Hematologic Tests

Trombocitopenia immune: quando le immunoglobuline non funzionano

Iannicelli A, Vorini MV, Beneduce G, Giagnuolo G, Parasole R, Menna G

2025/6 — pag. 162-163 — DOI

A 9-year-old boy was initially evaluated for macrocytic anaemia, neutrophilic leukocytosis and thrombocytopenia, with spontaneous ecchymoses but with no significant medical history. After ten months of follow-up, hematologic worsening occurred alongs...

"Amici per la pelle": un caso di leishmaniosi

Fantasia M, Vecchi M, Cavalleri L, Bruni F, Provenzi M

2025/4 — pag. 81-85 — DOI

Leishmaniasis is an infectious disease caused by protozoa of the Leishmania genus, parasites of humans and several domestic and wild animals, and transmitted via vectors. The authors describe the case of an 18-month-old girl, presenting to the Emerge...

Leishmania e linfoistiocitosi emofagocitica (HLH)

Bratta A, Arcuri L, Micalizzi C

2025/2 — pag. 51-52 — DOI

Haemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening hyperinflammatory syndrome. The paper reports the case of a 5-month-old infant hospitalised with persistent fever, splenomegaly and significant inflammatory activation. After an ini...

Un caso di anemia macrocitica non megaloblastica: la sindrome di Blackfan Diamond

Aquisti G, Basso ME, Rabbone I

2024/5 — pag. 92-93 — DOI

The case of a two-year-old child with severe isolated anaemia (6 g%) and marked macrocytosis, ultimately diagnosed as Blackfan Diamond syndrome, is described. The genetic, clinical and prognostic aspects of the disease are briefly discussed....

Sferocitosi: una famiglia... tre malattie!

Ferrara D, Giordano C, Borsellino Z, Cuccia L, Ruffo GB, Corsello G.

2024/1 — pag. 54-57 — DOI

The paper describes the cases of three siblings affected by Hereditary Spherocytosis (HS). The different clinical presentations in the same family are examples of the heterogeneity of this pathology. HS is a common inherited type of haemolytic anaemi...

Sferocitosi: una famiglia... tre malattie!

Ferrara D, Giordano C, Borsellino Z, Cuccia L, Ruffo GB, Corsello G

2024/1 — pag. 5-8 — DOI

The paper describes the cases of three siblings affected by Hereditary Spherocytosis (HS). The different clinical presentations in the same family are examples of the heterogeneity of this pathology. HS is a common inherited type of haemolytic anaemi...

Le prove coagulative nel bambino sano (seconda parte)

Romano F, Del Monte F, Ramenghi U, Parodi E.

2023/5 — pag. 307-311 — DOI

In Paediatrics, coagulation tests are often prescribed in children without bleeding symptoms, for example before surgery/invasive procedures, or in case of family history of coagulopathy. Moreover, sometimes impairment in coagulation tests is occasio...

Le prove coagulative nel bambino che sanguina (prima parte)

Del Monte F, Romano F, Parodi E, Ramenghi U.

2023/4 — pag. 249-254 — DOI

This brief report presents a practical approach to the diagnosis of the main coagulopathies in children with haemorrhagic manifestations. It discusses the clinical-anamnestic elements that should suggest further laboratory investigations. Then, after...

Quando l’anemia viene da un’infezione da parvovirus

Tolomelli E, Legnani E, Grasso A

2023/3 — pag. 53-53 — DOI

The author describes the case of a 2-year-old boy presenting with aplastic anaemia due to documented parvovirus infection of the bone marrow without a specific seroconversion....

Un mal di schiena fastidioso

Trombetta A, Corona F, Cozzi C, Barbi E.

2022/8 — pag. 519-520 — DOI

A 7-year-old boy was admitted to the Emergency Unit for a one-month history of low back pain, which got worse and resulted in a refusal to walk. On physical examination, the patient refused to stand, and palpation of the spinous processes of the lumb...

Quando la linfoistiocitosi emofagocitica è secondaria

Ventresca S, Fabbri E, Bracaglia C, Gasperini P, Filippini B, Libertucci F, Bigucci B, Pericoli R, Vergine G.

