Aggiornamento monografico
L’infezione da Bartonella henselae nel bambino: una malattia frequente e proteiforme
BARTONELLA HENSELAE INFECTION IN CHILDREN
FRANCESCO MASSEI, FRANCESCO MESSINA1, ILARIA TALINI, MAURO MASSIMETTI, BARBARA LORU, GABRIELLA PALLA, PIERANTONIO MACCHIA, GIUSEPPE MAGGIORE
Dipartimento di Medicina della Procreazione e dell’Etŕ Evolutiva dell’Universitŕ di Pisa
1UO Malattie Infettive, Ospedale di Cisanello, Pisa
Settembre 1999 - pagg. 410 -416
Abstract
The spectrum of clinical manifestations of Bartonella henselae infection in children is changed
in recent years. The clinical features of 20 children with serologically proved B. henselae
infection observed in the last 12 months in the Paediatric Department of the University of
Pisa are described. Patients were 14 males and 6 female with a mean age of 7 years 4
months (range 13 months - 14 years 1 month). Peak incidence occurred in october through
january. All children but one had a history of contact with kittens and in 6 it was possible to
identify the inoculation site. Clinical manifestations included: infectious mononucleosis-like
syndrome in 6, isolated regional lymphoadenopathy in 5, nodous erythema in 3, fever of
unknown origin in 2, and single cases of granulomatous osteitis suggesting bone neoplasm,
marked lymph node enlargement suggesting Burkitt lymphoma, inspissated, ileo-coecal valve
suggesting Crohn’s disease, Parinaud’s oculoglandular syndrome and acute encephalitis.
B. henselae infection is frequent in our geographic area, atypical clinical manifestation are
the most frequent presentation and serology is particularly useful for diagnosis
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
altra patologia da Bartonella. Medico e Bambino
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4. Zancan L, De Carolis G, Monciotti C, Pozzan G, Riello D, Cecchetto G, Talenti E, Toffolutti T, Zacchello F: Granulomi addominali transitori idiopatici: manifestazione atipica della malattia da graffio di gatto? Riv Ital Pediatr 18, 626-30, 1992.
5. Carithers HA: Cat scatch disease: an overview based on a study of 1200 patients. Am J Dis Child 139, 1124-33, 1985.
6. Malatack JJ, Harold AA, Nard JA, Wiener ES, Urback AH, McGregor RS: Cat-scratch disease without adenopathy. J Pediatr 114, 101-4, 1989.
7. Boyer KM: Bartonella (Cat scrach disease). In: Feigin RD and Cherry JD (eds), Textbook of Pediatric Infectious Diseases. WB Sauders Co, 1512-7, 1998.
8. Tolan RW Jr, Schibler KR, Galliani CA, Kleiman NB: Unusual systemic, pseudomalignant manifestation of cat scratch disease in siblings. Pediatr Infect Dis J 9, 913-6, 1990.
9. Ridder GJ, Richter B, Laszig R, Sander A: A farmer with a lump in is throat. Lancet 351, 954, 1998.
10. Raasveld MH, Weel JF, Braat MC, Bakker PJ: Cat-scratch disease mimicking pancreatic malignancy: case report. Clin Infect Dis 24, 77-8, 1997.
11. Maggiore G, Massei F, Bussani R, Ventura A: Bone pain after lymphadenitis. Eur J Pediatr 158, 165-6, 1999.
12. Ventura A Massei F, Not T, Massimetti M, Bussani R, Maggiore G: Systemic Bartonella infection with hepatosplenic involvement. J Pediatr Gastroenterol Nutr, in stampa, 1999.
13. Jacobs RF, Schutze GE: Bartonella henselae as a cause of prolonged fever and fever of unknown origin in children. Clin Infect Dis 26, 80-4, 1998.
14. Riviello JJ Jr, Ruoff KL: Case Records of the Massachusetts General Hospital: An 11 years-old boy with a seizure. N Engl J Med 338, 112-9, 1998.
15. Baorto E, Payde RM, Slater LN, Lopez F, Relman DA, Min KW, St. Geme III JW: Culture- negative endocarditis caused by Bartonella henselae. J Pediatr 132, 1051-4, 1998.
16. Margileth AM: Antibiotic therapy for catscratch disease: clinical study of therapeutic outcome in 268 patients and review of the literature. Pediatr Infect Dis J 11, 474-8, 1992.
2. Bass WJ, Vincent JN, Person DA: The expanding spectrum of Bartonella infections: II. Cat scratch disease. Pediatr Infect Dis J 16, 163-79, 1997.
3. Karpathios T, Golphinos C, Psycou P, Garoufi A, Papadimitriou A, Nicolaidou P: Cat scratch disease in Greece. Arch Dis Child 78, 64-6, 1998.
4. Zancan L, De Carolis G, Monciotti C, Pozzan G, Riello D, Cecchetto G, Talenti E, Toffolutti T, Zacchello F: Granulomi addominali transitori idiopatici: manifestazione atipica della malattia da graffio di gatto? Riv Ital Pediatr 18, 626-30, 1992.
5. Carithers HA: Cat scatch disease: an overview based on a study of 1200 patients. Am J Dis Child 139, 1124-33, 1985.
6. Malatack JJ, Harold AA, Nard JA, Wiener ES, Urback AH, McGregor RS: Cat-scratch disease without adenopathy. J Pediatr 114, 101-4, 1989.
7. Boyer KM: Bartonella (Cat scrach disease). In: Feigin RD and Cherry JD (eds), Textbook of Pediatric Infectious Diseases. WB Sauders Co, 1512-7, 1998.
8. Tolan RW Jr, Schibler KR, Galliani CA, Kleiman NB: Unusual systemic, pseudomalignant manifestation of cat scratch disease in siblings. Pediatr Infect Dis J 9, 913-6, 1990.
9. Ridder GJ, Richter B, Laszig R, Sander A: A farmer with a lump in is throat. Lancet 351, 954, 1998.
10. Raasveld MH, Weel JF, Braat MC, Bakker PJ: Cat-scratch disease mimicking pancreatic malignancy: case report. Clin Infect Dis 24, 77-8, 1997.
11. Maggiore G, Massei F, Bussani R, Ventura A: Bone pain after lymphadenitis. Eur J Pediatr 158, 165-6, 1999.
12. Ventura A Massei F, Not T, Massimetti M, Bussani R, Maggiore G: Systemic Bartonella infection with hepatosplenic involvement. J Pediatr Gastroenterol Nutr, in stampa, 1999.
13. Jacobs RF, Schutze GE: Bartonella henselae as a cause of prolonged fever and fever of unknown origin in children. Clin Infect Dis 26, 80-4, 1998.
14. Riviello JJ Jr, Ruoff KL: Case Records of the Massachusetts General Hospital: An 11 years-old boy with a seizure. N Engl J Med 338, 112-9, 1998.
15. Baorto E, Payde RM, Slater LN, Lopez F, Relman DA, Min KW, St. Geme III JW: Culture- negative endocarditis caused by Bartonella henselae. J Pediatr 132, 1051-4, 1998.
16. Margileth AM: Antibiotic therapy for catscratch disease: clinical study of therapeutic outcome in 268 patients and review of the literature. Pediatr Infect Dis J 11, 474-8, 1992.