Problemi correnti
Iponatremia da trattamento con DDAVP: la desmopressina e l’enuresi notturna
HYPONATREMIA AND SEIZURES FOLLOWING THE ADMINISTRATION OF DDAVP FOR NOCTURNAL ENURESIS
P.P. MOLINARI, A. LAMBERTINI, G. GIOVANNINI, C. MAGNANI, G. AMBROSIONI
Unità Operativa di Pediatria, Ospedale Maggiore “C.A. Pizzardi”, Bologna
Aprile 1998 - pagg. 227 -228
Abstract
Desmopressin (DDAVP) is widely used in
the treatment of primary nocturnal enuresis.
It is a safe and effectiv drug, but occasionally
water intoxication may occur.
We report a 5 - year - old girl who developed
generalized seizures due to hyponatremia,
after a single therapeutic dose of intranasal
DDAVP for enuresis.
Guidelines are given to avoid the risk of
water intoxication following the DDAVP
administration: to exclude from treatment
very young children, to control water intake
before bed time and to control weight at
morning time.
Classificazione MeSH
Bibliografia
1. Moffatt MEK, Harlos S, Kirshen AJ, Burd
L: Desmopressin Acetate and Nocturnal Enuresis:
how much do we know? Pediatrics 92,
420-5, 1993.
2. Miller K, Atkin B, Moody ML: Drug therapy for nocturnal enuresis current treatment recommendations. Drugs 44, 47-56, 1992.
3. Terho P: Desmopressin in nocturnal enuresis. J Urol 145, 818-20, 1991.
4. Robson WLM, Norgaard JP, Leung AKC: Hyponatremia in patients with nocturnal enuresis treated with DDAVP. Eur J Pediatr 155, 959-62, 1996.
5. Blanchard P, Brossier JP: Convulsions par hyponatremie profonde au cours d’un traitement par desmopressine nasale pour enuresie. Arch Fr Pédiatr 48, 589-92, 1991.
6. Kallio J, Rautava P, Hupponen R: Severe hyponatremia caused by intranasal desmopressin for nocturnal enuresis. Acta Paediatr 82, 881-92, 1993.
7. Beach PS, Beach RE, Smith LR: Hyponatremic seizures in a child treated with desmopressin to control enuresis. Clin Pediatr 9, 566-9, 1992.
8. Hamed M, Mitchell H, Clow J: Hyponatraemic convulsion associated with desmopressin and imipramine treatment. BMJ 306, 1169, 1993.
9. Robson WLM, Shashi V, Nagaraj S, Norgaard JP: Water intoxication in a patient with the Prader-Willi Syndrome treated with Desmopressin for nocturnal enuresis. J Urol 157, 646-7, 1997.
10. Simmonds EJ, Mahony MJ, Littlewood JM: Convulsion and coma after intranasal desmopressin in cystic fibrosis. BMJ 297, 1614, 1988.
11. Davis RC, Morris DS, Briggs JE: Nocturnal enuresis (letter). Lancet 340, 1550, 1992.
12. Yaouyanc G, Jonville AP, Yaouyanc-Lapalle H, et al: Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis. Clin Toxicol 30, 637-41, 1992.
13. Schwab M, Wenzel D, Ruder H: Hyponatraemia and cerebral convulsion due to short term DDAVP therapy for control of enuresis nocturnal. Eur J Pediatr 155, 46-8, 1996.
14. Marild S, Jodal U, Jonasson G, Mangelus L, et al: Reference values for renal concentrating capacity in children by the desmopressin test. Pediatr Nephrol 6, 254-7, 1992.
2. Miller K, Atkin B, Moody ML: Drug therapy for nocturnal enuresis current treatment recommendations. Drugs 44, 47-56, 1992.
3. Terho P: Desmopressin in nocturnal enuresis. J Urol 145, 818-20, 1991.
4. Robson WLM, Norgaard JP, Leung AKC: Hyponatremia in patients with nocturnal enuresis treated with DDAVP. Eur J Pediatr 155, 959-62, 1996.
5. Blanchard P, Brossier JP: Convulsions par hyponatremie profonde au cours d’un traitement par desmopressine nasale pour enuresie. Arch Fr Pédiatr 48, 589-92, 1991.
6. Kallio J, Rautava P, Hupponen R: Severe hyponatremia caused by intranasal desmopressin for nocturnal enuresis. Acta Paediatr 82, 881-92, 1993.
7. Beach PS, Beach RE, Smith LR: Hyponatremic seizures in a child treated with desmopressin to control enuresis. Clin Pediatr 9, 566-9, 1992.
8. Hamed M, Mitchell H, Clow J: Hyponatraemic convulsion associated with desmopressin and imipramine treatment. BMJ 306, 1169, 1993.
9. Robson WLM, Shashi V, Nagaraj S, Norgaard JP: Water intoxication in a patient with the Prader-Willi Syndrome treated with Desmopressin for nocturnal enuresis. J Urol 157, 646-7, 1997.
10. Simmonds EJ, Mahony MJ, Littlewood JM: Convulsion and coma after intranasal desmopressin in cystic fibrosis. BMJ 297, 1614, 1988.
11. Davis RC, Morris DS, Briggs JE: Nocturnal enuresis (letter). Lancet 340, 1550, 1992.
12. Yaouyanc G, Jonville AP, Yaouyanc-Lapalle H, et al: Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis. Clin Toxicol 30, 637-41, 1992.
13. Schwab M, Wenzel D, Ruder H: Hyponatraemia and cerebral convulsion due to short term DDAVP therapy for control of enuresis nocturnal. Eur J Pediatr 155, 46-8, 1996.
14. Marild S, Jodal U, Jonasson G, Mangelus L, et al: Reference values for renal concentrating capacity in children by the desmopressin test. Pediatr Nephrol 6, 254-7, 1992.