2022/2 — pag. 97-102 — DOI

The paper describes the case of a 1-year-old Caucasian boy with a 1-month history of fever and splenomegaly. Laboratory findings showed pancytopenia, hypertriglyceridemia and hyperferritinemia. Secondary haemophagocytic lymphohistiocytosis was suspec...

La sindrome di Chediak-Higashi a esordio tardivo

Ciancia S, Dalla Porta MF, Cingolani GM, Cellini M, Soresina A, Badolato R, Mariotti I, Cano Garcinuno MdC, Iughetti L

2021/4 — pag. 118-123 — DOI

Chediak-Higashi syndrome (CHS) is a rare autosomal recessive disorder caused by mutations in the CHS1/LYST gene, encoding for LYST protein, involved in lysosomal trafficking. It is characterized by recurrent bacterial infections, oculocutaneous albin...

Un’anemia emolitica da sferocitosi ereditaria

Ursi D, Valentino MS

2021/3 — pag. 193-195 — DOI

A case of haemolytic anaemia due to spherocytosis in a 3-month-old infant is reported. It is important to remember that post-transfusion blood tests are not reliable and must be repeated 3 months after the transfusion. The erythrocyte osmotic resista...

Picacismo e anemia

R. Conti, E. Da Dalt, M. Miani

2020/9 — pag. 599 — DOI

Sindromi emorragiche e lupus anticoagulante positivo

L. Facchini, C. Radice, L. Biserna, G. Poletti, F. Marchetti

2020/2 — pag. 97-100

The paper reports the cases of two children who presented with a coagulation alteration with a clinically evident haemorrhagic diathesis. In one case the child presented with cutaneous purpura, in the other case with bleeding of the upper digestive...

Zoppia, citopenia e VES: pensa anche al neuroblastoma

S. Andrade

2019/10 — pag. 250-250

Un’emolisi ben mascherata

G. Del Borrello

2018/6

Chronic haemolytic anaemia is a pathophysiological process that can be the expression of many possible etiologies (e.g. a congenital defect of a membrane protein, immune-mediated destruction, enzymopathies, altered erythrocyte development). The paper...

Febbre persistente, dolore toracico e arterite di Takayasu

B. Filippini, B. Bigucci, F. Mascella, M. Gattorno, G. Vergine

2018/5

Takayasu’s arteritis (TA) is an extremely rare vasculitis that presents in paediatric age that typically affects adolescents. Clinical manifestations of TA are polymorph and in the fists stage of the disease systemic aspecific symptoms such as fever,...

Una reazione periostale... niente ben

C. Di Chiara, P. Moras, F. Maschio, M. Minute

2018/5

La leucemia ridotta all’osso: fatti e misfatti

A.G. Grasso, C. Radice, F. Corrias, F. Verzegnassi, F. Marchetti

2017/7 — pag. 428-434

Acute Lymphoblastic Leukaemia (ALL) is the most common cancer disease in paediatric age. Even though in the last decade there has been a steady improve of the chances of survival from this disease, it is relatively uncommon in the life of a general...

Leucemia linfoblastica acuta del bambino: al bivio tra successi e interrogativi

A. Biondi

2017/7 — pag. 415

Ipereosinofilia severa: un caso da non dimenticare

E. Santi

2017/6

Mi fa male la schiena

S. Amoroso

2017/5

Brucellosi: un raro caso di recidiva

M.C. Castiglione

2017/1

Due bambini senza ferro

C. Landini, A. Campanile, R. Francavilla, P. Alvisi

2016/10 — pag. 660

Piastrinopenia autoimmune

M. Saruggia, B. Longhi, M. Colombo

2016/5 — pag. 319-321

Anemia ferrocarenziale

2015/9 — pag. 589-590

Anemia sideropenica nel III millennio“Nuovi” parametri di monitoraggio della risposta terapeutica

E. Parodi, M.L. Aurucci, B. Stella, G. Russo, U. Ramenghi

2015/8 — pag. 515-519

Iron deficiency and iron deficiency anaemia (IDA) secondary to inadequate dietary iron intake are still in the third millennium the most common nutritional disorder and the most common haematological diseases of infancy and childhood. The article d...

