Percorsi clinici
Convulsioni e gastroenterite: un caso che insegna
A case of convulsions with gastroenteritis
Chiara Del Bono1, Federica Ciambrelli1, Alessandro Rocca2, Luca Pierantoni2, Monia Gennari2, Marcello Lanari2
1Scuola di Specializzazione in Pediatria, Alma Mater Studiorum, Università di Bologna
2UO di Pediatria d’Urgenza, IRCCS Azienda Ospedaliero-Universitaria, Policlinico di Sant’Orsola, Bologna
Novembre 2022 - pagg. 589 -592 | DOI: 10.53126/MEB41589
Abstract
The article reports a case of convulsions with gastroenteritis (CWG) and briefly reviews the related literature. A 2-year-old girl presented with four short episodes of focal afebrile seizures within 12 hours. She had fever with vomiting in the previous 2 days and she developed diarrhoea during her hospital stay, after the fifth seizure. She had no significant past medical history and showed neither neurological signs nor signs of dehydration. Serum electrolytes were normal, cerebrospinal fluid examination was negative for meningoencephalitis and contrast-enhanced CT Brain scan showed no evidence of intracranial lesion. Stool investigation was positive for rotavirus. Therefore, the diagnosis of CWG was made. Repeated convulsions were handled with continuous intravenous infusion of midazolam. The main cause of CWGs in viral gastroenteritis is due to rotavirus or norovirus. The convulsions are usually focal seizure clusters, with secondary generalization. CWGs are associated with a benign prognosis.
Riassunto
In questo articolo presentiamo un caso clinico di “convulsioni associate a gastroenterite” e la relativa revisione della letteratura. Il caso presentato è quello di una bambina di 2 anni, ricoverata nel nostro reparto per ripetute crisi convulsive in apiressia in corso di gastroenterite acuta (GEA). Le indagini di laboratorio e strumentali, effettuate sui versanti infettivologico e neurologico, hanno permesso di escludere meningite, encefalite virale e autoimmune, lesioni centrali di tipo neoplastico e ischemico-emorragico. Alla luce del quadro clinico e della positività della ricerca di rotavirus su feci, è stata posta la diagnosi di crisi convulsive in corso di gastroenterite. Le convulsioni ripetute sono state gestite con infusione endovenosa continua di midazolam. Tali episodi convulsivi sono associati a prognosi benigna, similmente a quanto accade per le convulsioni febbrili.
Parole chiave
Classificazione MeSH
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Bibliografia
1. Crichiutti G, I. Poskurica I, Oriole A. Convulsioni in corso di gastroenterite lieve. Medico e Bambino 2010;29(3):165-9.
2. Hartmann H. Benign convulsions with mild gastroenteritis - An underestimated phenomenon? Neuropediatrics 2020;51(5): 313-4. doi: 10.1055/s-0040-1715624.
3. Lee YS, Lee GH, Kwon YS. Update on benign convulsions with mild gastroenteritis. Clin Exp Pediatr 2021 Dec 27. doi: 10.3345/ cep.2021.00997.
4. Sugata K, Taniguchi K, Yui A, et al. Analysis of rotavirus antigenemia and extraintestinal manifestations in children with rotavirus gastroenteritis. Pediatrics 2008;122(2):392-7. doi: 10.1542/peds.2007-2290.
5. Iturriza-Gómara M, Auchterlonie IA, Zaw W, Molyneaux P, Desselberger U, Gray J. Rotavirus gastroenteritis and central nervous system (CNS) infection: characterization of the VP7 and VP4 genes of rotavirus strains isolated from paired fecal and cerebrospinal fluid samples from a child with CNS disease. J Clin Microbiol 2002;40(12):4797-9. doi: 10.1128/JCM.40.12.4797-4799.2002.
6. Maruyama K, Okumura A, Sofue A, Ishihara N, Watanabe K. Ictal EEG in patients with convulsions with mild gastroenteritis. Brain Dev 2007;29(1):43-6. doi: 10.1016/j.braindev. 2006.06.002.
