Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Chetoacidosi secondaria a tireotossicosi in ragazza con diabete tipo 1 e celiachia

Type 1 diabetes mellitus and coeliac disease with secondary ketoacidosis triggered by thyrotoxicosis: a case report

Vanna Graziani1, Andrea Zucchini2, Tosca Suprani3, Francesca Curṛ1, Lorenzo Mambelli1, Federico Marchetti1

1UOC di Pediatria e Neonatologia, Ospedale di Ravenna; 2Ospedale di Faenza; 3UOC di Pediatria e Neonatologia, Ospedale di Cesena, AUSL della Romagna

Marzo 2016 - pagg. 191 -194

Abstract
The paper describes the case of a teenager affected by type 1 diabetes mellitus and coeliac disease who presented secondary ketoacidosis (DKA) triggered by thyrotoxicosis. She was successfully treated with beta-blocker and methimazole, in addition to intravenous insulin therapy. The association of thyrotoxicosis and DKA is uncommon but anecdotal cases are reported in literature. Through different mechanisms hyperthyroidism may cause decreased levels of insulin and increased glycogenolysis, ketogenesis, dehydration, and insulin resistance. The possibility of DKA triggered by thyrotoxicosis should be kept in mind in female patient or in the presence of symptoms of hyperthyroidism.
Parole chiave
Coeliac disease Diabetes Ketoacidosis Thyrotoxicosis
Suggerite dall'AI
celiac disease celiachia diabete tipo 1 hyperthyroidism ipertiroidismo type 1 diabetes
Classificazione MeSH
Chemical Actions and Uses Pharmacologic Actions Molecular Mechanisms of Pharmacological Action Neurotransmitter Agents Adrenergic Agents Adrenergic Antagonists
Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Malabsorption Syndromes Celiac Disease (221)
Nutritional and Metabolic Diseases Metabolic Diseases Glucose Metabolism Disorders Diabetes Mellitus Diabetes Mellitus, Type 1 (101)
Nutritional and Metabolic Diseases Metabolic Diseases Acid-Base Imbalance Acidosis Ketosis Diabetic Ketoacidosis (20)
Endocrine System Diseases Thyroid Diseases Hyperthyroidism (9)
Hormones, Hormone Substitutes, and Hormone Antagonists Hormones Peptide Hormones Pancreatic Hormones Insulins Proinsulin
Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Azoles Imidazoles Methimazole (6)
Endocrine System Diseases Thyroid Diseases Hyperthyroidism Thyrotoxicosis (2)
Leggi anche
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V. Graziani, A. Zucchini, T. Suprani, F. Curṛ, L. · 2016
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Corrispondenza: vanna.graziani@gmail.com