Problemi non correnti
L’infezione da HCV: ancora molte incertezze
HCV INFECTION: STILL MANY OPEN ISSUES
LUCIA ZANCAN, GIORGIA SVEGLIADO, GRAZIELLA GUARISO
Dipartimento di Pediatria dell’Università di Padova
Maggio 1999 - pagg. 311 -314
Abstract
HCV infection represents an emerging problem in an era of achieved control of HBV infection.
There are still many open issues that the Authors briefly discuss. They regard the mechanisms
of hepatic damage leading to chronic disease in a high proportion of cases, the
importance of early infection, viral load and viral genotype with respect to the ultimate prognosis
of the disease, the timing and mechanisms of vertical transmission. Due to unpredictability
of the effectiveness of treatment with interferon in children, the usefulness of screening
is also open to debate. At present there are no evidence for witholding breastfeeding
in infants from HCV positive mothers.
Classificazione MeSH
Bibliografia
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2. American Academy of Pediatrics: Hepatitis C virus infections. Pediatrics 101, 481-485, 1998.
3. Nowicki M, Balistreri W: The Epatitis C Virus: identification, epidemiology and clinical controversies. J Pediatr Gastroenterol Nutr 20, 248-274, 1995.
4. Ohto H, Terazawa S, Sasaki N, Hino K, Ishiwata C, Kako M, Ujiie N, Endo C, Matsui A, Okamoto H, Mishiros: Transmission of hepatitis C Virus from mother to infants. N Engl J Med 330, 744-50, 1994.
5. Resti M, Azzari C, Lega L, Rossin E, Zammarchi E, Novembre E, Vierucci A: Mother to infant transmission of hepatitis C Virus. Acta Paediatr 84, 251-255, 1995.
6. Giacchino G, Tasso L, Timitilli A, Castagnola E, Cristina E, Sinelli M, Gotta C, Giambartolomei G, Moscatelli P, Piciotto A: Vertical transmission of hepatitis C virus infection: usefulness of viremie detection in HIVseronegative hepatitis C virus-seropositive mothers. J Pediatr 132, 167-169, 1998.
7. Zanetti AR, Tanzi E, Paccagnimi S, Principi M, Pizzocolo G, Caccamo ML, D’Amico E, Cambiè G, Vecchi L: Mother-to-infant transmission of hepatitis C virus. Lancet 345, 289- 291, 1995.
8. Gillet P, Hallan M, Mok J: Vertical transmission of hepatitis C virus infection. Scand J Infect Dis 28, 549-552, 1996.
9. Bortolotti F, Jara P, Diaz C, Vajro P, Hierro L, Giacchino R, De la Vega A, Crivellaro C, Camarena C, Barbera C, Nebbia G, Zancan L, De Molimer L: Post transfusion and community- acquired hepatitis C in childhood. J Pediatr Gastroenterol Nutr 18, 279-283, 1994.
10. Guido M, Rugge M, Jara P, Hierro L, Giacchino R, Larrauri J, Zancan L, Leandro G, Marino CE, Balli F, Bagni A, Timitilli A, Bortolotti F: Chronic hepatitis C in children: the pathological and clinical spectrum. Gastroenterology 115, 1525-1529, 1998.