Problemi non correnti
Anemia sideropenica associata a infezione da Helicobacter pylori
IRON DEFICIENCY ANAEMIA ASSOCIATED TO HELICOBACTER PYLORI INFECTION
ARRIGO BARABINO
Gastroenterologia Pediatrica, Istituto “G. Gaslini”, Genova
Aprile 2001 - pagg. 241 -243
Abstract
Iron deficiency anaemia may be associated to Helicobacter pylori (Hp) infection, as well as
other extra-intestinal manifestations such as growth faltering, migraine, auto-immune disease
and MALT lymphoma. The relationship between iron deficiency anaemia and Hp infection,
first described by the Author, was then confirmed by subsequent studies. Anaemia
is not due to intestinal losses, nor to reduced iron absorption, but to increased production
and saturation of lactoferrin in the gastric mucus. Lactoferrin is then captured by a specific
receptor of the cell wall of Hp, which thus is competing with the host for the iron utilisation.
Parole chiave
Suggerite dall'AI
Classificazione MeSH
Bibliografia
1. Konturek Sj, Konturek PC, Pieniazek P,
Bielanski W. Role of Helicobacter pylori infection
in extragastroduodenal disorders: introductions
remarks. J Physiol Pharmacol 1999;
50:683-94.
2. Dufour C, Brisigotti M, Fabretti G, Luxardo P, Mori PG, Barabino A. Helicobacter pylori gastric infection and sideropenic refractory anemia. J Pediatr Gastroenterol Nutr 1993; 17:225-7
3. Carnicier J, Badia R, Argemě J. Helicobacter pylori gastritis and sideropenic refractory anemia. J Pediatr Gastroenterol Nutr 1997; 24;441.
4. Marignani M, Angeletti S, Bordi C, Malagnino F, Mancino C, Delle Fave G, Annibale B. Reversal of long-standing iron deficiency anemia after eradication of Helicobacter pylori infection. Scand J Gastroenterol 1997;32:617- 22.
5. Barabino A, Dufour C, Marino CE, Claudiani F, De Alessandri A. Unexplained refractory anemia associated with Helicobacter pylori gastric infection in children: further clinical evidence. J Pediatr Gastroenterol Nutr 1999;28:116-9.
6. Annibale B, Marignani M, Monarca B, Antonelli G, Marcheggiano A, Martino G, Mandelli F, et al. Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Ann Intern Med 1999;131:668-72.
7. Choe YH, Kim SK, Son BK, Lee DH, Hong YC, Pai SH. Randomized placebo-controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents. Helicobacter 1999;4: 135-9.
8. Konno M, Muraoka S, Takahashi M, Imai T. Iron-deficiency anemia associated with Helicobacter pylori gastritis. J Pediatr Gastroenterol Nutr 2000;31:52-6.
9. Milman N, Rosenstock S, Andersen L, Jorgensen T, Bonnevie O. Serum ferritin, hemoglobin, and Helicobacter pylori infection: a seroepidemiologic survey comprising 2794 Danish adults. Gastroenterology 1998;115:268- 74.
10. Peach HG, Bath NE, Farish SJ. Helicobacter pylori infection: an added stressor on iron status of women in the community. Med J Aust 1998;169:188-90.
11. Hodgins S, Dewailly E, Chatwood S, Bruneau S, Bernier F. Iron-deficiency anemia in Nunavik: pregnancy and infancy. Int J Circumpolar Health 1998;57:135-40.
12. Choe YH, Kim SK, Hong YC. Helicobacter pylori infection with iron deficiency anaemia and subnormal growth at puberty. Arch Dis Child 2000;82:136-40.
13. Choe YH, Lee JE, Kim SK. Effect of Helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection. Acta Pediatr 2000;89:154-7.
14. Lewis SM. Erythropoiesis. In: AU Hoffbrand, Lewis SM eds. Postgraduate haematology. Oxford: Heineman, 1990:1-25.
15. Bullen JJ, Ward CG, Rogers HJ. The critical role of iron in some clinical infections. Eur J Clin Microbiol Infect Dis 1991;10:613-7.
16. Otto BR, Verweij-van Vught AMJJ, MacLaren DM. Transferrin and heme-compounds as iron sources for pathogenic bacteria. Critical Rev Microbiol 1992;18:217-33.
17. Payne SM. Iron acquisition in microbial pathogenesis. Trends Microbiol 1993;1:66-9.
18. Husson MO, Legrand D, Spick G, Leclerc H. Iron acquisition by Helicobacter pylori: importance of human lactoferrin. Infect Immun 1993;61:2694-7.
19. Luqmani YA, Campbell TA, Bennett C, Coombes RC, Paterson IM. Expression of lactoferrin in human stomach. Int J Cancer 1991;49:684-7.
20. Dhaenens L, Szczebara F, Husson MO. Identification, characterization and immunogenicity of the lactoferrin-binding protein from Helicobacter pylori. Infect Immun 1997;65:514-8.
21. Nakao K, Imoto I, Ikemura N, Shibata T, Takaji S, Taguchi Y, Misaki M, et al. Relation of lactoferrin levels in gastric mucosa with Helicobacter pylori infection and with the degree of gastric inflammation. Am J Gastroenterol 1997;92:1005-11.