7. Hellysaz A, Hagbom M. Understanding the central nervous system symptoms of rotavirus: A qualitative review. Viruses 2021;13 (4):658. doi: 10.3390/v13040658.
8. Khair AM, Elmagrabi D. Febrile seizures and febrile seizure syndromes: an updated overview of old and current knowledge. Neurol Res Int 2015;2015:849341. doi: 10.1155/ 2015/849341.
9. Uemura N, Okumura A, Negoro T, Watanabe K. Clinical features of benign convulsions with mild gastroenteritis. Brain Dev 2002;24(8):745-9. doi: 10.1016/s0387-7604 (02)00097-9.
10. Iyadurai S, Troester M, Harmala J, Bodensteiner J. Benign afebrile seizures in acute gastroenteritis: is rotavirus the culprit? J Child Neurol 2007;22(7):887-90. doi: 10. 1177/0883073807304703.
11. Abe T, Kobayashi M, Araki K, Kodama H, Fujita Y, Shinozaki T, Ushijima H. Infantile convulsions with mild gastroenteritis. Brain Dev 2000;22(5):301-6. doi: 10.1016/s0387-7604(00)00111-x.
12. Kawase M, Hoshina T, Yoneda T, Kojiro M, Takahashi Y, Kusuhara K. The changes of the epidemiology and clinical characteristics of rotavirus gastroenteritis-associated convulsion after the introduction of rotavirus vaccine. J Infect Chemother 2020;26(3):206-210. doi: 10.1016/j.jiac.2019.09.001.
13. Verrotti A, Nanni G, Agostinelli S, et al. Benign convulsions associated with mild gastroenteritis: a multicenter clinical study. Epilepsy Res 2011;93(2-3):107-14. doi: 10.1016/j. eplepsyres.2010.11.004.
14. Verrotti A, Moavero R, Vigevano F, et al. Long-term follow-up in children with benign convulsions associated with gastroenteritis. Eur J Paediatr Neurol 2014;18(5):572-7. doi: 10.1016/j.ejpn.2014.04.006.
15. Kawano G, Oshige K, Syutou S, et al. Benign infantile convulsions associated with mild gastroenteritis: a retrospective study of 39 cases including virological tests and efficacy of anticonvulsants. Brain Dev 2007;29 (10):617-22. doi: 10.1016/j.braindev.2007.03. 012.
16. Castellazzi L, Principi N, Agostoni C, Esposito S. Benign convulsions in children with mild gastroenteritis. Eur J Paediatr Neurol 2016;20(5):690-5. doi: 10.1016/j.ejpn. 2016.05.014.
17. Capovilla G, Verrotti A. Infantile convulsions in association with mild gastroenteritis: an emerging clinical condition. Eur J Neurol 2011;18(2):203-204. doi: 10.1111/j.1468-1331.2010.03140.x.
18. Okumura A, Uemura N, Negoro T, Watanabe K. Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis. Brain Dev 2004;26(3):164-7. doi: 10.1016/S0387-7604(03)00121-9.
19. Ichiyama T, Matsufuji H, Suenaga N, Nishikawa M, Hayashi T, Furukawa S. [Low-dose therapy with carbamazepine for convulsions associated with mild gastroenteritis]. No To Hattatsu 2005;37(6):493-7.
20. Capovilla G, Vecchi M, Beccaria F, Sartori S, Vigevano F. Trattamento dello stato epilettico convulsivo nel bambino. Raccomandazioni LICE, 2013.
21. Durá-Travé T, Yoldi-Petri ME, Gallinas-Victoriano F, Molins-Castiella T. Infantile convulsions with mild gastroenteritis: a retrospective study of 25 patients. Eur J Neurol 2011;18(2):273-278. doi: 10.1111/j.1468-1331. 2010.03120.x.
22. Ricciarelli P, Magistà A, Currò F, Mambelli L, Marchetti F. Ho le convulsioni e ho avuto un po’ di diarrea. Medico e Bambino pagine elettroniche 2013;16(8).
Corrispondenza: chiara.delbono@studio.unibo.it
