Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
Login Abbonamenti Pubblicazioni Carrello Registrazione Perché registrarsi? Contatti

Farmacoriflessioni

Tosse acuta e miele

Acute cough and honey

Stefano Miceli Sopo1, Serena Monaco1, Monica Greco1, Giuseppe Varrasi2, Giovanni Simeone3 per il Milk and Honey Study (M&HS) Group

1Clinica Pediatrica, Policlinico A. Gemelli, Universitŕ Cattolica del Sacro Cuore, Roma; 2Direttore di Pediatria on line, Brescia; 3Pediatra di famiglia, Carovigno (Brindisi)

Gennaio 2014 - pagg. 41 -46

Abstract
Recent Australian guidelines on cough in children recommend the use of honey as cough suppressant. Conversely, the same guidelines, just like other documents previously published, advise against the use of drugs like antitussives, such as codeine and dextrometrophan, because of the lack of demonstration of their efficacy and because of their possible serious side effects. Moreover, even for honey, available revisions on its use in acute nonspecific cough are not so much in favour. So, it becomes necessary for the paediatrician to review the scientific evidence in order to come up with his own informed opinion and be able to express it. The solution is not as clear as many people would like to, but eventually, it will probably make it possible for the paediatrician to take a definite position.
Contenuto riservato

Per leggere l'articolo completo è necessario effettuare il login.

Non sei ancora registrato? Registrati

Bibliografia
1. American Academy of Pediatrics. Use of codeine - and dextromethorphan - containing cough remedies in children. Committee on Drugs. Pediatrics 1997;99:918-20. 2. Smith SM, Schroeder K, Fahey T. Overthe- counter (OTC) medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev 2012; 8:CD001831. 3. Kelly LE, Rieder M, van den Anker J, et al. More codeine fatalities after tonsillectomy in North American children. Pediatrics 2012; 129: e1343-7. 4. Gibson PG, Chang AB, Glasgow NJ. CICADA: Cough in Children and Adults: Diagnosis and Assessment. Australian cough guidelines summary statement. Med J Aust 2010; 192:265-71. 5. Oduwole O, Meremikwu MM, Oyo-Ita A. Honey for acute cough in children. Cochrane Database Syst Rev 2012;3:CD007094. 6. Paul IM, Beiler J, McMonagle A, et al. Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Arch Pediatr Adolesc Med 2007;161: 1140-6. 7. Shadkam MN, Mozaf fari-Khosravi H, Mozayan MR. A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. J Altern Complement Med 2010;16:787-93. 8. Cohen HA, Rozen J, Kristal H, et al. Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study. Pediatrics 2012;130:465-71. 9. Guyatt GH, Sackett DL, Cook DJ, for the Evidence-Based Medicine Working Group. Users’ guides to the medical literature, II: how to use an article about therapy or prevention, A: Are the results of the study valid? JAMA 1993;270:2598-601. 10. Paul IM, Yoder KE, Crowell KR, et al. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 2004;114:e85-90. 11. Walburn J. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 2004;114: 1370. 12. Eccles R. Mechanisms of the placebo effect of sweet cough syrups. Respir Physiol Neurobiol 2006;152:340-8. 13. Axelsson I. Honey, not dextromethorphan, was better than no treatment for nocturnal cough in children with upper respiratory infections. Evid Based Med 2008;13:106. 14. Warren MD, Pont SJ, Barkin SL, et al. The effect of honey on nocturnal cough and sleep quality for children and their parents. Arch Pediatr Adolesc Med 2007;161:1149-53. 15. Maddocks SE, Lopez MS, Rowlands RS, et al. Manuka honey inhibits the development of Streptococcus pyogenes biofilms and causes reduced expression of two fibronectin binding proteins. Microbiology 2012;158:781- 90. 16. Ashkin E, Mounsey A. PURLs: a spoonful of honey helps a coughing child sleep. J Fam Pract 2013;62:45-7. 17. Hróbjar tsson A, Gřtzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001;344:1594-602. 18. Howick J, Friedemann C, Tsakok M, et al. Are treatments more effective than placebos? A systematic review and meta-analysis. PLoS One 2013;8:e62599. 19. Bailar JC 3rd. The powerful placebo and the Wizard of Oz. N Engl J Med 2001;344: 1630-2. 20. Fuiano N, Incorvaia C, Riario-Sforza GG, et al. Anaphylaxis to honey in pollinosis to mugwort: a case report. Eur Ann Allergy Clin Immunol 2006;38:364-5. 21. White JW. Composition of honey. In: Crabe E (Ed). Honey: A Comprehensive Survey. New York, NY: Crane, Russak Company, 1975:157-206. 22. Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J Agric Food Chem 2002;50:3050-5.

Corrispondenza: smicelisopo@rm.unicatt.it