Percorsi clinici
Due casi di favismo: dalla diagnosi alla gestione
Two cases of favism: from diagnosis to management
Claudia Guiducci*, Adriana Fumarola*, Sara Pusceddu, Caterina Radice, Federico Marchetti
UOC di Pediatria e Neonatologia, Ospedale di Ravenna, AUSL della Romagna
*Scuola di Specializzazione in Pediatria, Università di Ferrara
Giugno 2018 - pagg. 379 -383
Abstract
Glucose-6-phosphate dehydrogenase deficiency (G6PD) is the most common red blood cells
enzymopathy that affects 400 million people worldwide and is especially prevalent in areas
of high malaria infection. G6PD deficiency has an X-linked recessive mode of inheritance
and most known mutations in the G6PD gene decrease the enzyme stability. Oxidative stress,
e.g. ingestion of fava beans, can induce acute haemolytic anaemia in affected individuals.
The paper describes the case of two 6-month and 5-year-old male children with an acute
haemolytic crisis due to the ingestion of fava beans. Due to increased immigration, the condition
is expected to occur more often in Italian healthcare centres.
Parole chiave
Classificazione MeSH
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Corrispondenza: federico.marchetti@auslromagna.it