Cosa deve sapere il pediatra della linfoistiocitosi emofagocitica attraverso i casi degli specializzandi

S. Lega, F. Dell’Acqua, M. Minute, F. Vendemini, C. Cattelani

2015/7 — pag. 431-441

Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening syndrome caused by severe hypercytokinemia due to a highly stimulated but ineffective immune response. HLH is not a disease by its own but is rather a common final consequen...

Una febbre alta e persistente con epatosplenomegalia e citopenia

L. de Seta, M.S. Sabatino, F. de Seta, P. Siani

2015/7 — pag. 431-441

The case described is that of an 11-year-old child presenting with high fever, pharyngotonsillar exudate, submandibular strangles and hepatosplenomegaly. The elevated number of VCA IgM antibodies led to a diagnosis of infectious mononucleosis. The ...

Dolore alle ossa, febbricola e aumento degli indici di flogosi: pensare anche alla osteomielite cronica multifocale ricorrente

M. Cappella, S. dal Bo, L. Berretti, F. Ravaioli, R. Burnelli, F. Marchetti

2014/7

The paper reports the case of a 7-year-old child who pre-sented with recurrent multifocal bone pain associated with low fever, elevation of flogosis indexes and negative standard radiological exams. The spectrum of differential diagnosis was wide. Th...

Piastrine che scendono, piastrine che salgono: quando preoccuparsi?

E. Parodi, G. Ansaldi, C. Botto, M. Davitto, A. Mondino, C. Olivieri, U. Ramenghi

2013/10 — pag. 629-634

Thrombocytopenia and thrombocytosis are defined by a decreased or an elevated platelet count, respectively. Changes in the platelet number are frequently observed during childhood. This article aims at quickly examining the main causes of thrombocy...

La nuova diagnostica delle anemie microcitiche

A. Iolascon, A. Gambale, C. Tortora, M. Bruno, L. De Falco

2013/9 — pag. 563-569

Microcytic anaemia is the most common form of anaemia, characterized by reduced MCV, often associated with hypochromia of red blood cells. Among the causes of microcytic anaemia, iron deficiency anaemia is the most common. The latest scientific dis...

Senza parole

L. Basile

2013/8 — pag. 483-485

Reticolociti: un parametro poco conosciuto e troppo poco utilizzato

U. Ramenghi, G. Ansaldi, M. Davitto, A. Mondino, C. Olivieri, R. Mazzone

2012/10 — pag. 649-651

The paper describes the usefulness of reticulocyte count in the diagnosis and management of anaemia. Reticulocytes are immature red cells that do not have the nucleus, but hold residual extranuclear RNA. In traditional morphologic examination, reti...

Leishmania: un parassita, molte infezioni

S. Virano, D. Le Serre, S. Garazzino, E. Silvestro, P.A. Tovo

2012/8

A 10-year-old child presented with persistent fever, relevant hepatosplenomegaly and pancytopenia. Abdominal US imaging, serology for most relevant pathogens and Leishmania, PCR for Parvovirus B19 and bone marrow sample were performed in order to...

Gestione del neonato con sospetta o certa sepsi batterica a esordio precoce

V. Murgia

2012/6 — pag. 399-400

Un caso di emofilia acquisita

A. De Cunto, P. Pasquinelli, C. Biasioli, V. Agostini, M. Pocecco

2011/6 — pag. 397-398

The case of a boy who presented with an isolated gross haematuria is reported. In the previous days he referred a muscular haematoma after a minimal trauma. Coagulation studies showed a prolonged activated partial thromboplastin time (90 sec), not co...

Un PTT lungo “per caso”

U. Ramenghi, G. Ansaldi, M. Davitto

2011/6 — pag. 379-383

The aim of this short report is to discuss the abnormality that is more frequently found in coagulation assays, i.e. prolonged aPTT. This is most frequently due to presence of low levels of lupus anticoagulants. This alteration is transient and d...

Un caso di emofilia acquisita

A. De Cunto, P. Pasquinelli, C. Biasioli, V. Agostini, M. Pocecco

2011/6

The case of a boy who presented with an isolated gross haematuria is reported. In the previous days he referred a muscular haematoma after a minimal trauma. Coagulation studies showed a prolonged activated partial thromboplastin time (90 sec), not co...

Contare i globuli bianchi e leggere una formula leucocitaria in ambulatorio: un po’ di storia della medicina ancora e sempre attuale

L. Reggiani

2010/9

Leukocyte count may be the most immediately available and at the same time most significant lab indication to direct intervention in a feverish child, presenting with a marginally compromised general condition or in a patient with suspected appendici...

