L'esperienza che insegna
La linfadenite di Kikuchi-Fujimoto
Kikuchi-Fujimoto disease
Vanna Graziani1, Vladimiro Armaroli2, Loredana Cardinale3, Franca Ravaioli4, Federico Marchetti1
1UOC di Pediatria e Neonatologia, 2UO di Otorinolaringoiatria, 3UO di Anatomia Patologica, Ospedale di Ravenna, AUSL della Romagna
4Pediatra di libera scelta, Ravenna, AUSL della Romagna
Giugno 2015 - pagg. 382 -385
Abstract
Kikuchi-Fujimoto disease (KF), also known as histiocytic necrotizing lymphadenitis, is a
rare benign condition characterized by cervical lymphadenopathy, prolonged fever and
other systemic manifestations without specific laboratory findings. The etiology is unknown
but an exaggerated immune response to an autoimmune or viral trigger is hypothesized.
It can mimic malignancies such as lymphoma; the diagnosis is based on the
histological examination of a lymph node biopsy. There is no specific treatment for KF,
but symptomatic therapy is indicated. In severe cases corticosteroids or other immunomodulating
agents have been used. Recurrences are possible and a risk of development
of autoimmune disorders (primarily SLE) is described. The paper reports the unusual
case of an 8-year-old Caucasian girl with relapsing KF (3 episodes) that presented
with cervical and supraclavicular lymphadenopathy. The importance of a correct diagnosis
and long-term follow-up is emphasized.
Classificazione MeSH
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Corrispondenza: vanna.graziani@gmail.com