Farmacologia
Adrenalina: tante vie per tante indicazioni
INDICATIONS AND ROUTES OF ADMINISTRATION OF ADRENALINE: WHAT’S NEW
G. Longo1, F. Bradaschia2
1Clinica Pediatrica dell’Università, 2Servizio di Farmacia, IRCCS “Burlo Garofolo”, Trieste
Gennaio 1997 - pagg. 17 -21
Abstract
In recent years, new indications for adrenaline
have been added to the most timehonored
ones, such as anaphylaxis and
cardiopulmonary resuscitation: Alternative
routes of administration have also been
evaluated. For anaphylaxis, nebulised
adrenaline is very effective if administrated
at an early stage and has the advantage of
allowing a quick and easy administration,
thus preventing the progress of anaphylactic
reactions. Findings from recent studies
show that both subcutaneous and nebulized
adrenaline are effective in the treatment
of acute bronchiolitis in infants and
toddlers. Nebulized adrenaline is now an
accepted indication in croup. Most of the
studies in croup and bronchiolitis were made
with racemic adrenaline, but there is
evidence that the laevorotatory form is
equally effective and does not produce cardiac
effects even at relatively high dosages
(0.1 mg/kg in croup and 0.25 mg/kg in
bronchiolitis).
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
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2. Fisher M: Treatment of acute anaphylaxis. B M J 311, 731, 1995.
3. Heilborn H, Hjemdahl P, Daleskog M, Adamsson U: Comparison of subcutaneous injection and high-dose inhalation of epinephrine. Implications for self-treatment to prevent anaphylaxis. J All Clin Immunol 78, 1174, 1986.
4. Patel L, Radivan FS, David TJ: Management of anaphylactic reactions to food (letter). Arch Dis Child 72, 274, 1995.
5. Sanchez I, De Koster J, Powell E, Wolstein R, Chernick V: Effect of racemic epinephrine and salbutamol on clinical score and pulmonary mechanics in infants with bronchiolitis. J Pediatr 122, 145, 1993.
6. Waisman Y, Klein BL, Boenning DA, Young GM, Chamberlain J et al: Prospective randomized double-blind study comparing Lepinephrine and racemic epinephrine aerosols in the treatment of laryngotracheitis (croup). Pediatrics 89, 302, 1992.