Una comunicazione difficile e una diagnosi scritta in cinese

C. Landini, E. Mazzoni, A. Lambertini

2010/3

L’esplorazione bioumorale del fegato: il bilancio epatico

G. Maggiore

2009/10 — pag. 649-653

Liver function tests are a simple way to explore liver function and are a helpful tool to the clinician to confirm the clinical suspect of liver disease. Practically, evaluation of liver function includes determination of total and conjugated bilir...

Leucemia linfoblastica acuta all\'esordio: quando nel dubbio è meglio fare...

G. Fusilli, V. Cecinati, G. Merico, M. Anna Piccione, G. Sarli, A. Granieri, G. Labalestra, F. Sarli, G. Russo, N. Santoro, D. De Mattia

2009/9

Leucemia linfoblastica acuta all’esordio: quando nel dubbio è meglio fare…

G. Fusilli, V. Cecinati, G. Merico, M.A. Piccione, G. Sarli, A. Granieri, G. Labalestra, F. Sarli, G. Russo, N. Santoro, D. De Mattia

2009/9 — pag. 597-598

Acute lymphoblastic leukemia is the most common malignancy diagnosed in children. We report the case of a female patient presenting with asthenia and limb pain when admitted to our Operative Unit of Pediatrics. Laboratory studies showed high leve...

La splenomegalia

M. Rabusin, F. Patarino

2007/8 — pag. 493-499

The spleen in infants and children is involved in a wide variety of pathological conditions. Splenic disorders may be isolated like splenic cysts or, more frequently, due to multiorgan or systemic disease including hepatic diseases, malignancy, hemo...

Un caso di eritrofagocitosi secondaria a leishmaniosi nell’entroterra friulano

F. Minen, C. Oretti, F. Marchetti, G. Zanazzo, M. Maschio, D. Lizzi, A Ventura

2007/5 — pag. 325-327

The present report describes the case of a 2-year-old girl that lives in Northern Italy suffering from a one month lasting fever, pallor and hepatosplenomegaly. Serum testing showed pancytopenia, high levels of immunoglobulins, hypertriglyceridemia a...

Un caso di zoppia

C. Galletto, N. Bertorello, E. Barisone, R. Mazzone, A. Andreacchio

2007/1 — pag. 51-53

In childhood and adolescence articular pains are frequent and in most of the cases they disappear rapidly and spontaneously. In a few patients the cause of the symptoms is an organic and/or a systemic pathology that require accurate examination a...

Anemie facili e difficili

U. Ramenghi

2007/1 — pag. 27-31

Most forms of anemias in childhood are easy to diagnose. A decreased mean corpuscolar volume (MCV) is due to reduced hemoglobin synthesis and suggests iron deficiency or thalassemia. Anemia with a normal MCV is mainly due to hemolysis or hemorrhage...

La fibrosi retroperitoneale idiopaticaDescrizione di due casi

Z. Cannioto, A. Lorusso, E. Barbi

2006/3

Dalla clinica all'esame strumentale: un ragazzo con sepsi e dolore alla gamba

Z. Cannioto, S. Storelli, F. Zennaro, J. Schleef, F. Marchetti

2006/2

Gialla di NataleMeglio con meno: ovvero contare i linfocitiAncora Paesi poveri Ancora su HIVMalattia di Fabry. Dall’adulto al giovane adulto, all’adolescente Alle braccia del pediatraTempi di terapie biologiche (e costose): due studi e 728 casi in una pubblicazioneTerapia biologica: anche nell’obesitàPrognosi del neuroblastoma (e invito a un pensiero su quanto cambia, ogni giorno, la medicina)Stipsi funzionale: prima si cura, meglio è

2005/10 — pag. 639-640

Manifestazioni ematologiche nelle malattie mitocondriali con mutazione dell’mt-DNA

R. Cerchio, F. Timeus, P. Saracco, et al.

2005/1 — pag. 57-58

We report a 10-month-old girl who, at the age of 4 months, was admitted for increasing pallor. Severe normocytic anaemia, neutropenia and thrombocytopenia and typical diffuse vacuolization of marrow haemopoietic precursors were present. She also ...

