Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Neonatologia

Osservazione nel neonato a rischio di sepsi precoce

Observation on the newborn at risk of early-onset sepsis: the approach of the Emilia-Romagna Region (Italy)

Alberto Berardi1, Caterina Spada2, Matilde Ciccia3, Mariagrazia Capretti4, Giacomo Brusa5, Fabrizio Sandri3, Eleonora Balestri6, Laura Rocca2, Lucia Gambini7, Milena Azzalli8, Vittoria Rizzo9, Giancarlo Piccinini10, Eleonora Vaccina2, Laura Lucaccioni1

1Terapia Intensiva Neonatale (TIN), Azienda Policlinico, Modena; 2Scuola di Specializzazione in Pediatria, Università di Modena e Reggio Emilia; 3TIN, Ospedale Maggiore, Bologna; 4TIN, Azienda Policlinico Sant’Orsola - Malpighi, Bologna; 5TIN, Ospedale Infermi, Rimini; 6TIN, Arcispedale Santa Maria Nuova, Reggio Emilia; 7TIN, Azienda Policlinico, Parma; 8TIN, Arcispedale Sant’Anna, Ferrara; 9TIN, Ospedale Bufalini, Cesena; 10TIN, Ospedale Santa Maria Delle Croci, Ravenna

Giugno 2019 - pagg. 370 -376

Abstract
The approach to the newborn at risk of early-onset sepsis is a challenge. In the past the approach was mainly based on laboratory tests, which were poorly predictive and might cause repeated blood samples and unnecessary antibiotic therapies, with possible long-term side effects. The medicalisation of asymptomatic newborns also interferes with breastfeeding. Recent experiences carried out in the Friuli Venezia Giulia and Emilia-Romagna Regions (Italy) have suggested that a less invasive approach is useful. This approach is mainly based on careful and repeated clinical observations of asymptomatic full-term or late preterm infants at standard intervals, regardless of risk factors. Moreover, it is useful for a timely diagnosis, does not separate mothers from their neonates and consequently does not interfere with the development of the nascent intestinal microbiota and breastfeeding.
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Bibliografia
1. Schrag SJ, Farley MM, Petit S, et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics 2016;138(6): e20162013. 2. Berardi A, Baroni L, Bacchi Reggiani ML, et al.; GBS Prevention Working Group Emilia- Romagna. The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population- based study. J Matern Fetal Neonatal Med 2016;29(19):3126-31. 3. Centers for Disease Control and Prevention. Active Bacterial Core surveillance (ABCs) Report Emerging Infections Program Network Group B Streptococcus. 2014. 4. Berardi A, Lugli L, Rossi C, et al; GBS Prevention Working Group, Emilia-Romagna. Impact of perinatal practices for early-onset group B Streptococcal disease prevention. Pediatr Infect Dis J 2013;32:e265-71. 5. Puopolo KM, Benitz WE, Zaoutis TE; AAP Committee on Fetus and Newborn; AAP Committee on Infectious Diseases. Management of neonates born at ≤ 34 6/7 weeks’ gestation with suspected or proven early-onset bacterial sepsis. Pediatrics 2018;142:e2018-96. 6. Puopolo KM, Benitz WE, Zaoutis TE; AAP Committee on Fetus and Newborn; AAP Committee on Infectious Diseases. Management of neonates born at ≥ 35 0/7 weeks’ gestation with suspected or proven early-onset bacterial sepsis. Pediatrics 2018;142:e2018-94. 7. Benitz WE. Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clin Perinatol 2010;37(2):421-38. 8. Benitz WE, Wynn JL, Polin RA. Reappraisal of guidelines for management of neonates with suspected early-onset sepsis. J Pediatr 2015;166(4):1070-4. 9. Verani JR, McGee L, Schrag SJ. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centres for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease-revised guidelines from CDC, 2010. MMWR Recomm Rep 2010;59(RR-10):1-36. 