hemost 2013;39:161-71.
7. Balduini CL, Cattaneo M, Fabris F, et al. Inherited
thrombocytopenias: a proposed diagnostic
algorithm from the Italian Gruppo di
Studio delle Piastrine. Haematologica 2003;
88:582-92.
8. Sutor AH. Thrombocytosis. In: Lilleyman
JS, Hann IM, Blanchette VS (Eds). Pediatric
Hematology. London, Edinburgh, New York,
Philadelphia, Sydney, Toronto: Churchill Livingstone,
1999:455-64.
9. Dame C, Sutor AH. Primary and secondary
thrombocytosis in childhood. Br J Haematol
2005;129:165-77.
10. Ishiguro A, Suzuki Y, Mito M, et al. Elevation
of serum thrombopoietin precedes
thrombocytosis in acute infections. Br J
Haematol 2002;116:612-8.
11. Dan K. Thrombocytosis in iron deficiency
anemia. Intern Med 2005;44:1025-6.
12. Putti MC, Giona F, Consarino C, et al. Retrospective
evaluation of 90 children with essential
thrombocytemia: The AIEOP Experience.
ASH Annual Meeting Abstracts 2008;
112:664.
13. Hasle H. Incidence of essential thrombocythaemia
in children. Br J Haematol 2000;
110:751.
14. Fu R, Zhang L, Yang R. Paediatric essential
thrombocythaemia: clinical and molecular features,
diagnosis and treatment. Br J Haematol
2013;163:295-302.
15. Giona F, Teofili L, Moleti ML, et al. Thrombocythemia
and polycythemia in patients
younger than 20 years at diagnosis: clinical
and biologic features, treatment, and longterm
outcome. Blood 2012;119:2219-27.
Corrispondenza: ugo.ramenghi@unito.it
