Aggiornamento monografico
Le malattie autoimmuni della cute
AUTOIMMUNE SKIN DISEASES
CRISTIANA MALORGIO, FRANCO PANIZON
Clinica Pediatrica, IRCCS “Burlo Garofolo”, Trieste
Ottobre 2000 - pagg. 495 -503
Abstract
Autoimmune skin diseases are analytically described on the basis of the information known
on their self-aggressive pathogenesis. These descriptions are followed by an explanation of
the criteria used to assign the “autoimmune” label to each disease: immunofluorescence
(with reference to psoriasis, alopecia, vitiligo, pemphigus and pemphigoids, Duhring’s disease,
linear IgA, discoid lupus, lichen); identification of target antigen and relevant antibody
(with reference to psoriasis, alopecia, vitiligo, pemphigus and pemphigoids, Duhring’s
disease, chronic urticaria); association with other autoimmune diseases (with reference
to psoriasis, alopecia, 20 nail dystrophy, pemphigus, Duhring’s disease, discoid lupus,
lichen, chronic urticaria, kelis, granuloma annulare, vasculitis, erithema diutinum); transmission
or recovery by grafting T-lymphocytes or marrow (with reference to psoriasis, alopecia,
pemphigus and pemphigoids, vitiligo); mother-child transmission (gravidic pemphigoid).
Next, the most effective therapeutic indications for each disease are given: local or general
corticosteroids (with reference to psoriasis, alopecia, vitiligo, pemphigus and pemphigoids,
discoid lupus, lichen, urticaria, kelis); ultraviolet rays (with reference to psoriasis, alopecia,
vitiligo, Duhring’s disease, urticaria).
Parole chiave
20 nail dystrophy
Alopecia
autoimmune skin diseases
Chronic urticaria
Discoid lupus
Distrofia delle 20 unghie
Duhring's disease
eritema diutino
Erithema diutinum
Granuloma annulare
granuloma anulare
Kelis
Lichen
Linear IgA
Lupus discoide
Malattie autoimmuni della pelle
malattie della pelle autoimmuni
Morfea
Morphea
Orticaria cronica
pemfigo e pemfigoidi
Pemphigus and pemphigoids
Psoriasi
Psoriasis
Vasculite
Vasculitis
Vitiligine
Vitiligo
Suggerite dall'AI
Classificazione MeSH
Bibliografia
PSORIASI
Suader DN, Bailin PL, Sundeen J, Krakauer
RS. Suppressor cell function in psoriasis. Arch
Dermatol 1980;16:51.
Reewes WH. Autoimmunity mechanisms in
psoriasis. Semin Dermatol 1991;10:217.
Beutner EH, Jarzabek-Chorelska M, Jablonska
S, et al. Autoimmunity in psoriasis. A
complement immunofluorescence study. Arch
Dermatol Res 1978;261:123.
Jablonska S, Chorezelski TP, Beutner EH, et
al. Autoimmunity in psoriasis. Relation of disease
activity and forms of psoriasis to immunofluorescence
findings. Arch Dermatol Res
1978;261:135.
Daikeler T, Gunaydin I, Einsele H, et al.
Transmission of psoriasic arthritis by allogeneic
bone marrow transplantation for chronic
myelogenous leukemia from an HLA-identical
donor. Rheumatology 1999;38:89.
Snowden JA, Heaton DC. Development of
psoriasis after syngeneic bone marrow transplant
from psoriasic donor: further evidence
for adoptive autoimmunity. Br J Dermatol
1997;137:130.
Sverlick AA, Lawley T. Eczema, psoriasis, cutaneous
infections and other common skin
desorders. In: Harrison’s Principles of medicine,
14th ed. Fauci AS, et al (Eds), pag 298,
Graham Hill, 1998.
Bolognie JL. Skin manifestation of internal
diseases CS, pag 298.
Wolff K, Kibbi AG, Mihm MC. Basic pathologic
reactions of the skin. In: Dermatology in
General Medicine. 3th ed. Fitzpatrick AZ et
al (Eds), McGraw Hills, 1994.
ALOPECIA
Levin RM, Travis SF, Heymann WR. Simultaneous
onset of alopecia areata and idiopathic
thrombocytopenic purpura: a potential association?
Pediatr Dermatol 1999;16:31.
Boni R, Trueb RM, Wuthrich B. Alopecia
areata in a patient with candidiasis-endocrinopathy
syndrome: unsuccessful treatment
with diphenylcyclopropenone. Dermatology
1995;191:68.
McDonagh AJ, Messenger AG. The aetiology
and pathogenesis of areata. J Dermatol
Sci 1994;(Suppl S):125-7.
Hedstrand H, Ekwall O, Haavik J, et al. Identification
of tyrosine hydroxylase as an autoantigen
in autoimmune polyendocrine syndrome
type I. Biochem Biopys Res Commun
2000;7:267.
Hedstrand H, Perheentupa J, Ekwall O, et al.
Antibodies against hair follicles are associated
with alopecia totalis in autoimmune
polyendocrine syndrome type I. J Investig
Dermatol 1999;113:1054.
Gilhar A, Shalaginov R, Assy B, et al. Alopecia
areata is a T-lymphocyte mediated autoimmune disease: lesional human Tlymphocytes
transfer alopecia areata to human
skin graft on SCID mice. J Investig Dermatol
Symp Proc 1999;4:207.
Hoffmann R. The potential role of cytokines
and T cells in alopecia areata. J Investig Dermatol
Symp Proc 1999;4:235.
La bibliografia completa all'interno del PDF.