Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Prima la piastrinopenia poi l’embolia polmonare

Thrombocytopoenia followed by pulmonary embolism

Federico Marchetti, Caterina Radice, Loretta Biserna, Anna Chiara Nuzzo*, Lorenzo Mambelli

UOC di Pediatria e Neonatologia, *UOC di Cardiologia, Ospedale di Ravenna,
AUSL della Romagna

Dicembre 2019 - pagg. 631 -633

Abstract
The paper describes the case of a 17-year-old girl presenting with an initial diagnosis of severe idiopathic thrombocytopoenic purpura with negative ANA and positive Coombs test. After a first phase characterised by thrombocytopeonia with haemorrhagic manifestations, she developed a thrombotic event (pulmonary embolism) with a normal number of platelets, positive LAC, and anti-cardiolipin and anti-beta2-glycoprotein antibodies. Eventually, an anti-phospholipid antibody syndrome was diagnosed. The described case shows the complexity of a disease that resembles systemic lupus erythematosus but does not have the criteria to be diagnosed as such.
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Bibliografia

di riferimento • Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/ American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis 2019;78:1151-9. • Petri M, Orbai A-M, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012;64(8):2677-86. • Vadgama TS, Smith A, Bertolaccini ML. Treatment in thrombotic antiphospholipid syndrome: a review. Lupus 201928(10):1181- 8. • Wincup C, Ioannou Y. The differences between childhood and adult onset antiphospholipid syndrome. Front Pediatr 2018;6: 362.

Corrispondenza: federico.marchetti@auslromagna.it