Aggiornamento
La leucemia ridotta all’osso: fatti e misfatti
Bone pain underlying leukaemia
Antonio Giacomo Grasso1, Caterina Radice2, Francesca Corrias1, Federico Verzegnassi1, Federico Marchetti2
1IRCCS Materno-Infantile “Burlo Garofolo”, Universitŕ di Trieste
2UOC di Pediatria e Neonatologia, Ospedale di Ravenna, AUSL della Romagna
Settembre 2017 - pagg. 428 -434
Abstract
Acute Lymphoblastic Leukaemia (ALL) is the most common cancer disease in paediatric
age. Even though in the last decade there has been a steady improve of the chances of
survival from this disease, it is relatively uncommon in the life of a general paediatrician
and still currently causes 30% of deaths by cancer in paediatric age. Diagnosis is sometimes
delayed because of a scarce knowledge of the early or unusual signs underlying
ALL onset. Through the analysis of three different cases, this article aims to refresh the
models of presentation of this disease by focusing on the musculoskeletal and articular
signs and symptoms. ALL should always be considered in children with musculoskeletal
symptoms, especially when the clinical pattern is not characteristic of a specific rheumatic
disease. Routine laboratory tests may be misleading. The simultaneous presence of
high LDH and raised ESR or CRP, even with normal blood cell counts, should lead to additional
investigations.
Classificazione MeSH
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Corrispondenza: antonioggrasso@gmail.com