Per una pediatria basata sull'evidenza
La prevenzione delle malformazioni congenite
PRIMARY PREVENTION OF CONGENITAL MALFORMATIONS
PIERPAOLO MASTROIACOVO
Clinica Pediatrica, Università Cattolica, Roma
Novembre 1998 - pagg. 583 -586
Abstract
The Author reviews the available evidence
on efficacy, risks and effectiveness of the
main interventions aimed at prevention of
congenital malformations (CM): rubeola
immunization, preconceptional folic acid
supplementation, avoidance of smoking
during pregnancy, diabetes control and
avoidance of theratogenic drugs. Expected
results are expressed in terms of number of
CM that could be avoided in Italy by each
intervention. All the interventions appear
cost-effective. Preconceptional administration
of folic acid is the intervention with the
best expected benefit.
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