Ricerca
La profilassi della malattia reumatica in Italia
Acute Rheumatic Fever prophylaxis in high-income countries: clinical observations from an Italian multicentre retrospective study
Andrea Taddio1,2, Roberto Pillon1, Serena Pastore2, Lorenzo Monasta2, Alberto Tommasini2, Caterina Di Battista3, Elisabetta Mascheroni1, Emanuela Berton2, Maria Cristina Maggio4, Gabriele Simonini5, Luciana Breda3, Rolando Cimaz5, Denise Pires Marafon6, Lidia Meli6, Claudia Bracaglia6, Fabrizio De Benedetti6, Alessandro Ventura1,2
1Università di Trieste
2IRCCS Materno-Infantile “Burlo Garofolo”, Trieste
3Dipartimento di Pediatria, Università di Chieti
4Dipartimento Universitario ProSaMI “G. D’Alessandro”, Università di Palermo
5Reumatologia Pediatrica, Ospedale Universitario Pediatrico “Anna Meyer”, Firenze;
6Unità di Reumatologia, Ospedale Pediatrico “Bambino Gesù”, Roma
Aprile 2020 - pagg. 249 -252
Abstract
Objective - The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of Rheumatic Heart Disease (RHD) in a cohort of Italian patients with Acute Rheumatic Fever (ARF).
Methods - This is a multicentre retrospective study. Patients were divided into two groups according to the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated.
Results - wo hundred and ninety patients were enrolled (137 females, 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients showed RHD. Adherence to secondary prophylaxis was low in 26% of patients. The presence of RHD at follow-up was associated with the presence of carditis and its severity at onset (p = 0.001), but it was not related to secondary prophylaxis adherence (p = NS). No association between prophylaxis adherence and ARF recurrence was found p = NS) nor between ARF recurrence and RHD at the end of follow-up (p = NS).
Conclusions - Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm the reported data in a larger population.
Methods - This is a multicentre retrospective study. Patients were divided into two groups according to the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated.
Results - wo hundred and ninety patients were enrolled (137 females, 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients showed RHD. Adherence to secondary prophylaxis was low in 26% of patients. The presence of RHD at follow-up was associated with the presence of carditis and its severity at onset (p = 0.001), but it was not related to secondary prophylaxis adherence (p = NS). No association between prophylaxis adherence and ARF recurrence was found p = NS) nor between ARF recurrence and RHD at the end of follow-up (p = NS).
Conclusions - Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm the reported data in a larger population.
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