Sedazioni Profonde e ripetute in emato-oncologia:vissuto dei bambini affetti da leucemia e delle loro famiglie

L. Bana, I. Bruno, T. Geraraduzzi, E. Biasotto, I. Giuseppin, I. Berti, G. Zanazzo, M. Rabusin, R. Vecchi, E. Barbi, A. Sarti, P. Tamaro, A. Ventura.

2004/11

Sedazioni profonde ripetute in Emato-oncologia: vissuto dei bambini affetti da leucemia e delle loro famiglie

2004/11 — pag. 723-725

Painful procedures are a major source of distress for children with leukaemia and for their parents. Procedural sedation, and possibly deep sedation, is recommended for these patients. The aim of this study was to evaluate the attitudes of patient...

La paura e il dolore inevitabili

E. Barbi

2004/11 — pag. 675-676

Piastrinopenia isolata x-linked da mutazione missense del gene WASP: descrizione di un caso

C Locatelli, C Malaventura, R Ciambra, M Pocecco, L. D Notarangelo, L. D Notarangelo

2004/7

Piastrinopenia isolata X-linked da mutazione del gene WASP

2004/7 — pag. 450-450

Wiskott-Aldrich (WAS) and X-linked thrombocytopenia (XLT) are two disorders caused by different mutations of the gene WASP. WAS is characterized by recurrent infections, eczema, thrombocytopenia with low mean platet volume (MPV) and increased sus...

Precisazioni sull’emocromoFluoroprofilassiAncora sul costo dei latti!

2004/7 — pag. 423

Una bambina con febbre e dolore alle ossa

S. Bassanese, T. Gerarduzzi, F. Marchetti

2004/4

Leggere l’emocromo

I. Bruno

2004/2 — pag. 113-115

Rischio di progressione nei bambini sieropositivi per HIV trattati o meno con AZT.

T. Gerarduzzi

2003/9

Domande e risposte

2003/5 — pag. 328-330

Laboratorio "fai da te" in un ospedale africano

A. Azzini, S. Facchini, F. Panizon

2003/2

Laboratorio “fai da te” in un ospedale africano

2003/2 — pag. 127-128

Report of a field experience in an african hospital, where feasibility and usefulness of very simple laboratory tests (ESR, CRP, Mantoux, Urinalysis by dipstix) were evaluated. All laboratory examinations proved to be feasible and useful for case-...

Due fratelli e un’anemia

C. Rossetti, V. Mattei, L. Sebastiani

2002/6 — pag. 389-390

Sindromi autistiche e patologia gastrointestinale

2002/6 — pag. 391-392

We studied 55 children suffering from cryptogenetic autism. In 44/55 cases, recurrent constipation or diarrhoea were present. In 46/55 cases, the CD4/CD8 ratio was ...

Le microcitosi nel bambino: classificazione e approccio diagnostico

A. Sciotto, V. Furia, S.E. Munda

2001/2 — pag. 87-93

The Authors provide an overview of microcytic anemias. Causes of microcytic anemia include a wide variety of diseases, the most common being iron-deficiency, impaired haemoglobin synthesis, sideroblastic anemias and anemias due to chronic disease. ...

L'anemia ipocromica

G. Leo

1999/10

Febbri ricorrenti con alti indici di flogosi

A. Tommasini, L. Lepore

1999/8 — pag. 506-510

Una splenomegalia febbrile con neutropenia

C. Malorgio

1998/9

Una splenomegalia febbrile con neutropenia

P. Tamaro, C. Malorgio

1998/9 — pag. 581

Eritroblastopenia transitoria del bambino

F. Massei, M. Nardi, C. Favre e coll.

1998/4 — pag. 247-250

The Authors describe the diagnostic, therapeutical and prognostic features of transient erythroblastopenia of childhood (TEC) and report 5 cases. This disorder usually occurs in children aged between 6 mounts and 5 years. The clinical picture is...

La febbre alta nel lattante e nel bambino sotto i tre anni

S. Russian, C.M. Salvatore

1997/3 — pag. 171-175

The Authors review the recommendations on the management of fever in infants and children below three years of age, and compare them with the current practice of primary care paediatricians. Primary care practictioners indeed appear more confide...