Problemi speciali
Sindrome TINU: dall’occhio al rene andata e ritorno
TINU Syndrome: round trip from the eye to the kidney
Luisa Cortellazzo Wiel1, Giulia Gortani2, Serena Pastore2, Stefano Pensiero2, Marco Pennesi2, Antonio Filpo3, Enrico Valletta4, Alessandro Ventura1
1Università di Trieste
2IRCCS Materno-Infantile “Burlo Garofolo”, Trieste
3UO di Pediatria, Ospedale “L. Curto”, Polla, ASL di Salerno
4UO di Pediatria, Ospedale “G.B. Morgagni - L. Pierantoni”, Forlì, AUSL della Romagna
Febbraio 2019 - pagg. 103 -107
Abstract
TINU stands for TubuloInterstitial Nephritis and Uveitis syndrome. The effective incidence
of the disease is unknown, but it probably still remains largely underestimated. This can
be explained by the frequent existence of a time-gap between the occurrence of the two
conditions. In addition while uveitis is generally symptomatic with the classical clinical
presentation of red and painful bilateral eyes, nephritis is often silent. As to their evolution
the nephritic involvement tends to be self-limiting, while uveitis can progress to permanent
eye damage and requires the use of topic and systemic corticosteroids and
sometimes immunosuppressant drugs. It is advised to perform a simple urine stix in all
new cases of uveitis and to repeat it during the follow-up of apparently idiopathic
uveitis. On the other hand it is important to seek an ophtalmological evaluation in all the
cases of unexplained tubulointerstitial nephritis to rule out the presence of a silent uveitis.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Contenuto riservato
Per leggere l'articolo completo è necessario effettuare il login.
Non sei ancora registrato? Registrati
Bibliografia
1. Filpo A. Ancora il ribollir del TINU. Medico
e Bambino pagine elettroniche 2016;19(8).
2. Paladini A, Venturoli V, Fornaro M, La
Fauci G, Valletta E. Febbri di una notte di
mezza estate. Medico e Bambino pagine elettroniche
2014;17(2).
3. Howarth L, Gilbert RD, Bass P, Deshpande
PV. Tubulointerstitial nephritis and uveitis
in monozygotic twin boys. Pediatr Nephrol
2004;19(8):917-9.
4. Dusek J, Urbanova I, Stejskal J, Seeman T,
Vondrak K, Janda J. Tubulointerstitial nephritis
and uveitis syndrome in a mother and
her son. Pediatr Nephrol 2008;23(11):2091-3.
5. Levinson RD, Park MS, Rikkers SM, et al.
Strong associations between specific HLADQ
and HLA-DR allelles and the tubulointerstitial
nephritis and uveitis syndrome. Invest
Ophthalmol Vis Sci 2003;44(2):653-7.
6. Mackensen F, David F, Schwenger V, et
al. HLA-DRB1*0102 is associated with TINU
syndrome and bilateral, sudden-onset anterior
uveitis but not with interstitial nephritis
alone. Br J Ophthalmol 2011;95(7):971-5.
7. Tan Y, Yu F, Qu Z, et al. Modified C-reactive
protein might be a target autoantigen of
TINU syndrome. Clin J Am Soc Nephrol
2011;6(1):93-100.
8. Lee JW, Kim HJ, Sung SH, Lee SJ. A case
of tubulointerstitial nephritis and uveitis syndrome
with severe immunologic dysregulation.
Pediatr Nephrol 2005;20(12):1805-8.
9. Onyekpe I, Shenoy M, Denley H, Riad
H, Webb NJ. Recurrent tubulointerstitial
nephritis and uveitis syndrome in a renal
transplant recipient. Nephrol Dial Transplant
2011;26(9):3060-2.
10. Clive DM, Vanguri VK. The syndrome of
Tubulointerstitial Nephritis with Uveitis (TINU).
Am J Kidney Dis 2018;72(1):118-28.
11. Dobrin RS, Vernier RL, Fish AJ. Acute eosinophilic
interstitial nephritis and renal failure
with bone marrow-lymphnode granulomas
and anterior uveitis. Am J Med 1975;59(3):
325-33.
12. Mandeville JT, Levinson RD, Holland
GN. The tubulointerstitial nephritis and uveitis
syndrome. Surv Ophthalmol 2001;46(3):
195-208.
13. Vohra S, Eddy A, Levin AV, Taylor
G, Laxer RM. Tubulointerstitial nephritis and
uveitis in children and adolescents. Four new
cases and a review of the literature. Pediatr
Nephrol 1999;13(5):426-32.
14. Igarashi T, Kawato H, Kamoshita S, Nosaka
K, Seiya K, Hayakawa H. Acute tubulointerstitial
nephritis with uveitis syndrome
presenting as multiple tubular dysfunction including
Fanconi’s syndrome. Pediatr Nephrol
1992;6(6):547-9.
15. Kobayashi Y, Honda M, Yoshikawa N, Ito
H. Acute tubulointerstitial nephritis in 21 Japanese
children. Clin Nephrol 2000;54(3): 191-7.
16. Rømer FK. Angiotensin-converting enzyme
in sarcoidosis. Acta Med Scand 1979;206
(1-2):27-30.
17. Iannuzzi MC, Rybicki BA, Teirstein AS.
Sarcoidosis. N Engl J Med. 2007;357(21):
2153-65.
18. Kondo S, Kagami S, Shimizu M, et al.
The role of mast cells in acute tubulo-interstitial
nephritis with uveitis. Eur J Pediatr 2003;
162(7-8):496-9.
19. Tanaka H, Suzuki K, Nakahata T, Tateyama
T, Waga S, Ito E. Repeat renal biopsy in a
girl with tubulointerstitial nephritis and uveitis
syndrome. Pediatr Nephrol 2001;16(11):
885-7.
20. Mackensen F, Billing H. Tubulointerstitial
nephritis and uveitis syndrome. Curr
Opin Ophthalmol 2009;20(6):525-31.
21. Hettinga YM, Scheerlinck LM, Lilien
MR, Rothova A, de Boer JH. TThe value of
measuring urinary β2-microglobulin and serum
creatinine for detecting tubulointerstitial
nephritis and uveitis syndrome in young patients
with uveitis. JAMA Ophthalmol 2015;
133(2):140-5.
22. Suzuki K, Tanaka H, Ito E, Waga S. Repeat
renal biopsy in children with severe idiopathic
tubulointerstitial nephritis. Pediatr
Nephrol 2004;19(2):240-3.
Corrispondenza: cortellazzo_w@hotmail.it