Neonatal mastitis with possible abscess complication is relatively rare. The most common causal agent is Staphylococcus aureus. The paper describes the case of a newborn of 8 days of life, with fever and bilateral mastitis. The newborn was treated with antibiotic therapy with vancomicin and gentamicin and required the right breast surgical drainage for abscess complication. Culture of the pus yielded a pure growth of methicillin-resistant Staphylococcus aureus. The mother of the newborn presented with mastitis that developed a few days earlier. Complications of neonatal mastitis are rare nonetheless cellulitis, fasciitis, osteomyelitis, meningitis, brain abscess and sepsis have been reported. It is therefore essential to treat the mastitis of the newborn promptly and take into consideration the possible resistance of Staphylococcus that is the main etiological agent. Therefore, possible abscess complications need to be treated surgically.