Focus
Indagare cum “granuloma” salis: malattia granulomatosa cronica vs malattia di Crohn
To investigate cum “granulomaA” salis: chronic granulomatous disease vs Crohn's disease
Claudia Pantuso1, Michele Citrano2, Mario Giuffrè1, Giovanni Corsello1
1Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna
e Specialistica di Eccellenza “G. D’Alessandro”, Scuola di Specializzazione
in Pediatria, Università di Palermo
2UOC di Pediatria, AO “Ospedali Riuniti Villa Sofia-Cervello”, Palermo
Maggio 2020 - pagg. 315 -316
Abstract
Chronic granulomatous disease (CGD) is a rare inherited disorder of phagocyte oxidative metabolism that, in addition to infectious complications, is characterized by abnormal inflammatory response leading to the formation of granulomas in multiple tissues both in the presence and absence of microorganisms. Inflammation often involves the gastrointestinal tract and the clinical, laboratory, and histological characteristics are hardly distinguishable from Crohn’s disease (CD). CGD is indeed a rare but important differential diagnosis of chronic inflammatory bowel disease (IBD) especially when occurring in early life and its early detection is crucial to improve the prognosis. The paper reports the case of a 2-year-old boy who had a clinical presentation mimicking Crohn’s disease with anal abscess, falling off the growth curve, elevated inflammatory parameters, and iron deficiency anaemia, whose diagnosis proved to be CGD.
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Bibliografia
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Corrispondenza: claudiapantuso@gmail.com