22. Nakao K, Imoto I, Gabazza EC, Yamauchi K, Yamazachi N, Taguchi Y, Shibata T, et al. Gastric juice levels of lactoferrin and Helicobacter pylori infection. Scand J Gastroenterol 1997;32:530-4.
23. Frazier BA, Pfeifer JD, Russel DG, Falk P, Olsen AN, Hammar M, Westblom TU, et al. Paracrystalline inclusions of a novel ferritin containing nonhem iron, produced by the human pathogen Helicobacter pylori: evidence for a third class of ferritins. J Bacteriol 1993;175:966-72.
2. Dufour C, Brisigotti M, Fabretti G, Luxardo P, Mori PG, Barabino A. Helicobacter pylori gastric infection and sideropenic refractory anemia. J Pediatr Gastroenterol Nutr 1993; 17:225-7
3. Carnicier J, Badia R, Argemě J. Helicobacter pylori gastritis and sideropenic refractory anemia. J Pediatr Gastroenterol Nutr 1997; 24;441.
4. Marignani M, Angeletti S, Bordi C, Malagnino F, Mancino C, Delle Fave G, Annibale B. Reversal of long-standing iron deficiency anemia after eradication of Helicobacter pylori infection. Scand J Gastroenterol 1997;32:617- 22.
5. Barabino A, Dufour C, Marino CE, Claudiani F, De Alessandri A. Unexplained refractory anemia associated with Helicobacter pylori gastric infection in children: further clinical evidence. J Pediatr Gastroenterol Nutr 1999;28:116-9.
6. Annibale B, Marignani M, Monarca B, Antonelli G, Marcheggiano A, Martino G, Mandelli F, et al. Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Ann Intern Med 1999;131:668-72.
7. Choe YH, Kim SK, Son BK, Lee DH, Hong YC, Pai SH. Randomized placebo-controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents. Helicobacter 1999;4: 135-9.
8. Konno M, Muraoka S, Takahashi M, Imai T. Iron-deficiency anemia associated with Helicobacter pylori gastritis. J Pediatr Gastroenterol Nutr 2000;31:52-6.
9. Milman N, Rosenstock S, Andersen L, Jorgensen T, Bonnevie O. Serum ferritin, hemoglobin, and Helicobacter pylori infection: a seroepidemiologic survey comprising 2794 Danish adults. Gastroenterology 1998;115:268- 74.
10. Peach HG, Bath NE, Farish SJ. Helicobacter pylori infection: an added stressor on iron status of women in the community. Med J Aust 1998;169:188-90.
11. Hodgins S, Dewailly E, Chatwood S, Bruneau S, Bernier F. Iron-deficiency anemia in Nunavik: pregnancy and infancy. Int J Circumpolar Health 1998;57:135-40.
12. Choe YH, Kim SK, Hong YC. Helicobacter pylori infection with iron deficiency anaemia and subnormal growth at puberty. Arch Dis Child 2000;82:136-40.
13. Choe YH, Lee JE, Kim SK. Effect of Helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection. Acta Pediatr 2000;89:154-7.
14. Lewis SM. Erythropoiesis. In: AU Hoffbrand, Lewis SM eds. Postgraduate haematology. Oxford: Heineman, 1990:1-25.
15. Bullen JJ, Ward CG, Rogers HJ. The critical role of iron in some clinical infections. Eur J Clin Microbiol Infect Dis 1991;10:613-7.
16. Otto BR, Verweij-van Vught AMJJ, MacLaren DM. Transferrin and heme-compounds as iron sources for pathogenic bacteria. Critical Rev Microbiol 1992;18:217-33.
17. Payne SM. Iron acquisition in microbial pathogenesis. Trends Microbiol 1993;1:66-9.
18. Husson MO, Legrand D, Spick G, Leclerc H. Iron acquisition by Helicobacter pylori: importance of human lactoferrin. Infect Immun 1993;61:2694-7.
19. Luqmani YA, Campbell TA, Bennett C, Coombes RC, Paterson IM. Expression of lactoferrin in human stomach. Int J Cancer 1991;49:684-7.
20. Dhaenens L, Szczebara F, Husson MO. Identification, characterization and immunogenicity of the lactoferrin-binding protein from Helicobacter pylori. Infect Immun 1997;65:514-8.
21. Nakao K, Imoto I, Ikemura N, Shibata T, Takaji S, Taguchi Y, Misaki M, et al. Relation of lactoferrin levels in gastric mucosa with Helicobacter pylori infection and with the degree of gastric inflammation. Am J Gastroenterol 1997;92:1005-11.
22. Nakao K, Imoto I, Gabazza EC, Yamauchi K, Yamazachi N, Taguchi Y, Shibata T, et al. Gastric juice levels of lactoferrin and Helicobacter pylori infection. Scand J Gastroenterol 1997;32:530-4.
23. Frazier BA, Pfeifer JD, Russel DG, Falk P, Olsen AN, Hammar M, Westblom TU, et al. Paracrystalline inclusions of a novel ferritin containing nonhem iron, produced by the human pathogen Helicobacter pylori: evidence for a third class of ferritins. J Bacteriol 1993;175:966-72.