Macrohaematuria and microhematuria may be signs of various diseases. Infectious haematuria often presents with fever and/or dysuria. The paper describes the case of a 14-year-old boy from Mali who was in Italy for five months and presented with gross haematuria and dysuria for three weeks. He was afebrile and denied abdominal symptoms. The physical examination was normal. The blood count showed absolute hypereosinophilia and mild microcytic anaemia. The analysis of the urine showed proteinuria and haemoglobinuria, while the urine culture was negative. Ultrasound of the urinary tract revealed a periurethral microcyst. The search for Plasmodium falciparum (PH) was positive (parasitaemia < 0.1%). Given the haematuria and hypereosinophilia, serological tests were carried out for intestinal parasites and revealed anti-schistosome IgG antibodies positivity. Microscopic analysis of the urinary sediment high-lighted the presence of SH eggs. Dihydroartemisinine-piperaquine and praziquantel were administered. Recent migratory flows and climate change have increased the spread of tropical diseases in Italy. A diagnostic process that integrates anamnesis and epidemiological notions is essential.