Problemi speciali
SARS-CoV-2: quali implicazioni nella popolazione pediatrica
SARS-CoV-2: its implications in the paediatric population
Vania Giacomet 1, Marta Stracuzzi1, Valeria Rubinacci1, Gian Vincenzo Zuccotti2
1US di Infettivologia Pediatrica, Ospedale “Luigi Sacco”, 2Clinica Pediatrica, Ospedale dei Bambini “Vittore Buzzi”,
ASST “Fatebenefratelli Sacco”, Università di Milano
Febbraio 2020 - pagg. 93 -96
Abstract
By the end of December 2019 there was an outbreak of polmonitis of a new coronavirus
named SARS-CoV-2. Until now there have been 76,727 cases, 2,247 deaths and
18,562 healed patients in China and less than 1,200 cases in the rest of the world.
Few data are available regarding the epidemiology and the clinical manifestations in
the paediatric population, nonetheless the virus seems to be affecting this population
way less severely than the adults. This data may be due to an understatement of children’s
involvement, since they seem to have very scarce symptoms. The question that
arises is: can those mildly symptomatic or asymptomatic paediatric cases infect others
therefore enhancing the virus transmission?
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
1. Centre for Health Protection of the Hong
Kong Special Administrative Region Government.
CHP provides further information on
cluster of pneumonia cases in Wuhan. 12
gennaio 2020. https://www.info.gov.hk/gia/
general/202001/12/P2020011200710.htm.
2. Wang C, Horby PW, Hayden FG, Gao GF.
A novel coronavirus outbreak of global health
concern. Lancet 2020;395(10223):470-3.
3. Chan JFW, Yuan S, Kok KH, et al. A familial
cluster of pneumonia associated with the
2019 novel coronavirus indicating person-toperson
transmission: a study of a family cluster.
Lancet 2020;395(10223):514-23.
4. WHO. Coronavirus disease 2019 (COVID-
19) situation reports. https://www.who.int/
emergencies/diseases/novel-coronavirus-
2019/situation-reports. Ultimo accesso: 17
febbraio 2020.
5. Dong E, Du H, Gardner L. An interactive
web-based dashboard to track COVID-19 in
real time. Lancet Infectious Diseases. Disponibile
online, 19 febbraio 2020.
6. Cui J, Li F, Shi ZL. Origin and evolution of
pathogenic coronaviruses. Nat Rev Microbiol
2019;17(3):181-92.
7. Lu R, Zhao X, Li J, et al. Genomic characterisation
and epidemiology of 2019 novel coronavirus:
implications for virus origins and receptor
binding. 2020;395(10224):565-74.
8. WHO. Managing epidemics. Key facts
about major deadly diseases. 2018. https://
www.who.int/emergencies/diseases/managing-
epidemics-interactive.pdf.
9. Kampf G, Todt D, Pfaender S, Steinmann
E. Persistence of coronaviruses on inanimate
surfaces and its inactivation with biocidal
agents. J Hosp Infect 2020 Feb 6 [Epub
ahead of print].
10. Sun K, Chen J, Viboud C. Early epidemiological
analysis of the coronavirus disease
2019 outbreak based on crowd sourced data:
a population level observational study. Lancet,
pubblicato online 20 febbraio 2020.
11. Ge XY, Li JL, Yang XL, et al. Isolation and
characterization of a bat SARS-like coronavirus
that uses the ACE2 receptor. Nature
2013;503(7477):535-8.
12. Wang M, Cao R, Zhang L, et al. Remdesivir
and chloroquine effectively inhibit the recently
emerged novel coronavirus (2019-
nCoV) in vitro. Cell Res 2020 Feb 4 [Epub
ahead of print].
13. Lim J, Jeon S, Shin HY, et al. Case of the
index patient who caused tertiary transmission
of coronavirus disease 2019 in Korea:
the application of lopinavir/ritonavir for the
treatment of COVID-19 pneumonia monitored
by quantitative rt-PCR. J Korean Med Sci
2020;35(6):e79.
14. Zhang L, Liu Y. Potential interventions
for novel coronavirus in China: a systemic review.
J Med Virol 2020 Feb 13 [Epub ahead
of print].
15. The Novel Coronavirus Pneumonia
Emergency Response Epidemiology Team.
The epidemiological characteristics of an
outbreak of 2019 novel coronavirus diseases
(COVID-19). China CDC Weekly 2020;2(8):
113-22.
16. Wang XF, Yuan J, Zheng YJ, et al. Clinical
and epidemiological characteristics of 34
children with 2019 novel coronavirus infection
in Shenzhen. Zhonghua Er Ke Za Zhi
2020;58(0):E008.
17. Jiehao C, Xiangshi W, Yanling G, et al. La
prima infezione da coronavirus infantile di
Shanghai. Mei Chinese Journal of Pediatrics
2020;58(02):86-7.
18. Niu Y, Yue H. Wuhan Tongji Hospital diagnoses
first case of neonatal infection with
new coronavirus. 5 febbraio 2020. Ultimo accesso:
7 febbraio 2020; articolo in cinese.
http://society.people.com.cn/n1/2020/0205
/c1008-31572959.html.
19. Zhang Z, Wang C, Gao CC. Neonatal coronavirus
expert confirmed at 30 hours of
birth: vertical transmission from mother to
infant. 5 febbraio 2020. Ultimo accesso: 10
febbraio 2020; articolo in cinese. http://
www.cnr.cn/hubei/yuanchuang/20200205/
t20200205_524961963.shtml.
20. Chen H, Guo J, Wang C, et al. Clinical
characteristics and intrauterine vertical transmission
potential of COVID-19 infection in
nine pregnant women: a retrospective review
of medical records. Lancet, pubblicato online
12 febbraio 2020.
21. Laishuan Wang, Yuan Shi, Tiantian Xiao,
et al.; Working Committee on Perinatal and
Neonatal Management for the Prevention
and Control of the 2019 Novel Coronavirus
Infection. Chinese expert consensus on the
perinatal and neonatal management for the
prevention and control of the 2019 novel coronavirus
infection (first edition). Ann Transl
Med 2020;8(3):47.
22. WHO. WHO statement regarding cluster
of pneumonia cases in Wuhan, China. 9 gennaio
2020. Ultimo accesso: 11 febbraio 2020.
https://www.who.int/china/news/detail/09-
01-2020-who-statement-regarding-cluster-ofpneumonia-
cases-in-wuhan-china.
Corrispondenza: vania.giacomet@unimi.it