Percorsi clinici
“Dottore, mio figlio ha una manina piů grossa dell’altra”: l’iperaccrescimento lateralizzato
“Doctor, my son has a hand bigger than the other”: how to deal with lateralised overgrowth
Rodaro C, Baldo F.
Maggio 2026 - pagg. 317 -322 | DOI: 10.53126/MEB45317
Abstract
Lateralised overgrowth is a clinical entity that paediatricians need to know because it may suggest the presence of genetic syndromes with increased cancer risk. The paper presents two clinical cases of patients with lateralised overgrowth. It then replies to some questions that either the paediatrician or the family of the child might pose and aims to clarify the importance of ensuring appropriate follow-up care.
Riassunto
L’iperaccrescimento lateralizzato č un’entitŕ clinica che i pediatri devono conoscere in quanto spia di sindromi genetiche associate a rischio tumorale. In questo articolo presentiamo due casi clinici di pazienti che si sono presentati nell’ambulatorio del pediatra di famiglia con questo quadro. Rispondiamo poi ad alcune domande che il pediatra stesso o la famiglia del bambino potrebbero porsi, con il fine di chiarire l’importanza di seguire un corretto follow-up.
Classificazione MeSH
Contenuto riservato
Per leggere l'articolo completo è necessario effettuare il login.
Non sei ancora registrato? Registrati
Vuoi acquistare solo questo articolo? Scrivi a abbonamenti@medicoebambino.com.
Bibliografia
1. El-Darouti MA, Al-Ali FM. A Child with Hemihypertrophy, Omphalocele, and Organomegaly. In: Challenging Cases in Dermatology Volume 2. Cham: Springer International Publishing, 2019. p. 67-73.
2. De Pellegrin M, Brogioni L, Laskow G,et al. Guided Growth in Leg Length Discrepancy in Beckwith-Wiedemann Syndrome: A Consecutive Case Series. Children (Basel) 2021;8(12):1152. doi: 10.3390/children 8121152.
3. Kalish JM, Biesecker LG, Brioude F, et al. Nomenclature and definition in asymmetric regional body overgrowth. Am J Med Genet A 2017;173(7):1735-8. doi: 10.1002/ajmg.a. 38266.
4. Mark C, Hart C, McCarthy A, Thompson A. Fifteen-minute consultation: Assessment, surveillance and management of hemihypertrophy. Arch Dis Child Educ Pract Ed 2018;103(3):114-7. doi: 10.1136/archdischild-2017-312645.
5. Mussa A, Carli D, Cardaropoli S, Ferrero GB, Resta N. Lateralized and Segmental Overgrowth in Children. Cancers (Basel) 2021;13(24):6166. doi: 10.3390/cancers 13246166.
6. Jones SM, Rahman RS, Bourgeois DJ 3rd, Steele RW, Halat S. Hemihyperplasia in a 4-month-old. Clin Pediatr (Phila) 2011;50(4): 367-71. doi: 10.1177/0009922810397337.
7. Romaris MJ, Caino S, Adamo P, Fano V. Isolated lateralized overgrowth: clinical, radiological, and auxological characteristics of a single-site cohort of 76 cases. Arch Argent Pediatr 2022;120(6):405-14. English, Spanish. doi: 10.5546/aap.2022.eng.405.
8. Brioude F, Kalish JM, Mussa A, et al. Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement. Nat Rev Endocrinol 2018;14(4):229-49. doi: 10.1038/nrendo.2017.166.
9. Mussa A, Russo S, De Crescenzo A, et al. Prevalence of Beckwith-Wiedemann syndrome in North West of Italy. Am J Med Genet A 2013 ;161A(10):2481-6. doi: 10.1002/ajmg.a. 36080.
10. Mussa A, Molinatto C, Cerrato F, et al. Assisted Reproductive Techniques and Risk of Beckwith-Wiedemann Syndrome. Pediatrics 2017;140(1):e20164311. doi: 10.1542/ peds.2016-4311.
11. Vaiman M, Shilco P, Roitblat Y, et al. Hemihyperplasia/hemihypertrophy in adolescents: prospective international study. Int J Adolesc Med Health 2019;33(1). doi: 10.1515/ijamh-2018-0066.
12. Hoyme HE, Seaver LH, Jones KL, Procopio F, Crooks W, Feingold M. Isolated hemihyperplasia (hemihypertrophy): report of a prospective multicenter study of the incidence of neoplasia and review. Am J Med Genet 1998;79(4):274-8.
13. Radley JA, Connolly M, Sabir A, et al. Isolated- and Beckwith-Wiedemann syndrome related- lateralised overgrowth (hemihypertrophy): Clinical and molecular correlations in 94 individuals. Clin Genet 2021;100(3):292-7. doi: 10.1111/cge.13997.
14. Prada E, Selicorni A. La sindrome di Beckwith-Wiedemann. Medico e Bambino. 2023;42(7):457–9. doi: 10.53126/MEB42457.
15. De Paoli A, Di Francesco A, Selicorni A. La sindrome di Beckwith-Wiedemann. Medico e Bambino.2019;38(8):509-17.
16. Giżewska-Kacprzak K, Śliwiński M, Nicieja K, Babiak-Choroszczak L, Walaszek I. Macrodactyly. Children (Basel) 2024;11(7): 753. doi: 10.3390/children11070753.
17. Panteliadis CP. Klippel-Trénaunay Syndrome (Klippel-Trénaunay-Weber Syndrome). In: Neurocutaneous Disorders. Cham: Springer International Publishing; 2022. p. 135-42.
Corrispondenza: chiara.rodaro@studenti.units.it