10. Hooven TA, Randis TM, Polin RA. What’s the harm? Risks and benefits of evolving rule- out sepsis practices. J Perinatol 2018;38 (6):614-22. 11. van Herk W, Stocker M, van Rossum AM. Recognising early onset neonatal sepsis: an essential step in appropriate antimicrobial use. J Infect 2016;72 Suppl:S77-82. 12. Ficara M, Pietrella E, Spada C, et al. Changes of intestinal microbiota in early life. J Matern Fetal Neonatal Med 2018, Sep 10:1- 8 [Epub ahead of print]. 13. Corvaglia L, Tonti G, Martini S, et al. Influence of intrapartum antibiotic prophylaxis for group B Streptococcus on gut microbiota in the first month of life. J Pediatr Gastroenterol Nutr 2016;62(2):304-8. 14. Randis TM, Polin RA, Saade G. Chorioamnionitis: time for a new approach. Curr Opin Pediatr 2017;29(2):159-64. 15. Cantoni L, Ronfani L, Da Riol R, Demarini S; Perinatal Study Group of the Region Friuli Venezia Giulia. Physical examination instead of laboratory tests for most infants born to mothers colonized with group B streptococcus: support for the Centers for Disease Control and Prevention’s 2010 recommendations. J Pediatr 2013;163(2):568-73. 16. Berardi A, Buffagni AM, Rossi C, et al. Serial physical examinations, a simple and reliable tool for managing neonates at risk for early-onset sepsis. World J Clin Pediatr 2016;5(4):358-64. 17. Berardi A, Fornaciari S, Rossi C, et al. Safety of physical examination alone for managing well-appearing neonates ≥ 35 weeks’ gestation at risk for early-onset sepsis. J Matern Fetal Neonatal Med 2015;28(10):1123-7. 18. Illuzzi JL, Bracken MB. Duration of intrapartum prophylaxis for neonatal group B streptococcal disease: a systematic review. Obstet Gynecol 2006;108(5):1254-65. 19. Bloom SL, Cox SM, Bawdon RE, Gilstrap LC. Ampicillin for neonatal group B streptococcal prophylaxis: how rapidly can bactericidal concentrations be achieved? Am J Obstet Gynecol 1996;175(4 Pt 1):974-6. 20. Barber EL, Zhao G, Buhimschi IA, Illuzzi JL. Duration of intrapartum prophylaxis and concentration of penicillin G in fetal serum at delivery. Obstet Gynecol 2008;112(2 Pt 1):265-70. 21. Berardi A, Rossi C, Biasini A, et al. Efficacy of intrapartum chemoprophylaxis less than 4 hours duration. J Matern Fetal Neonatal Med 2011;24(4):619-25. 22. Berardi A, Pietrangiolillo Z, Bacchi Reggiani ML, et al. Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates. Arch Dis Child Fetal Neonatal Ed 2018; 103(2):F152-6. 23. Fairlie T, Zell ER, Schrag S. Effectiveness of intrapartum antibiotic prophylaxis for prevention of early-onset group B streptococcal disease. Obstet Gynecol 2013;121(3):570-7. 24. Committee on Obstetric Practice. Committee Opinion No. 712: Intrapartum Management of Intraamniotic Infection. Obstet Gynecol 2017;130(2):e95-e101. 25. Kuzniewicz MW, Puopolo KM, Fischer A, et al. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr 2017;171(4):365-71. 26. Berardi A, Guidotti I, Vellani G, et al. La gestione del nato a rischio di infezione precoce. Medico e Bambino 2013;32(8):507-13. 27. Berardi A, Lugli L, Rossi C, et al. Neonatal bacterial meningitis. Minerva Pediatr 2010;62(3 Suppl 1):51-4. 28. Berardi A, Cattelani C, Creti R, et al. Group B streptococcal infections in the newborn infant and the potential value of maternal vaccination. Expert Rev Anti Infect Ther 2015;13(11):1387-99. 29. Berardi A, Ficara M, Pietrella E. Stewardship antimicrobica nel neonato e nel piccolo lattante. Perché e come praticarla. Medico e Bambino 2017;36(8):493-501.

Corrispondenza: aberardi@unimore.it