Caso contributivo
Malattia di Graves e iperplasia timica: quale relazione?
Graves’ disease and thymic hyperplasia: what relationship?
Vanna Graziani1, Andrea Zucchini2, Federico Marchetti1
1UOC di Pediatria e Neonatologia, Ospedale di Ravenna e Faenza2, AUSL della Romagna
Gennaio 2016
Classificazione MeSH
Abstract
The case of a 10-year-old girl with clinical hypothyroid-ism in substitution treatment is described. After the on-set of symptoms suggestive of mediastinal mass associ-ated with evolution in hyperthyroidism, she was diag-nosed with thymic hyperplasia in Graves’ disease. The mass regressed after antithyroid treatment. Thymic hy-perplasia is a benign condition that can be associated with Graves’ disease even if symptomatic massive en-largement is rare. The pathogenesis is not well under-stood. Antithyroid drugs usually lead to regression, therefore a correct diagnosis by using imaging tech-niques (echography, MRI, and CT), is essential to avoid unnecessary surgical procedures.
Contenuto riservato
Per leggere l'articolo è necessario effettuare il login.
Parole chiave
Bibliografia
Bibliografia
Chiu HK, Ledbetter D, Richter MW, Iyer RS, Merati AL. Reversible left recurrent laryngeal nerve palsy in pediatric Graves’ disease. Pediatrics 2013;132(6):e1704-8.
Chow WS, Kung AW. An adolescence girl with an anterior mediastinal mass. Self-assessment questions. Postgrad Med J 2000;76:55-6.
Pellegrin MC, Patti G, Faleschini E, Tornese G, Guastalla P, Ventura A. Il timo ectopico nella diagnosi dif-ferenziale delle masse del collo. Medico e Bambino 2014;33:579-84.
Bruno I. La malattia di Graves-Basedow in pediatria. Medico e Bambino 2011;30(2):122-3.
Chiarelli F, Agostinelli S. Le patologie della tiroide nell’infanzia e nell’adolescenza. Medico e Bambino 2012;31(3):157-67.
Kubicky RA, Faerber EN, De Chadarevian JP, Wu S, Rezvani I, De Luca F. An adolescent with a mediastinal mass, diagnosed with Graves disease and thymic hyperplasia. Pediatrics 2010;125:e433-7.
Kawano A, Kohno H. Thymic hyperplasia associated with Graves’ disease in a 10-year-old boy. Clin Pediatr Endocrinol 2011;20(3):61-4.
Hamzaoui AA, Klii RR, Salem RR, Kochtali II, Golli MM, Mahjoub SS. Thymic hyperplasia in a patient with Grave’s disease. Int Arch Med 2012;5:6.
Murakami M, Hosoi Y, Negishi T, et al. Thymic hyperplasia in patients with Graves’ disease: identification of thyrotropin receptors in human thymus. J Clin Invest 1996;98:2228-34.
Suh H, Rosen JE, Doherty GM, Saunders BD, McAneny D. Graves’ disease and thymic hyperplasia. Surgery 2013;154:1473-7.
Scheiff JM, Cordier AC, Haumont S. Epithelial cell proliferation in thymic hyperplasia induced by triiodo-thyronine. Clin Exp Immunol 1977;27:516-21.
Desforges-Bullet V, Petit-Aubert G, Collet-Gaudillat C, et al. Thymic hyperplasia and Graves’ disease: a non-fortuitous association. case report and review of literature. Ann Endocrinol (Paris) 2011;72(4):304-9.
Weetman AP, McGregor AM, Hall R. Evidence for an effect of antithyroid drugs on the natural history of Graves’ disease. Clin Endocrinol (Oxf) 1984;21:163-72.
Kotwal N, Singh Y, Menon A, Behera V. Thymic hyperplasia in Graves’ disease. Indian J Endocrinol Metab 2013;17(3):521-3.
Budavari AI, Whitaker MD, Helmers RA. Thymic hyperplasia presenting as anterior mediastinal mass in 2 patients withGraves’ disease. Mayo Clin Proc 2002;77:495-9.
