Percorsi clinici
Dermatomiositi allo specchio
Paediatric dermatomyositis: description of two cases
Sara Della Paolera*, Lorenzo Mambelli, Elena Zamuner, Federico Marchetti
UOC di Pediatria e Neonatologia, Ospedale di Ravenna, AUSL della Romagna
*Università di Trieste
Giugno 2016 - pagg. 381 -385
Abstract
Dermatomyositis is a rare autoimmune disease that first affects the proximal muscles of the
limbs and skin. The paper describes two cases of dermatomyositis with non-classic symptoms.
In the first case the clinical aspects and the positivity for anti-PM/Scl antibodies suggest
a diagnosis of overlap syndrome, commonly defined as mixed connectivitis. The second
case, instead, regards a hypomyopathic dermatomyositis, a rare condition presenting only
with the cutaneous damage and not the muscular one. Some remarkable aspects of the diagnosis
and treatment of classic dermatomyositis with its possible variants are summarised.
Classificazione MeSH
Contenuto riservato
Per leggere l'articolo completo è necessario effettuare il login.
Non sei ancora registrato? Registrati
Bibliografia
1. Kliegman RM, Stanton BMD, St Geme J,
Schor NF. Nelson textbook of pediatrics. 20th
ed. Elsevier (Ed), 2015.
2. Feldman BM, Rider LG, Reed AM, Pachman
LM. Juvenile dermatomyositis and other idiopathic
inflammatory myopathies of childhood.
Lancet 2008;371(9631):2201-12.
3. Taddio A, Tommasini A. La Dermatomiosite
Giovanile. In: Lepore L (a cura di). Reumatologia
per il pediatra. Medico e Bambino (Ed),
2014:377-86.
4. Rider LG, Nistala K. The juvenile idiopathic
inflammatory myopathies: pathogenesis, clinical
and autoantibody phenotypes, and outcomes.
J Intern Med 2016;280(1):24-38.
5. Richardson AE, Warrier K, Vyas H. Respiratory
complications of the rheumatological diseases
in childhood. Arch Dis Child 2016 Jan
14 [Epub ahead of print].
6. Danieli MG, Gelardi C, Guerra F, Cardinaletti
P, Pedini V, Gabrielli A. Cardiac involvement
in polymyositis and dermatomyositis. Autoimmun
Rev 2016;15(5):462-5.
7. Dalakas MC, Hohlfeld R. Polymyositis and
dermatomyositis. Lancet 2003;362(9388):971-
82.
8. Berard RA, Laxer RM. Pediatric mixed connective
tissue disease. Curr Rheumatol Rep
2016;18(5):28.
9. Ghirardello A, Borella E, Beggio M, Franceschini
F, Fredi M, Doria A. Myositis autoantibodies
and clinical phenotypes. Auto Immun
Highlights 2014;5(3):69-75.
10. Gerami P, Walling HW, Lewis J, Doughty
L, Sontheimer RD. A systematic review of juvenile-
onset clinically amyopathic dermatomyositis.
Br J Dermatol 2007;157(4):637-44.
11. Walling HW, Gerami P, Sontheimer RD. Juvenile-
onset clinically amyopathic dermatomyositis:
an overview of recent progress in
diagnosis and management. Paediatr Drugs
2010;12(1):23-34.
12. Gerami P, Schope JM, McDonald L, Walling
HW, Sontheimer RD. A systematic review
of adult-onset clinically amyopathic dermatomyositis
(dermatomyositis siné myositis): a
missing link within the spectrum of the idiopathic
inflammatory myopathies. J Am Acad
Dermatol 2006;54(4):597-613.
13. Ruperto N, Pistorio A, Oliveira S, et al.; Paediatric
Rheumatology International Trials Organisation
(PRINTO). Prednisone versus prednisone
plus ciclosporin versus prednisone plus
methotrexate in new-onset juvenile dermatomyositis:
a randomised trial. Lancet 2016;387
(10019):671-8.
14. Wright NA, Vleugels RA, Callen JP. Cutaneous
dermatomyositis in the era of biologicals.
Semin Immunopathol 2016;38(1):113-21.
15. Iorizzo LJ 3rd, Jorizzo JL. The treatment
and prognosis of dermatomyositis: an updated
review. J Am Acad Dermatol 2008;59(1):99-112.
16. Pelle MT, Callen JP. Adverse Cutaneous
Reactions to Hydroxychloroquine Are More
Common in Patients With Dermatomyositis
Than in Patients With Cutaneous Lupus
Erythematosus. Arch Dermatol 2002;138(9):
1231-3.
Corrispondenza: federico.marchetti@ausl.ra.it