Caso contributivo
Trombocitopenia neonatale alloimmune HLA correlata
Neonatal allo-immune thrombocytopoenia (NAIT)
Gianbachisio
Melis1, Maria Rita Gallina2, Patrizia Rosetta3,
Irene Paolucci3, Vanessa Raffa1, Federica
Ferrero2, Andrea Guala1
1SOC pediatria, Ospedale Castelli,
Verbania
2SOC terapia intensiva neonatale
(TIN), Ospedale Maggiore, Novara
3SOC centro trasfusionale, Ospedale
Castelli, Verbania
Dicembre 2013
Abstract
Neonatal allo-immune thrombocytopoenia (NAIT) is a pathology caused by the passage of maternal antibodies against fetal platelet antigens through the placenta. The role of platelet-specific antigens of paternal origin (HPA - Human Platelet Antigen) as responsible of allo-immunization is well documented. On the contrary, the importance of HLA antigens expressed on platelets is still matter of debate. As antibodies anti HLA of class I are often in blood of pregnant women, but rarely they are cause of neonatal cytopoenias, the diagnosis is usually by exclusion.
The article reports a case of NAIT in which the incompatibility to antigens of HLA system has been documented. Although rare, this type of allo-immunization should be considered in cases of neonatal thrombocytopenia.
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