Percorsi clinici
La diagnosi differenziale delle malattie che si presentano con IgE alte
Differential diagnosis of disease with elevated IgE levels
Gloria Patelli, Sara Farimbella, Manuela Cortesi, Raffaele Badolato
Clinica Pediatrica, Universitΰ di Brescia
Gennaio 2017 - pagg. 39 -43
Abstract
Elevated IgE levels (higher than 1500 UI) can be detected in multiple conditions observed
in childhood, including atopic dermatitis, infectious diseases or primary immunodeficiencies.
This article describes the case of a child who in the first year of life presented with
pustulosis, failure to thrive, high IgE levels and eosinophilia. Immunological and genetic
studies revealed that he was affected by hyper IgE syndrome, also known as Job syndrome.
This is a genetic disorder that is inherited as autosomal dominant trait that shares
many signs and symptoms with atopic dermatitis, as well as with several primary immunodeficiencies,
such as IPEX, combined immunodeficiencies and Netherton syndrome.
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Bibliografia
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Corrispondenza: raffaele.badolato@unibs.it
